IRS2 antibody

Principal name

IRS2 antibody

Alternative names for IRS2 antibody

Insulin receptor substrate 2, IRS-2

SwissProt ID

P81122 (Mouse), Q9Y4H2 (Human)

Gene ID

8660 (IRS2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Dot blot (Dot)

Background of IRS2 antibody

Insulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit (2-3). Sequences of IRS-2 and IRS-1 reveal a highly conserved amino terminus containing a pleckstrin-homology domain and a phosphotyrosine-binding domain, and a poorly conserved carboxy terminus containing several tyrosine phosphorylation motifs. IRS-2 is expressed in many cells, including tissues from IRS-1-/- mice, and may be essential for signaling by several receptor systems such as insulin and cytokine (1).

12 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IRS2 (C-term) antibody

Western blot analysis of anti-IRS2 Antibody (C-term) (Cat.#TA324988) in 293 cell line lysates (35ug/lane). IRS2 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

IRS2 pTyr978 antibody

Dot blot analysis of anti-Phospho-IRS2 pTyr978 Antibody (Cat.#AP13006PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. Rabbit Ig Aff - Purified Hu
0.4 ml / €370.00
  Acris Antibodies GmbH

IRS2 antibody

Immunoblot analysis of SK-N-MC cell lysates. Mouse AF2F2 Hu E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

IRS2 pSer731 antibody

The cell lysate derived from conditioned NIH/3T3 was immunoprecipitated by IRS2 ( phospho S731 ) polyclonal antibody ( Cat # PAB12629 ), then immunoprobed by the same antibody at 1 : 500 ( lane 1 ). Lane 2 is a negative control. Rabbit Hu, Ms, Rt C, Dot, E, IP, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

IRS2 antibody

IRS2 Rabbit Hu, Ms, Rt C, E, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

IRS2 antibody

The cell lysate derived from conditioned NIH/3T3 was immunoprecipitated by IRS2 polyclonal antibody ( Cat # PAB12697 ), then immunoprobed by the same antibody at 1 : 500 ( lane 1 ). Lane 2 is a negative control. Rabbit Hu, Ms, Rt C, Dot, E, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

IRS2 antibody

Western Blot and  Immunoprecipitation: IRS2 Antibody [NB100-68242] - Detection of Human IRS2 NB100-68242. IRS2 was also immunoprecipitated by rabbit anti-IRS2 antibodies NB100-68243 and NB100-68244. Rabbit IgG Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

IRS2 antibody

Western Blot and  Immunoprecipitation: IRS2 Antibody [NB100-68243] - Detection of Human IRS2 NB100-68243. IRS2 was also immunoprecipitated by rabbit anti-IRS2 antibodies NB100-68242 and NB100-68244. Rabbit IgG Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

IRS2 antibody

Western Blot: IRS2 Antibody [NB100-68244] - Detection of Human IRS2 by Western Blot of  Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP,  20% of IP loaded) from HeLa cells. Antibodies: Affinity purified  rabbit anti-IRS2 antibody NB100-68244 used for IP at 3 mcg/mg  lysate. IRS2 was also immunoprecipitated by rabbit anti-IRS2  antibodies NB100-68242 and NB100-68243, which recognize  upstream epitopes. Detection: Chemiluminescence with  exposure times of 3 seconds (A) and 10 seconds (B). Rabbit IgG Aff - Purified Hu IP, P, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

IRS2 antibody

Immunohistochemistry: IRS-2 Antibody (EP903Y) [NB110-57138] - Immunohistochemical staining of paraffin-embedded human cervical carcinoma using anti-IRS-2 (cat. # 110-57138). Rabbit IgG EP903Y Aff - Purified Hu ICC/IF, IP, P, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

IRS2

IRS2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

IRS2

IRS2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

12 Item(s)

per page
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