IRS1 antibody

Principal name

IRS1 antibody

Alternative names for IRS1 antibody

Insulin receptor substrate 1, IRS-1

SwissProt ID

P35568 (Human), P35569 (Mouse), P35570 (Rat)

Gene ID

3667 (IRS1), 16367 (Irs1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Mky (Monkey), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Enzyme Immunoassay (E), Dot blot (Dot), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of IRS1 antibody

The insulin receptor substrate-1 (IRS-1), a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor. The association of 14-3-3 with IRS-1 increases significantly upon treatment with okadaic acid, a potent serine/ threonine phosphatase inhibitor. Therefore, the association of 14-3-3 protein may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IRS1 antibody

  IRS1 mouse monoclonal antibody, clone OTI2B10 (formerly 2B10)  
Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-IRS1 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808550)(1:150) Mouse IgG1 OTI2B10 Purified Hu P, WB
0.1 ml / €350.00
  OriGene Technologies, Inc.

TrueMAB

IRS1 antibody

  IRS1 mouse monoclonal antibody, clone OTI9E11 (formerly 9E11)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-IRS1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808552)(1:150) Mouse IgG2a OTI9E11 Purified Hu P, WB
0.1 ml / €350.00
  OriGene Technologies, Inc.

TrueMAB

IRS1 antibody

  IRS1 mouse monoclonal antibody, clone OTI3G10 (formerly 3G10)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-IRS1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808553)(1:150) Mouse IgG1 OTI3G10 Purified Hu P, WB
0.1 ml / €350.00
  OriGene Technologies, Inc.

TrueMAB

IRS1 pSer794 antibody

Immunohistochemistry (IHC) analysis of IRS-1 pSer794 antibody Cat.-No AP01831PU-N in paraffin-embedded human breast carcinoma at 1/100. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €380.00
  OriGene Technologies GmbH

IRS1 pSer636 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using IRS-1 antibody (AP02488PU-S; AP02488PU-N). Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €320.00
  OriGene Technologies GmbH

IRS1 pSer636 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using IRS-1 antibody (AP02488PU-S; AP02488PU-N). Rabbit Aff - Purified Hu, Ms P, WB
50 µg / €240.00
  OriGene Technologies GmbH

IRS1 pSer639 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using IRS-1 antibody (AP02489PU-S, AP02489PU-N). Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €320.00
  OriGene Technologies GmbH

IRS1 pSer639 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using IRS-1 antibody (AP02489PU-S, AP02489PU-N). Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €240.00
  OriGene Technologies GmbH

IRS1 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using IRS-1 antibody. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €320.00
  OriGene Technologies GmbH

IRS1 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using IRS-1 antibody. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µg / €240.00
  OriGene Technologies GmbH

IRS1 antibody

Western blot (WB) analysis of IRS-1 antibody (Cat.-No.: AP06397PU-N) in extracts from A431 or 293 cell treated with UV 30’. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  OriGene Technologies GmbH

IRS1 antibody

Immunohistochemistry (IHC) analyzes of IRS-1 antibody (Cat.-No.: AP06432PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
0.1 mg / €350.00
  OriGene Technologies GmbH

IRS1 antibody

Immunohistochemistry (IHC) analysis of IRS-1 antibody (Cat.-No.: AP06529PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  OriGene Technologies GmbH

IRS1 antibody

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
50 µg / €380.00
  OriGene Technologies GmbH

IRS1 antibody

Immunohistochemistry (IHC) analyzes of IRS-1 antibdoy (Cat.-No.: AP20694PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
0.1 mg / €350.00
  OriGene Technologies GmbH

IRS1 antibody

Immunohistochemistry analyzes of IRS-1 antibody (Cat.-No.: AP20695PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  OriGene Technologies GmbH

IRS1 antibody

Immunohistochemistry analysis of human breast carcinoma tissue (Formalin-fixed, Paraffin-embedded) using IRS1 antibody (Cat.-No. AP20709PU-N). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
0.1 mg / €350.00
  OriGene Technologies GmbH

IRS1 antibody

Immunohistochemistry analyzes of IRS-1 antibody (Cat.-No.: AP20710PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  OriGene Technologies GmbH

IRS1 pSer307 antibody

Immunohistochemistry (IHC) analyzes of p-IRS-1 antibody (Cat.-No.: AP20817PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  OriGene Technologies GmbH

IRS1 pSer636 antibody

Immunohistochemistry (IHC) analyzes of p-IRS-1 antibody (Cat.-No.: AP20831PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  OriGene Technologies GmbH

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