IRAK1 antibody

Principal name

IRAK1 antibody

Alternative names for IRAK1 antibody

IRAK-1, IRAK, Interleukin-1 receptor-associated kinase 1

SwissProt ID

P51617 (Human), Q2LGB3 (Bovin), Q62406 (Mouse)

Gene ID

3654 (IRAK1), 16179 (Irak1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of IRAK1 antibody

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3 (By similarity).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IRAK1 (C-term) antibody

Western blot analysis of IRAK in THP-1 (THP) and HeLa (HL) whole cell lysates with IRAK antibody at 1:2000 Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRAK1 antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 3F7 Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

IRAK1 antibody

Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 3A9 Hu E, ICC/IF, IP, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

IRAK1 antibody

Immunoperoxidase of monoclonal antibody to IRAK1 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml] Mouse IgG2a 3F7 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

IRAK1 antibody

Immunoperoxidase of monoclonal antibody to IRAK1 on formalin-fixed paraffin-embedded human lung. [antibody concentration 3 ug/ml] Mouse IgG1 3A9 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

IRAK1 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue using IRAK1 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

IRAK1 (618-712) antibody

Western blot analysis of IRAK in HeLa lysates with IRAK antibody at (A) 1 and (B) 2 ug/mL. Mouse IgG 1F12C1 Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRAK1 (618-712) antibody

Western blot analysis of IRAK in mouse liver lysate with IRAK antibody at (A) 1 and (B) 2 ug/mL. Mouse IgG 8F1A7 Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRAK1 antibody

Western Blot: IRAK Antibody [TA336450] - Analysis of IRAK-1 in 1) human HeLa and 2) mouse NIH3T3 lysate using IRAK-1 antibody at 1 ug/ml. Rabbit Purified Hu, Ms, Rt IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRAK1 antibody

Western blot (WB) analysis of IRAK1 antibody (Cat.-No.: AP06527PU-N) in extracts from HeLa cells. Rabbit Aff - Purified Hu, Ms ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

IRAK1 antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Brain, cortex. Rabbit Purified Hu, Ms, Rt E, IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IRAK1 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

IRAK1 antibody

Immunohistochemistry analyzes of IRAK1 antibody (Cat.-No.: AP20311PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

IRAK1 (C-term) antibody

Human Placenta (formalin-fixed, paraffin-embedded) stained with IRAK1 antibody AP22789PU-N followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IRAK1 Control Peptide

IRAK1
50 µg / €160.00
  Acris Antibodies GmbH

IRAK1 pSer376 antibody

Immunohistochemical analysis of paraffin-embedded human brain tissue using IRAK1 (Phospho-Ser376) antibody AP55759PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu P
0.1 ml / €340.00
  Acris Antibodies GmbH

IRAK1 pSer376 antibody

Immunohistochemical analysis of paraffin-embedded human brain tissue using IRAK1 (Phospho-Ser376) antibody AP55759PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu P
50 µl / €270.00
  Acris Antibodies GmbH

IRAK1 antibody

Immunocytochemical staining of HeLa cells with Rabbit anti Human IRAK-1 (SP1187P) Rabbit Purified Hu ICC/IF, IP, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

IRAK1 antibody

Western Blot analysis of IRAK1 expression in transfected 293T cell line (H00003654-T01) by IRAK1 MaxPab polyclonal antibody.

Lane 1: IRAK1 transfected lysate(69.63 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

IRAK1 antibody

Western Blot analysis of IRAK1 expression in transfected 293T cell line (H00003654-T01) by IRAK1 MaxPab polyclonal antibody.

Lane 1: IRAK1 transfected lysate(69.63 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

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