IRF8 / ICSBP1 antibody

Principal name

IRF8 / ICSBP1 antibody

Alternative names for IRF8 / ICSBP1 antibody

Interferon regulatory factor 8, IRF-8, Interferon consensus sequence-binding protein

SwissProt ID

P23611 (Mouse), Q02556 (Human), Q90871 (Chick)

Gene ID

3394 (IRF8), 15900 (Irf8)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bt (Bat), Bov (Bovine), Can (Canine), Eq (Equine), Hst (Hamster), Mky (Monkey), Prim (Primate), Rb (Rabbit), Xen (Xenopus), Bear, Chk (Chicken), Ze (Zebrafish), African clawed frog

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of IRF8 / ICSBP1 antibody

Interferon regulatory factor 8 (IRF8, interferon consensus sequence-binding protein, ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved D-binding domain in the N-termil region and a divergent C-termil region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, mely IFN-. and IFN-.. IRF family proteins also control expression of IFN-. and IFN-.-regulated genes that are induced by viral infection. Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved D-binding domain in the N-termil region and a divergent C-termil region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, mely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications.

General readings

Weisz A, Marx P, Sharf R, Appella E, Driggers PH, Ozato K, Levi BZ.
Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.
J Biol Chem. 1992 Dec 15;267(35):25589-96.
PMID: 1460054

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IRF8 / ICSBP1 (C-term) antibody

  Goat Polyclonal Antibody against ICSBP1  
TA302820 staining (1µg/ml) of K562 lysate (RIPA buffer, 30µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRF8 / ICSBP1 antibody

  Rabbit Polyclonal IRF8 Antibody  
Western blot analysis of IRF8 in human thymus tissue lysate with IRF8 antibody at 1µg/ml in (A) the presence and (B) absence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRF8 / ICSBP1 antibody

  Rabbit Polyclonal Anti-IRF8 Antibody  
WB Suggested Anti-IRF8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

IRF8 / ICSBP1 antibody

  Rabbit Polyclonal Anti-IRF8 Antibody  
WB Suggested Anti-IRF8 Antibody Titration: 1.25ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRF8 / ICSBP1 antibody

  Rabbit Polyclonal Anti-IRF8 Antibody  
WB Suggested Anti-IRF8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:7812500; Positive Control: THP-1 cell lysate Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

IRF8 / ICSBP1 antibody

  Rabbit anti-IRF8 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using IRF8 antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRF8 / ICSBP1 (C-term) antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Small Intestine, Peyer's patch. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IRF8 / ICSBP1 (414-426) antibody

IRF8 / ICSBP1 Goat IgG Aff - Purified Elephant, Hu, Platypus E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

IRF8 / ICSBP1 (C-term) antibody

Western blot analysis of anti-IRF8 Antibody (C-term) (Cat.#AP12482PU-N) in HL60 cell line lysates (35ug/lane). IRF8 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

IRF8 / ICSBP1 antibody

Western blot analysis of anti-IRF8 Antibody (Center) (Cat.#AP12483PU-N) in Jurkat cell line lysates (35ug/lane). IRF8 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

IRF8 - human gene knockout kit via CRISPR

IRF8 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

IRF8 - human gene knockout kit via CRISPR

IRF8 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

IRF8 - human gene knockout kit via CRISPR

IRF8 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

IRF8 - human gene knockout kit via CRISPR

IRF8 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Irf8 - mouse gene knockout kit via CRISPR

Irf8 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Irf8 - mouse gene knockout kit via CRISPR

Irf8 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Irf8 - mouse gene knockout kit via CRISPR

Irf8 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Irf8 - mouse gene knockout kit via CRISPR

Irf8 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

IRF8 / ICSBP1

  Recombinant protein of human interferon regulatory factor 8 (IRF8)  
IRF8 / ICSBP1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

IRF8 overexpression lysate

IRF8 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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