KCNA1 antibody

Principal name

KCNA1 antibody

Alternative names for KCNA1 antibody

HUKI, HBK1, Potassium voltage-gated channel subfamily A member 1, Voltage-gated potassium channel subunit Kv1.1

SwissProt ID

P10499 (Rat), P16388 (Mouse), Q09470 (Human)

Gene ID

3736 (KCNA1), 24520 (Kcna1), 16485

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Por (Porcine), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P)

Background of KCNA1 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Kv1.1, also known as potassium voltage-gated channel subfamily A member 1, is a shaker related voltage potassium channel that in humans is encoded by the SCNA1 gene (3-5).
It is strongly expressed in a variety of neurons in adult rodents, and it appears to be involved in regulating neuronal excitability. Specifically it plays a role in several developmental processes including proliferation, migration and cell-cell adhesion (6). The Isaacs syndrome is a result of an autoimmune reaction against the Kv1.1 ion channel (7).

General readings

1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd
Ed., Sinauer Associated Inc.: Sunderland, MA USA.
2. Curran M.E., Landes G.M. and Keating M.T. (1992)
Genomics. 12(4): 729-737.
3. Albrecht B., Weber K. and Pongs O. (1995) Recept.
Channels. 3(3): 213-220.
4. Gutman G.A., et al. (2005) Pharmacol Rev. 57(4): 473-
508.
5. Hallow J.L., Tempel B.L. (1998) J Neurosci. 18(15): 5682-
5691.
6. Newsom-Davis J. (1997) Ann N.Y. Acad Sci. 835: 111-119.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNA1 antibody

immunoblot against crude brain membranes from adult rat (RBM) and Kv1.1 wild-type (WT) or knock-out (KO) mouse probed with K20/78 (left) or N52A/42 (right) TC supe. Mouse IgG1 K20/78 Supernatant Hu, Ms, Rt C, ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNA1 antibody

Adult brain membrane immunoblot Mouse IgG2b K36/15 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNA1 antibody

immunoblot against crude brain membranes from adult rat (RBM) and Kv1.1 wild-type (WT) or knock-out (KO) mouse probed with K20/78 (left) or N52A/42 (right) TC supe. Mouse IgG1 K20/78 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNA1 antibody

Adult brain membrane immunoblot Mouse IgG2b K36/15 Purified Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNA1 antibody

Western blot analysis of extracts from HeLa cells, MCF-7 cells and HuvEc cells, using KCNA1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNA1 antibody

Predicted band size: 56 kDa . Positive control: Human kidney cancer tissue lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/600 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNA1 antibody

Predicted band size: 56 kDa . Positive control: Human brain malignant glioma tissue lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNA1 antibody

IHC analysis of Kv1.1 using the antibody Mouse IgG1 S20-78 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNA1 antibody

IHC analysis of Kv1.1 (extracellular) in frozen sections of mouse brain extract using the antibody Mouse IgG2b S36-15 Purified Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNA1 antibody

Western blot analysis of rat brain membranes: 1. Anti-Kv1.1 antibody , (1:200). 2. Anti-Kv1.1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNA1 antibody

WB Suggested Anti-KCNA1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Stomach Rabbit IgG Purified Can, Eq, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNA1 (458-476) antibody

Immunohistochemistry analysis of Kv1.1 using KCNA1 antibody Cat.-No AM20091PU-N in mouse backskin sections. Courtesy of Dr. Turksen, Ottawa Hospital Research Institute, Canada. Mouse IgG1 S20-78 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

KCNA1 (191-208) antibody

KCNA1 Mouse IgG2b S36-15 Purified Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

KCNA1 antibody

Western blot analysis using Kv1.1 antibody on rat brain lysate. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €360.00
  Acris Antibodies GmbH

KCNA1 (Center) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissuereacted with KCNA1 Antibody (Center) Cat.-No AP52298PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

KCNA1 antibody

KCNA1 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

KCNA1 antibody

Western Blot analysis of KCNA1 expression in transfected 293T cell line (H00003736-T01) by KCNA1 MaxPab polyclonal antibody.

Lane 1: KCNA1 transfected lysate(54.45 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

KCNA1 antibody

KCNA1 Mouse IgG2a 2D8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

KCNA1 antibody

Western blot analysis using Kcna1 polyclonal antibody ( Cat # PAB10100 ) on rat brain lysate. Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

KCNA1 antibody

Western blot analysis of extracts from HuvEc/MCF-7/HeLa cells, using KCNA1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

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