KCNA10 antibody

Principal name

KCNA10 antibody

Alternative names for KCNA10 antibody

Potassium voltage-gated channel subfamily A member 10, Voltage-gated potassium channel subunit Kv1.8

SwissProt ID

Q16322 (Human), Q7T199 (Chick)

Gene ID

3744 (KCNA10)

Available reactivities

Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E)

Background of KCNA10 antibody

Potassium (K+) channels regulate cell membrane potential and modulate a number of important cellular functions. K+ voltage-gated channel subfamily A member 10 (KC10) also known as KV1.8 is a voltage-gated K+ (KV) channel gene related to the Shaker family of K+ channels that includes eight members (KV1.1- KV1.8). KV1.8 contains six membrane-spanning domains with a shaker-type repeat in the fourth segment and a pore (P) region. Its most distinguishing feature is the presence of a putative cyclic nucleotide-binding (CNB) domain at the COOH terminus. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. The channel displays an unusual inhibitor profile, because in addition to being blocked by classical K+ channel blockers, it is also sensitive to inhibitors of cyclic nucleotide gated cation channel such as verapamil and pimozide. KV1.8 is detected in kidney, heart, and aorta by Northern blot and postulated to participate in rel K+ metabolism and to regulate vascular tone. A recent study showed that a mutation of mouse KC10 causes significant vestibular and mild hearing dysfunction. In addition KC10 has been associated with Long QT syndrome (LQTS), an arrhythmogenic disorder characterized by prolongation of the QT interval on electrocardiograms (ECGs).

General readings

Yao,X., et al., (2002) J. Am. Soc. Nephrol. 13 (12), 2831-2839

8 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNA10 antibody

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) heart lysates: 1-2. Anti-KV1.8 antibody, (1:800). 3-4. Anti-KV1.8 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNA10 antibody

WB Suggested Anti-KCNA10 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNA10 antibody

WB Suggested Anti-KCNA10 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1:312500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNA10 antibody

KCNA10 Rabbit Purified Hu, Ms, Rt C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

KCNA10 antibody

Human Heart; Heart; KCNA10 antibody - N-terminal region (ARP35177_P050) in Human Heart cells using Immunohistochemistry Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

KCNA10 antibody

Human kidney; KCNA10 antibody - middle region (ARP35178_T100) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified Chk, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

KCNA10 antibody

Immunohistochemistry-Paraffin: KCNA10 Antibody [NBP1-81338] - Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

KCNA10 overexpression lysate

KCNA10 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

8 Item(s)

per page
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