IP3 receptor 2 / ITPR2 antibody

Principal name

IP3 receptor 2 / ITPR2 antibody

Alternative names for IP3 receptor 2 / ITPR2 antibody

Type 2 InsP3 receptor, IP3R2, Inositol 1,4,5-trisphosphate receptor type 2, Type 2 inositol 1,4,5-trisphosphate receptor

SwissProt ID

P29995 (Rat), Q14571 (Human), Q8WN96 (Bovin), Q9Z329 (Mouse)

Gene ID

3709 (ITPR2), 81678 (Itpr2), 16439

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bt (Bat), Bov (Bovine), Can (Canine), Chk (Chicken), Eq (Equine), Mky (Monkey), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Tr (Turkey), Bear

Available hosts

Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of IP3 receptor 2 / ITPR2 antibody

Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular Ca2+ release channels located on the endoplasmic reticulum (ER) and mediate Ca2+ mobilization from the ER to the cytoplasm in response to the binding of the second messenger, inositol 1,4,5-trisphosphate (IP3). IP3-induced Ca2+ release is triggered by various exterl stimuli, and most non-excitable cells use this mechanism as the primary Ca2+ sigling pathway. IP3Rs are therefore thought to have important physiological roles in various cell types and tissues. Three subtypes of IP3Rs, derived from three distinct genes, have been identified in mammals. All three receptors have six transmembrane domains and a pore domain between TM5 and TM6. The N-terminus as well as the C-terminus are cytoplasmic. Each IP3R consists of an N-termil ligand binding domain (LBD) and a C-termil domain which is linked by a long regulatory domain. The C-terminus is constitutively active, suggesting that the regulatory domain is required to maintain the suppression of channel activity. Type 2 IP3R (IP3R2) is expressed in various tissues and cell lines. IP3R2 mR is localized in the intralobular duct cells of the submandibular gland, the uriry tubule cells of the kidney, the epithelial cells of epididymal ducts and the follicular granulosa cells of the ovary. IP3R2 is active during osteoclast differentiation, and its absence causes a partial defect in osteoclastic differentiation.

General readings

Mesonero J.E. et al.. Differential expression of inositol 1,4,5-trisphosphate receptor types 1, 2, and 3 in rat myometrium and endometrium during gestation. Biol Reprod. 2000 Aug;63(2):532-7.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IP3 receptor 2 / ITPR2 antibody

  Rabbit Polyclonal Anti-IP3 Receptor-2  
Western blot analysis of rat brain membrane (lanes 1 and 3) and rat basophilic leukemia (RBL) cell line lysate (lanes 2 and 4): 1-2. Anti-IP3 Receptor-2 antibody , (1:200). 3-4. Anti-IP3 Receptor-2 antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €585.00
  OriGene Technologies, Inc.

IP3 receptor 2 / ITPR2 antibody

  Rabbit Polyclonal Anti-ITPR2 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using (ITPR2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu E, P
0.1 ml / €335.00
  OriGene Technologies, Inc.

IP3 receptor 2 / ITPR2 antibody

IP3 receptor 2 / ITPR2 Rabbit Serum Rt C, E, WB
0.2 ml / €430.00
  OriGene Technologies GmbH

IP3 receptor 2 / ITPR2 (1152-1164) antibody

Human Kidney (formalin-fixed, paraffin-embedded) stained with ITPR2 antibody AP22536PU-N at 3.75 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Hu, Mky E, P
50 µg / €425.00
  OriGene Technologies GmbH

4 Item(s)

per page
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