JAMP antibody

Principal name

JAMP antibody

Alternative names for JAMP antibody

C14orf100, CDA06, HSPC213, HSPC327, JKAMP, JNK1/MAPK8-associated membrane protein, Medulloblastoma antigen MU-MB-50.4

SwissProt ID

Q8BI36 (Mouse), Q9P055 (Human)

Gene ID

51528 (JKAMP)

Available reactivities

Hu (Human)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of JAMP antibody

JAMP, better known as the JNK1/MAPK8 associated membrane protein, is a regulator of MAPK8 activity in response to various stress stimuli. This regulation is part of a broader response to ER stress which induces JAMP to facilitate the degradation of misfolded ER lumil proteins via recruitment of the ERAD (endoplasmic reticulum-associated degradation system). Aside from interactions with MAPK8, JAMP also interacts with RNF5, as well as many regulatory proteins in the ERAD such as AMFR/GP78, CANX, PSMC1/PSMC2 and PSMC5-8. JAMP is expressed in many tissues, including brain, spleen, thymus, liver, kidney and testis. It also exhibits elevated expression in medulloblastomas. JAMP undergoes a post-translatiol modification after ubiquitition by RNF5 in a UBE2N-dependent manner, which ultimately decreases association with the proteasome and ERAD. Research has confirmed that JAMP regulates JNK-1 activity (PMID: 16166642) as well as optimizes ERAD to protect cells from unfolded proteins (PMID 18784250) which may have various implications in disease models.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

JAMP antibody

Western Blot: JAMP Antibody [TA337226] - Western blot analysis of JAMP in HEK293 and A431 cell lysates. Rabbit Purified Hu C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

JAMP antibody

Immunohistochemistry-Paraffin: JAMP Antibody [NBP1-89906] Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

JAMP

JAMP Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

JAMP

JAMP Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

JKAMP overexpression lysate

JKAMP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

JKAMP overexpression lysate

JKAMP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

JKAMP overexpression lysate

JKAMP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

7 Item(s)

per page
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