IRS4 antibody

Principal name

IRS4 antibody

Alternative names for IRS4 antibody

Insulin receptor substrate 4, IRS-4, PY160, pp160, 160 kDa phosphotyrosine protein, Phosphoprotein of 160 kDa

SwissProt ID

O14654 (Human), Q9Z0Y7 (Mouse)

Gene ID

8471 (IRS4), 16370 (Irs4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P), Immunoprecipitation (IP)

Background of IRS4 antibody

A new member of the IRS family, IRS-4, is a 160-kDa tyrosine kinase which phosphorylates cellular substrates when it is activated by the binding of insulin (1). IRS-4 was originally discovered in human embryonic kidney 293 cells. Subcellular fractionation revealed that about 50% of IRS-4 was located in cellular membranes, and immunofluorescence indicated that IRS-4 was concentrated at the plasma membrane. Immunoelectron microscopy conclusively established that a large portion of the IRS-4 was located at the cytoplasmic surface of the plasma membrane in both the unstimulated and insulin-treated states. IRS-4 was found to be associated with two src homology 2 (SH2) domain-containing proteins, phosphatidylinositol 3-kinase and Grb2, the adaptor to the guanine nucleotide exchange factor for Ras (2).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IRS4 antibody

(0.2ug/ml) staining of Mouse Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Purified Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRS4 antibody

Predicted cell location: Cytoplasm. Positive control: Human liver cancer tissue. Recommended dilution: 1/20-100  The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using IRS4 antibody at dilution 1/17, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

IRS4 antibody

IRS4 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

IRS4 antibody

IRS4 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

IRS4 antibody

IRS4 monoclonal antibody (M01), clone 5B9 Western Blot analysis of IRS4 expression in HeLa ( Cat # L013V1 ). Mouse IgG1 5B9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

IRS4 antibody

Immunoblot analysis of 293T cell lysate. Rabbit Hu WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

IRS4 (C-term) antibody

Immunohistochemistry: IRS-4 (C-term) Antibody (EP907Y) [NB110-57140] - Immunohistochemical staining of paraffin-embedded human kidney using anti-IRS-4 (cat. #110-57140). Rabbit IgG EP907Y Aff - Purified Hu F, IP, P, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

IRS4

IRS4 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

IRS4

IRS4 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates (Overexpressed)

Catalog No.    

IRS4 overexpression lysate

IRS4 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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