IRAK4 antibody

Principal name

IRAK4 antibody

Alternative names for IRAK4 antibody

IRAK-4, NY-REN-64, Interleukin-1 receptor-associated kinase-like

SwissProt ID

Q1RMT8 (Bovin), Q8R4K2 (Mouse), Q9NWZ3 (Human)

Gene ID

51135 (IRAK4), 266632 (Irak4)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Bt (Bat), Can (Canine), Eq (Equine), Hst (Hamster), Mky (Monkey), Por (Porcine), Prim (Primate), Rb (Rabbit), Sh (Sheep), L (Lizard), Bear, Rt (Rat)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Dot blot (Dot), Immunoprecipitation (IP), Flow Cytometry (F), ELISA (detection) (E(detection))

Background of IRAK4 antibody

The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. IL-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members. The cytoplasmic domains of TIR proteins interact with the adapter protein, MyD88. MyD88 then recruits IRAKs (IRAK-1, -2, and M), which in turn interact with other adapter molecules, such as TRAF6 to activate NF-kB and MAPK pathways. Recently, a new member of this family, IRAK-4 has been identified. IRAK-4 may act as an upstream activator of IRAK-1. IRAK-4 is important for LPS activation of TLRS. Mice lacking IRAK-4 are resistant to lethal doses of LPS and are also severely impaired in their responses to viral and bacterial challenges.

General readings

Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
McDonald, D.R., et al. J. Allergy Clin. Immunol. 126(2):332-337(2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
Wang, Z., et al. Structure 14(12):1835-1844(2006)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IRAK4 antibody

Immunohistochemical analysis of paraffin-embedded human kidney cancer tissues using IRAK4 mouse mAb with DAB staining. Mouse IgG1 2H9 Ascites Hu, Mky, Ms E, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

IRAK4 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 6F8 Alexa Fluor 488 Can, Hu F, ICC/IF
50 µg / €390.00
  Dendritics SAS

IRAK4 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 6F8 Alexa Fluor 488 Can, Hu F, ICC/IF
0.1 mg / €520.00
  Dendritics SAS

IRAK4 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 6F8 Alexa Fluor 546 Can, Hu F, ICC/IF
50 µg / €390.00
  Dendritics SAS

IRAK4 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 6F8 Alexa Fluor 546 Can, Hu F, ICC/IF
0.1 mg / €520.00
  Dendritics SAS

IRAK4 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 6F8 Biotin Can, Hu
50 µg / €360.00
  Dendritics SAS

IRAK4 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 6F8 Biotin Can, Hu
0.1 mg / €480.00
  Dendritics SAS

IRAK4 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 6F8 Purified Can, Hu C, F, ICC/IF, P, WB
50 µg / €330.00
  Dendritics SAS

IRAK4 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 6F8 Purified Can, Hu C, F, ICC/IF, P, WB
0.1 mg / €440.00
  Dendritics SAS

IRAK4 (N-term) antibody

  Goat Polyclonal Antibody against IRAK4 (N Terminus)  
TA302664 (1µg/ml) staining of Hela lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRAK4 antibody

  Rabbit Polyclonal IRAK-4 Antibody  
Western blot analysis of IRAK-4 in HeLa cell lysate with IRAK-4 antibody at 1 (lane 1), 2 (lane 2), and 4 (lane 3) ug/mL, respectively. Rabbit IgG Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRAK4 antibody

Western blot analysis of IRAK-4 expression with HeLa cell lysate. Rabbit Aff - Purified Hu WB
0.1 mg / €390.00
  Acris Antibodies GmbH

IRAK4 antibody

Spleen: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IRAK4 (38-54, 120-136) antibody

Kidney: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IRAK4 (2-13) antibody

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Hst, Hu, L, Mky, Ms, Por, Prim, Rb, Sh E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IRAK4 (N-term) antibody

Western blot analysis of IRAK4 Antibody (N-term) Cat.-No AP52231PU-N in NCI-H460 cell line lysates (35ug/lane). This demonstrates the IRAK4 antibody detected the IRAK4 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

IRAK4 antibody

IRAK4 Mouse IgG1 7D8 Alexa Fluor 488 Hu ICC/IF
50 µg / €390.00
  Dendritics SAS

IRAK4 antibody

IRAK4 Mouse IgG1 7D8 Alexa Fluor 488 Hu ICC/IF
0.1 mg / €520.00
  Dendritics SAS

IRAK4 antibody

IRAK4 Mouse IgG1 7D8 Alexa Fluor 546 Hu ICC/IF
50 µg / €390.00
  Dendritics SAS

IRAK4 antibody

IRAK4 Mouse IgG1 7D8 Alexa Fluor 546 Hu ICC/IF
0.1 mg / €520.00
  Dendritics SAS

Items 1 to 20 of 36 total

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