IREB2 antibody

Principal name

IREB2 antibody

Alternative names for IREB2 antibody

IRE-BP2, Iron regulatory protein 2, IRP2, Iron-responsive element-binding protein 2

SwissProt ID

P48200 (Human), Q62751 (Rat), Q811J3 (Mouse)

Gene ID

3658 (IREB2)

Available reactivities

Hu (Human), Ms (Mouse), Mky (Monkey), Rt (Rat), Can (Canine), Por (Porcine), African clawed frog, Prim (Primate), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Mouse, Goat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Flow Cytometry (F), Frozen Sections (C)

Background of IREB2 antibody

Iron regulatory protein 2 (IREB2 or IRP2) is a central regulator of cellular iron homeostasis due to its regulation of specific mRNAs encoding proteins of iron uptake and storage. In mammalian cells, regulation of the expression of proteins involved in iron metabolism is achieved through interactions of iron-sensing proteins known as iron regulatory proteins (IRPs), with transcripts that contain RNA stem-loop structures referred to as iron responsive elements (IREs). Two distinct but highly homologous proteins, IRP1 and IRP2, bind IREs with high affinity when cells are depleted of iron, inhibiting translation of some transcripts, such as ferritin, or turnover of others, such as the transferrin receptor (TFRC). IRPs sense cytosolic iron levels and modify expression of proteins involved in iron uptake, export and sequestration according to the needs of individual cells. Regulating the amount of iron sequestered by ferritin and taken up by transferrin receptor ensures that cells acquire sufficient iron for their needs, while preventing iron toxicity.

General readings

Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Hansen, H.M., et al. Hum. Mol. Genet. 19(18):3652-3661(2010)
Cho, M.H., et al. Nat. Genet. 42(3):200-202(2010)
Salahudeen, A.A., et al. Science 326(5953):722-726(2009)
DeMeo, D.L., et al. Am. J. Hum. Genet. 85(4):493-502(2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IREB2 antibody

TA305765 (0.3ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IREB2 antibody

Raw macrophages (mouse) were either left untreated (lane 1) or treated overnight with 100mM DFO (lane 2) or 100mM hemin (lane 3). Proteins extracts were subjected to western blotting using IRP2 or b-actin antibodies diluted 1:500 in TBS-Tween. Rabbit Purified Hu, Ms, Prim, Rt C
0.1 ml / €325.00
  OriGene Technologies, Inc.

IREB2 antibody

WB Suggested Anti-IREB2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Liver Rabbit IgG Purified Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

IREB2 (Center) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue reacted with IREB2 Antibody (Center) Cat.-No AP52232PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

IREB2 antibody

Western Blot analysis of IREB2 expression in transfected 293T cell line (H00003658-T01) by IREB2 MaxPab polyclonal antibody.

Lane 1: IREB2 transfected lysate(37.73 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

IREB2 antibody

Western Blot analysis of IREB2 expression in transfected 293T cell line (H00003658-T02) by IREB2 MaxPab polyclonal antibody.

Lane 1: IREB2 transfected lysate(37.84 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

IREB2 antibody

IREB2 Mouse IgG2a 1F3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

IREB2 antibody

Western blot analysis of Ireb2 in mouse liver lysate using Ireb2 polyclonal antibody ( Cat # PAB12137 ). Rabbit Hu, Ms, Rt WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

IREB2 antibody

Western blot analysis of IREB2 in mouse liver lysate using IREB2 polyclonal antibody ( Cat # PAB12533 ). Rabbit Ms WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

IREB2 antibody

Mouse Liver; Researcher: Dr. Hao Zhu, University of Kansas Medical Center. Application: Western blotting. Species+tissue/cell type: Mouse liver extract. How many ug'sof tissue/cell lysate run on the gel:1. 60 ug mouse liver extract2. 60 ug mouse liver extract3. 60 ug mouse liver extract. Primary antibody dilution: 1:500. Secondary antibody: Anti-rabbit HRP. Secondary antibody dilution: 1:3000; IREB2 antibody - middle region (ARP40509_P050) in Mouse Liver cells using Western Blot Rabbit Aff - Purified African clawed frog, Can, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

IREB2 antibody

Western blot: Detection of IRP2 in mouse liver lysate using NB100-1797. Rabbit Aff - Purified Hu, Ms ICC/IF, WB
0.1 ml / €380.00
  Novus Biologicals Inc.

IREB2 antibody

IREB2 Rabbit Biotin Ms WB
0.1 ml / €360.00
  Novus Biologicals Inc.

IREB2 antibody

IREB2 Rabbit DyLight488 Ms WB
0.1 ml / €390.00
  Novus Biologicals Inc.

IREB2 antibody

IREB2 Rabbit HRP Ms WB
0.1 ml / €390.00
  Novus Biologicals Inc.

IREB2 antibody

IREB2 Rabbit Hu, Ms ICC/IF, WB
25 µl / €170.00
  Novus Biologicals Inc.

IREB2 antibody

IREB2 Rabbit Biotin Ms WB
0.1 ml / €360.00
  Novus Biologicals Inc.

IREB2 antibody

IREB2 Rabbit DyLight488 Ms WB
0.1 ml / €390.00
  Novus Biologicals Inc.

IREB2 antibody

IREB2 Rabbit HRP Ms WB
0.1 ml / €390.00
  Novus Biologicals Inc.

IREB2 antibody

IREB2 Rabbit Hu, Mky, Ms, Rt ICC/IF, P, WB
25 µl / €200.00
  Novus Biologicals Inc.

IREB2 antibody

Immunohistochemistry-Paraffin: IRP2 Antibody [NBP1-51966] - staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Hu E, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

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