KCNA2 antibody

Principal name

KCNA2 antibody

Alternative names for KCNA2 antibody

Potassium voltage-gated channel subfamily A member 2, Voltage-gated potassium channel subunit Kv1.2, HBK5, NGK1, HUKIV, KCNA2

SwissProt ID

P16389 (Human), P22739 (Xenla), P63141 (Mouse), P63142 (Rat), Q09081 (Rabit), Q28293 (Canfa)

Gene ID

3737 (KCNA2), 16490 (Kcna2), 25468

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Xen (Xenopus), Ze (Zebrafish), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Neutralisation (NEUT), Frozen Sections (C), Paraffin Sections (P)

Background of KCNA2 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Voltage gated channels are tetrameters composed of four alpha-subunits arranged around a central pore. Each alpha- subunit consists of six transmembrane segments with cytoplasmic NH2 and COOH-termini. Members of the KV1-KV4 subfamilies generate functional K+ channels in a homotetrameric configuration (3).

General readings

Denning, E.J., et al. Mol. Membr. Biol. 26(8):397-421(2009)
Peters, C.J., et al. Channels (Austin) 3(5):314-322(2009)
Martos, V., et al. Proc. Natl. Acad. Sci. U.S.A. 106(26):10482-10486(2009)
Stirling, L., et al. Mol. Biol. Cell 20(12):2991-3002(2009)
Zhu, J., et al. Biochem. J. 375 (PT 3), 769-775 (2003)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNA2 antibody

adult rat brain membrane immunoblot. Mouse IgG2b K14/16 Supernatant Hu, Ms, Rt, Xen, Ze C, ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNA2 antibody

adult rat brain membrane immunoblot. Mouse IgG2b K14/16 Purified Hu, Ms, Rt, Xen, Ze C, ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNA2 antibody

Western Blot: Kv1.2 Antibody - Membrane preparations from HEK-293 cells untransfected (lane 1), transfected with Kv1.2 (lanes 2 and 4) and transfected with Kv1.3 (lane 3) were subjected to 10% SDS-PAGE and were Western blotted with the Kv1.2 Antibody . Lane 4 was probed with anti-Kv 1.2 that had been preincubated with the peptide used to generate the antibody. Rabbit Purified Bov, Can, Hu, Ms, Por, Rb, Rt, Xen IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNA2 antibody

Immunocytochemistry: Kv1.2 Antibody - Detection of Kv1.2 (Green) in 293 human embryonic kidney cells using anti-Kv 1.2.  Nuclei (Blue) are counterstained using Hoechst 33258. Rabbit Purified Bov, Can, Hu, Ms, Por, Rt, Xen, Ze ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNA2 antibody

IHC analysis of Kv1.2 in frozen sections of mouse brain extract using the antibody Mouse IgG2b S14-16 Purified Hu, Ms, Rt, Xen, Ze C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNA2 antibody

Western blot analysis of rat brain membranes: 1. Anti-KV1.2 antibody , (1:200). 2. Anti-KV1.2 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNA2 antibody

Western Blot: Kv1 Antibody [TA336756] - Membrane preparations from HEK-293 cells untransfected (lane 1) transfected with Kv1.2 (lanes 2 and 4) and transfected with Kv1.3 (lane 3) were subjected to 10% SDS-PAGE and were Western blotted with Kv1 Antibody (T Rabbit Purified Bov, Can, Hu, Ms, Por, Rt IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNA2 antibody

Adult rat brain membrane immunoblot Mouse IgG2a L76/36 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNA2 antibody

Adult rat brain membrane immunoblot Mouse IgG2a L76/36 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNA2 (428-499) antibody

KCNA2 Mouse IgG2b S14-16 Purified Hu, Ms, Rt, Xen, Ze C, ICC/IF, IP, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

KCNA2 antibody

KCNA2 Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €360.00
  Acris Antibodies GmbH

KCNA2 (C-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue reacted with AP52299PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

KCNA2 antibody

KCNA2 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

KCNA2 antibody

KCNA2 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

KCNA2 antibody

KCNA2 Rabbit Hu, Ms, Rt E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

KCNA2 antibody

KCNA2 Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

KCNA2 antibody

Kv1.2 staining of adult rat hippocampus. Mouse IgG2a Aff - Purified Hu, Ms, Rt, Xen, Ze C, ICC/IF, IP, WB
0.1 ml / €440.00
  Neuromics Antibodies

KCNA2 (50-100) antibody

KCNA2 Rabbit Biotin Bov, Can, Hu, Ms, Por, Rt, Xen, Ze IP, WB
0.1 ml / €360.00
  Novus Biologicals Inc.

KCNA2 (50-100) antibody

KCNA2 Rabbit DyLight650 Bov, Can, Hu, Ms, Por, Rt, Xen, Ze IP, WB
0.1 ml / €390.00
  Novus Biologicals Inc.

KCNA2 antibody

KCNA2 Rabbit DyLight488 Bov, Can, Hu, Ms, Por, Rt, Xen, Ze IP, WB
0.1 ml / €390.00
  Novus Biologicals Inc.

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