IRAK4 antibody

Principal name

IRAK4 antibody

Alternative names for IRAK4 antibody

IRAK-4, NY-REN-64, Interleukin-1 receptor-associated kinase-like

SwissProt ID

Q1RMT8 (Bovin), Q8R4K2 (Mouse), Q9NWZ3 (Human)

Gene ID

51135 (IRAK4), 3511355 (Q4WVK2)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Mky (Monkey), Can (Canine), Rt (Rat)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Dot blot (Dot), Immunoprecipitation (IP), Flow Cytometry (F), ELISA (detection) (E(detection))

Background of IRAK4 antibody

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.

General readings

Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
McDonald, D.R., et al. J. Allergy Clin. Immunol. 126(2):332-337(2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
Wang, Z., et al. Structure 14(12):1835-1844(2006)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IRAK4 antibody

Immunohistochemical analysis of paraffin-embedded human kidney cancer tissues using IRAK4 mouse mAb with DAB staining. Mouse IgG1 2H9 Ascites Hu, Mky, Ms E, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

IRAK4 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 6F8 Alexa Fluor 488 Can, Hu F, ICC/IF
50 µg / €390.00
  Dendritics SAS

IRAK4 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 6F8 Alexa Fluor 488 Can, Hu F, ICC/IF
0.1 mg / €520.00
  Dendritics SAS

IRAK4 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 6F8 Alexa Fluor 546 Can, Hu F, ICC/IF
50 µg / €390.00
  Dendritics SAS

IRAK4 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 6F8 Alexa Fluor 546 Can, Hu F, ICC/IF
0.1 mg / €520.00
  Dendritics SAS

IRAK4 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 6F8 Biotin Can, Hu
50 µg / €360.00
  Dendritics SAS

IRAK4 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 6F8 Biotin Can, Hu
0.1 mg / €480.00
  Dendritics SAS

IRAK4 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 6F8 Purified Can, Hu C, F, ICC/IF, P, WB
50 µg / €330.00
  Dendritics SAS

IRAK4 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 6F8 Purified Can, Hu C, F, ICC/IF, P, WB
0.1 mg / €440.00
  Dendritics SAS

IRAK4 (N-term) antibody

TA302664 (1µg/ml) staining of Hela lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu, Ms E, WB
20 µg / €200.00
  Acris Antibodies GmbH

IRAK4 (N-term) antibody

TA302664 (1µg/ml) staining of Hela lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRAK4 antibody

Western blot analysis of IRAK-4 in HeLa cell lysate with IRAK-4 antibody at 1 (lane 1), 2 (lane 2), and 4 (lane 3) ug/mL, respectively. Rabbit IgG Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRAK4 antibody

Western blot analysis of IRAK-4 expression with HeLa cell lysate. Rabbit Aff - Purified Hu WB
0.1 mg / €390.00
  Acris Antibodies GmbH

IRAK4 antibody

Spleen: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IRAK4 (38-54, 120-136) antibody

Kidney: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IRAK4 (2-13) antibody

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Hst, Hu, L, Mky, Ms, Por, Prim, Rb, Sh E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IRAK4 Control Peptide

IRAK4
50 µg / €160.00
  Acris Antibodies GmbH

IRAK4 (N-term) antibody

Western blot analysis of IRAK4 Antibody (N-term) Cat.-No AP52231PU-N in NCI-H460 cell line lysates (35ug/lane). This demonstrates the IRAK4 antibody detected the IRAK4 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

IRAK4 antibody

IRAK4 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

IRAK4 antibody

IRAK4 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

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