IP3 receptor 2 / ITPR2 antibody

Principal name

IP3 receptor 2 / ITPR2 antibody

Alternative names for IP3 receptor 2 / ITPR2 antibody

Type 2 InsP3 receptor, IP3R2, Inositol 1,4,5-trisphosphate receptor type 2, Type 2 inositol 1,4,5-trisphosphate receptor

SwissProt ID

P29995 (Rat), Q14571 (Human), Q8WN96 (Bovin), Q9Z329 (Mouse)

Gene ID

3709 (ITPR2), 81678 (Itpr2)

Available reactivities

Ms (Mouse), Rt (Rat), Hu (Human), Can (Canine), Hst (Hamster), Mky (Monkey), Bov (Bovine)

Available hosts

Rabbit, Goat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP)

Background of IP3 receptor 2 / ITPR2 antibody

Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neuro-transmitters. Upon binding to the IP3 receptor (IP3R), IP3 triggers the release of intracellular, luminal calcium to the cytosol. Functional IP3R is a homo- or heterotetramer of ~240 kDa glycoprotein subunits, that is structurally reminiscent of members of the voltage-gated ion channel superfamily. IP3R protein is structurally and functionally related to one other important intracellular calcium-release channel, the ryanodine receptor. The similarity between the two receptors continues at the physiological level owing to a physical association each receptor can have with the immunophilin protein, FKBP12. Cytosolic calcium levels appear to be regulated by a feedback loop that starts with calcium activation of protein kinase C (PKC) and calcineurin, a protein phosphatase. Phosphorylation of the IP3R by PKC causes an increase in IP3-mediated calcium release. Concomitantly, the phosphatase activity of calcineurin is stimulated upon its association with the FKBP12-IP3R complex. Calcium release is reduced when the PKC target site on the IP3R is dephosphorylated by calcineurin resulting in calcium oscillations. Mammalian IP3R subunits are the product of three distinct genes that are widely expressed and differentially regulated. IP3R type I (IP3R-I) has been detected in heart, liver, kidney, ovary, and Purkinje neurons of the cerebellum. IP3R-II is found predominantly in the brain. IP3R-III is known to be expressed in pancreatic islets, kidney, and the gastrointestinal tract.

General readings

Futatsugi A, Nakamura T, Yamada MK, Ebisui E, Nakamura K, Uchida K, Kitaguchi T, Takahashi-Iwanaga H, Noda T, Aruga J, Mikoshiba K. IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science. 2005 Sep 30;309(5744):2232-4. PMID: 16195467

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IP3 receptor 2 / ITPR2 antibody

Western blot analysis of rat brain membrane (lanes 1 and 3) and rat basophilic leukemia (RBL) cell line lysate (lanes 2 and 4): 1-2. Anti-IP3 Receptor-2 antibody , (1:200). 3-4. Anti-IP3 Receptor-2 antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

IP3 receptor 2 / ITPR2 (1152-1164) antibody

Human Kidney (formalin-fixed, paraffin-embedded) stained with ITPR2 antibody AP22536PU-N at 3.75 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bear, Bov, Bt, Can, Chk, Eq, Hu, Mky, Ms, Op, Por, Prim, Rb, Tr E, P
50 µg / €470.00
  Acris Antibodies GmbH

IP3 receptor 2 / ITPR2 antibody

IP3 receptor 2 / ITPR2 Rabbit Serum Rt C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

IP3 receptor 2 / ITPR2 antibody

IP3 receptor 2 / ITPR2 Rabbit Hu, Ms, Rt E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

IP3 receptor 2 / ITPR2 antibody

IP3 receptor 2 / ITPR2 Goat Hu, Ms, Rt E
0.1 mg / €390.00
  Abnova Taiwan Corp.

IP3 receptor 2 / ITPR2 antibody

Western Blot: ITPR2 Antibody: 2 sec exposure using NB100-2466 on 80 ug total cell lysates listed above.  Primary antibody applied at 1:500 overnight at 4degC, secondary donkey anti-goat applied for 2 hours at room temperature at 1:5000.  (Data provided by Karen McColl at Case Western Reserve University) Goat IgG Aff - Purified Hu, Rt E, WB
0.1 mg / €320.00
  Novus Biologicals Inc.

IP3 receptor 2 / ITPR2 antibody

IP3 receptor 2 / ITPR2 Rabbit Purified Hu, Ms, Rt WB
0.1 ml / €320.00
  Novus Biologicals Inc.

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