IRF3 antibody

Principal name

IRF3 antibody

Alternative names for IRF3 antibody

Interferon regulatory factor 3, IRF-3

SwissProt ID

P70671 (Mouse), Q14653 (Human), Q4JF28 (Bovin), Q764M6 (Pig), Q90643 (Chick)

Gene ID

3661 (IRF3), 54131 (Irf3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Frozen Sections (C)

Background of IRF3 antibody

Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection. IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, ISGF3?/p48, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-termil D-binding domains. IRF family members regulate transcription through interactions with proteins that share similar D-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E).IRF-3 can inhibit cell growth and plays a critical role in controlling the expression of genes in the inte immune response. In unstimulated cells, IRF-3 is present in the cytoplasm. Viral infection results in phosphorylation of IRF-3 and leads to its translocation to the nucleus where it activates promoters containing IRF-3-binding sites. Phosphorylation of IRF-3 occurs at a cluster of C-termil Ser and Thr residues (between 385 and 405), leading to its association with the p300/CBP coactivator protein that promotes D binding and transcriptiol activity. During infection, IRF-3 is likely activated through a pathway that includes activation of Toll-like receptors and a kise complex that includes IKKe and TBK1. IRF-3 is phosphorylated at Ser396 following viral infection, expression of viral nucleocapsid, and double-stranded R treatment. These events likely play a role in activation of IRF-3.

General readings

Pietila TE et al., J Immunol. (2007) 178(1):253-61.
DeFilippis VR et al., J Virol., (2006) 80(2):1032-7.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IRF3 antibody

Western blot analysis of extracts of brain cell lines, using IRF3 antibody. Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRF3 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of breast tissue using anti-IRF3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500465, Dilution 1:50) Mouse IgG2b OTI5D2 Purified Hu, Mky P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IRF3 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-IRF3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500476) Mouse IgG2a OTI4D4 Purified Hu F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

IRF3 antibody

Immunohistochemical staining of paraffin-embedded breast tissue within the normal limits using anti-IRF3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500520, Dilution 1:50) Mouse IgG2a OTI2G3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

IRF3 antibody

Immunohistochemistry-Paraffin: IRF3 Antibody (2G3) [NBP1-47812] - Immunohistochemical staining of paraffin-embedded endometrium tissue using anti-IRF3mouse monoclonal antibody. (Dilution 1:50) Mouse 2G3 Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €530.00
  Novus Biologicals Inc.

IRF3 (C-term) antibody

Western blot analysis of IRF3 in Ramos whole cell lysate with IRF3 antibody at (A) 1, (B) 2, and (C) 4 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRF3 antibody

Western blot analysis of IRF3 in U937 whole cell lysate with IRF3 antibody at (A) 1, (B) 2, and (C) 4 ug/mL. Rabbit IgG Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRF3 antibody

Western blot analysis of extracts from Jurkat cells and 293 cells, using IRF-3 (Ab-386) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IRF3 antibody

Western blot analysis of extracts from HeLa cells, using IRF3 (Ab-396) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IRF3 antibody

Western blot analysis of IRF3 expression in K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

IRF3 antibody

Hela cell extract was resolved by electrophoresis, transferred to nitrocellulose, and probed with anti-human IRF-3 antibody.  Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection system. Mouse IgG1 SL-12 Purified Hu IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRF3 antibody

Immunofluorescence of human HeLa cells stained with IRF-3 (1:500) with Texas-Red and Hoechst 33342 (Blue) for nucleus staining. Mouse IgG1 3F10 Purified Hu E, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

IRF3 (108-166) antibody

Immunofluorescence of human HeLa cells stained with IRF-3 (1:500) with Texas-Red and Hoechst 33342 (Blue) for nucleus staining. Mouse IgG1 3F10 Purified Hu E, ICC/IF, IP, WB
50 µl / €220.00
  Acris Antibodies GmbH

IRF3 antibody

Immunohistochemistry (IHC) analyzes of IRF-3 antibody (Cat.-No.: AP01444PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

IRF3 antibody

Immunohistochemistry (IHC) analyzes of IRF-3 antibody (Cat.-No.: AP06528PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

IRF3 (C-term) antibody

Prostate: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IRF3 antibody

Prostate: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IRF3 antibody

Liver: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Mky, Ms, Rt P, WB
50 µl / €470.00
  Acris Antibodies GmbH

IRF3 Control Peptide

IRF3
50 µg / €160.00
  Acris Antibodies GmbH

IRF3 Control Peptide

IRF3
50 µg / €160.00
  Acris Antibodies GmbH

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