IRX4 / IRXA3 antibody

Principal name

IRX4 / IRXA3 antibody

Alternative names for IRX4 / IRXA3 antibody

Iroquois homeobox protein 4, IRX-4, Iroquois-class homeodomain protein IRX-4, Homeodomain protein IRXA3

SwissProt ID

P78413 (Human), Q9QY61 (Mouse), Q9YGS0 (Chick)

Gene ID

50805 (IRX4)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), African clawed frog

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of IRX4 / IRXA3 antibody

The Iroquois homeobox gene family of transcription factors regulate aspects of embryonic development including anterior/posterior and dorsal/ventral axis patterning in the central nervous system. The Iroquois family are clustered on two loci, IRXA and IRXB, which map to chromosomes 8 and 13 in mice. The IRXA group includes Irx1, Irx2 and Irx4; the IRXB group is comprised of Irx3, Irx5 and Irx6. Irx1 and Irx2 are both widely expressed during development in the lung epithelium and also in the ventricular septum. Irx1 and Irx2 also play a role in digit formation (E11.5–E14.5). The Irx gene family members are each expressed in a distinct pattern during mouse heart development. Specifically, Irx1 and Irx2 are expressed in the ventricular septum and Irx3 is expressed in the ventricular trabeculated myocardium. In addition, Irx4 is expressed in the linear heart tube and the AV canal, and Irx5 is expressed in the endocardium lining the ventricular and atrial myocardium. Furthermore, the IRX4 gene may modulate cardiac development and function. Although the heart of Irx4(-) mice appears to develop normally, adult Irx4(-) mice exhibit cardiomyopathy, including cardiac hypertrophy and decreased contractility.

General readings

Wang,G.F., (2001) J. Biol. Chem. 276 (31), 28835-28841

3 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IRX4 / IRXA3 antibody

WB Suggested Anti-IRX4 Antibody Titration: 2.5ug/ml; Positive Control: Jurkat cell lysate Rabbit Aff - Purified African clawed frog, Bov, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

IRX4 / IRXA3 antibody

Human Jurkat; WB Suggested Anti-IRX4 Antibody Titration: 2.5ug/ml. Positive Control: Jurkat cell lysate; IRX4 antibody - N-terminal region (ARP32066_T100) in Human Jurkat cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Hu, Ms, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

Lysates (Overexpressed)

Catalog No.    

IRX4 overexpression lysate

IRX4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

3 Item(s)

per page
  • LinkedIn