IRAK3 antibody

Principal name

IRAK3 antibody

Alternative names for IRAK3 antibody

IRAK-3, IRAK-M, Interleukin-1 receptor-associated kinase 3, IL-1 receptor-associated kinase M

SwissProt ID

Q8K4B2 (Mouse), Q9Y616 (Human)

Gene ID

11213 (IRAK3), 73914 (Irak3)

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of IRAK3 antibody

Interleukin-1 receptor (IL1R)-associated kinases (IRAKs) are important mediators in the signal transduction of Toll-like receptor (TLR) and IL1R family members, collectively referred to as TIRs. Binding of IL-1 to its cognate receptor results in the activation of the NFκB signaling pathway. A 100 kDa IL-1- dependent kinase termed IRAK-1 (for IL-1 receptor- associated kinase 1) coimmunoprecipitates with activated IL-1RI and is implicated as an upstream mediator of NFκB activation. A related Drosophila protein, Pelle, is a known upstream activator of Dorsal, the Drosophila homolog of NFκB. IRAK-2 is a proximal mediator of IL1, a component of the IL1R signaling complex, and is required for IL1R-induced NFκB activation. IRAK-4, like IRAK-1 and Pelle, has auto- and cross-phosphorylation kinase activity. IRAK-4 is strongly expressed in kidney and is also found in lung, testis, small intestine, breast, liver, and placenta. In contrast to the other IRAKs that are expressed in most cell types, IRAK-M is restricted to monocytic cells. IRAK-M mRNA transcripts are found predominantly in PBL and the monocytic cell lines U937 and THP-1.

General readings

del (2005) J. Immunol. 174 (5), 3032-3040

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IRAK3 antibody

  Goat Polyclonal Antibody against IRAK3  
TA303364 (0.05µg/ml) staining of Rat Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detceted with chemiluminescence. Goat Aff - Purified Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRAK3 antibody

  Rabbit Polyclonal IRAK-M Antibody  
Western blot analysis of IRAK-M in mouse spleen (M) and rat liver (R) tissue lysates with IRAK-M antibody at 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRAK3 antibody

  Rabbit Polyclonal antibody to IRAK3 (interleukin-1 receptor-associated kinase 3)  
Sample (50 ug of whole cell lysate). A: mouse liver. 7.5% SDS PAGE. TA308809 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IRAK3 antibody

  Rabbit anti-IRAK3 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using IRAK3 antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRAK3 antibody

  Rabbit Polyclonal Anti-IRAK3 Antibody  
WB Suggested Anti-IRAK3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

IRAK3 antibody

  Rabbit Polyclonal Anti-IRAK3 Antibody  
Western blot analysis on K562 cell lysate using IRAK3 Antibody Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRAK3 antibody

Immunohistochemistry (IHC) analyzes of IRAK-M antibody (Cat.-No.: AP01287PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

IRAK3 antibody

Tonsil: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IRAK3 (N-term) antibody

Western blot analysis of anti-IRAK3 Pab in HL-60 cell lysate. IRAK3 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

IRAK3 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using IRAK3 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, P, WB
50 µg / €230.00
  Assay Biotech

IRAK3 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using IRAK3 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

IRAK3 - human gene knockout kit via CRISPR

IRAK3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

IRAK3 - human gene knockout kit via CRISPR

IRAK3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Irak3 - mouse gene knockout kit via CRISPR

Irak3 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Irak3 - mouse gene knockout kit via CRISPR

Irak3 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Irak3 - mouse gene knockout kit via CRISPR

Irak3 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Irak3 - mouse gene knockout kit via CRISPR

Irak3 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

IRAK3 (transcript variant 1)

  Recombinant protein of human interleukin-1 receptor-associated kinase 3 (IRAK3), transcript variant 1  
IRAK3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

IRAK3 overexpression lysate

IRAK3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

IRAK3 overexpression lysate

IRAK3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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