KCNA3 antibody

Principal name

KCNA3 antibody

Alternative names for KCNA3 antibody

Potassium voltage-gated channel subfamily A member 3, Voltage-gated potassium channel subunit Kv1.3, HPCN3, HGK5, HuKIII, HLK3

SwissProt ID

P15384 (Rat), P16390 (Mouse), P22001 (Human)

Gene ID

3738 (KCNA3), 29731 (Kcna3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C), Immunoprecipitation (IP)

Background of KCNA3 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotidegated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Voltage gated channels are tetrameters composed of four alpha-subunits arranged around a central pole. Each alphasubunit consists of six transmembrane segments with cytoplasmic NH2 and COOH-termini. Members of the KV1-4 subfamilies generate functional K+ channels in a homotetrameric configuration (3).

General readings

Wang, T., et al. J. Neurosci. 30(14):5020-5027(2010)
Tu, L.W., et al. J. Mol. Biol. 396(5):1346-1360(2010)
Poulopoulou, C., et al. Neurobiol. Dis. 37(2):339-348(2010)
Nicolaou, S.A., et al. Cell Calcium 47(1):19-28(2010)
Feng, D.Y., et al. Zhonghua Xin Xue Guan Bing Za Zhi 37(7):599-604(2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNA3 antibody

Adult rat brain membrane immunoblot Mouse IgG1 L23/27 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNA3 antibody

Adult rat brain membrane immunoblot Mouse IgG1 L23/27 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNA3 antibody

IHC analysis of Kv1.3 in frozen sections of mouse brain extract using the antibody Mouse IgG2a S23-27 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNA3 antibody

Western blot analysis of rat brain membranes: 1. Anti-Kv1.3 antibody, (1:200) 2. Anti-Kv1.3 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNA3 antibody

Western blot analysis of rat brain membranes: 1. Anti-Kv1.3 (extracellular) antibody, (1:500). 2. Anti-Kv1.3 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNA3 antibody

Anti-KCNA3 / Kv1.3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

KCNA3 antibody

Anti-KCNA3 / Kv1.3 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

KCNA3 antibody

Western blot analysis using Kv1.3 antibody on rat brain lysate. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €360.00
  Acris Antibodies GmbH

KCNA3 antibody

Immunohistochemistry analyzes of Kv1.3 antibody (AP20254PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

KCNA3 (Center) antibody

Western blot analysis of KCNA3 Antibody (Center) Cat.-No AP52300PU-N in A549 cell line lysates (35ug/lane).This demonstrates the KCNA3 antibody detected the KCNA3 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

KCNA3 antibody

KCNA3 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

KCNA3 antibody

KCNA3 monoclonal antibody (M01), clone 1D8 Western Blot analysis of KCNA3 expression in HeLa NE ( Cat # L013V3 ). Mouse IgG1 1D8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

KCNA3 antibody

Western blot analysis using Kcna3 polyclonal antibody ( Cat # PAB10102 ) on rat brain lysate. Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

KCNA3 pTyr135 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Kv1.3/KCNA3 (Phospho-Tyr135) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

KCNA3 pTyr135 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Kv1.3/KCNA3 (Phospho-Tyr135) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

KCNA3 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Kv1.3/KCNA3 (Ab-135) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

KCNA3 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Kv1.3/KCNA3 (Ab-135) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €310.00
  Assay Biotech

KCNA3 pTyr187 antibody

Western blot analysis of Kv1.3 (pY187) expression in HEK293T EGF-treated (A); SP2/0 EGF-treated (B); PC12 EGF-treated (C) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rb, Rt WB
30 µl / €210.00
  Cohesion Biosciences Ltd.

KCNA3 pTyr187 antibody

Western blot analysis of Kv1.3 (pY187) expression in HEK293T EGF-treated (A); SP2/0 EGF-treated (B); PC12 EGF-treated (C) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rb, Rt WB
0.1 ml / €330.00
  Cohesion Biosciences Ltd.

KCNA3 pTyr187 antibody

Western blot analysis of Kv1.3 (pY187) expression in HEK293T EGF-treated (A); SP2/0 EGF-treated (B); PC12 EGF-treated (C) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rb, Rt WB
0.2 ml / €530.00
  Cohesion Biosciences Ltd.

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