KCNA3 antibody

Principal name

KCNA3 antibody

Alternative names for KCNA3 antibody

Potassium voltage-gated channel subfamily A member 3, Voltage-gated potassium channel subunit Kv1.3, HPCN3, HGK5, HuKIII, HLK3

SwissProt ID

P15384 (Rat), P16390 (Mouse), P22001 (Human)

Gene ID

3738 (KCNA3), 29731 (Kcna3), 16491

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C), Immunoprecipitation (IP)

Background of KCNA3 antibody

The Kv1.3 potassium channel is a voltage-gated channel protein which belongs to the delayed rectifier class and to the Shaker potassium channel subfamily which includes Kv1.1, Kv1.2, Kv1.4 and Kv1.5. Potassium channels are mainly found in plasma membranes but are not generally distributed over the cell surface. Potassium channels catalyze the rapid permeation of potassium ions while rejecting biologically abundant potential competitors such as sodium, calcium and magnesium. Ion selectivity and high through put rate of potassium channels is accomplished by precise co-ordination of dehydrated potassium by the protein and multiple ion occupancy within the permeation pathway. All potassium channels carry out the formation of a transmembrane leak specific for potassium ions. Since cells almost universally maintain cytoplasmic potassium concentrations higher than those extracellularly, the opening of a potassium channel implies a negative ongoing change in electrical voltage across the cell membrane. This may result in termination of the action potential of electrically excitable cells including nerve, muscle and pancreatic beta cells. In non–excitable cells, potassium channels play important roles in the cellular potassium recycling required for electrolyte balance effected by the renal epithelium.

General readings

Wang, T., et al. J. Neurosci. 30(14):5020-5027(2010)
Tu, L.W., et al. J. Mol. Biol. 396(5):1346-1360(2010)
Poulopoulou, C., et al. Neurobiol. Dis. 37(2):339-348(2010)
Nicolaou, S.A., et al. Cell Calcium 47(1):19-28(2010)
Feng, D.Y., et al. Zhonghua Xin Xue Guan Bing Za Zhi 37(7):599-604(2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNA3 antibody

Adult rat brain membrane immunoblot Mouse IgG1 L23/27 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €460.00
  Antibodies Incorporated

NeuroMab

KCNA3 antibody

Adult rat brain membrane immunoblot Mouse IgG1 L23/27 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €540.00
  Antibodies Incorporated

NeuroMab

KCNA3 antibody

  Mouse monoclonal Kv1.3 Antibody  
IHC analysis of Kv1.3 in frozen sections of mouse brain extract using the antibody Mouse IgG2a S23-27 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNA3 antibody

  Rabbit Polyclonal Anti-KV1.3  
Western blot analysis of rat brain membranes: 1. Anti-Kv1.3 antibody, (1:200) 2. Anti-Kv1.3 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNA3 antibody

  Rabbit Polyclonal Anti-KV1.3 (extracellular)  
Western blot analysis of rat brain membranes: 1. Anti-Kv1.3 (extracellular) antibody, (1:500). 2. Anti-Kv1.3 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNA3 antibody

  Rabbit Polyclonal Anti-KCNA3 Antibody (Internal)  
Anti-KCNA3 / Kv1.3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €400.00
  OriGene Technologies, Inc.

KCNA3 antibody

  Rabbit Polyclonal Anti-KCNA3 Antibody (C-Terminus)  
Anti-KCNA3 / Kv1.3 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €400.00
  OriGene Technologies, Inc.

KCNA3 antibody

Western blot analysis using Kv1.3 antibody on rat brain lysate. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €370.00
  Acris Antibodies GmbH

KCNA3 antibody

Immunohistochemistry analyzes of Kv1.3 antibody (AP20254PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

KCNA3 (Center) antibody

Western blot analysis of KCNA3 Antibody (Center) Cat.-No AP52300PU-N in A549 cell line lysates (35ug/lane).This demonstrates the KCNA3 antibody detected the KCNA3 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

KCNA3 antibody

KCNA3 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

KCNA3 pTyr135 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Kv1.3/KCNA3 (Phospho-Tyr135) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €230.00
  Assay Biotech

KCNA3 pTyr135 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Kv1.3/KCNA3 (Phospho-Tyr135) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €330.00
  Assay Biotech

KCNA3 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Kv1.3/KCNA3 (Ab-135) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €230.00
  Assay Biotech

KCNA3 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Kv1.3/KCNA3 (Ab-135) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €330.00
  Assay Biotech

KCNA3 (485-506) antibody

Kv1.3 staining of (A)adult rat dentate gyrus and (B) hippocampus. Mouse IgG1 Aff - Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €440.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

Kcna3 - mouse gene knockout kit via CRISPR

Kcna3 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Kcna3 - mouse gene knockout kit via CRISPR

Kcna3 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcna3 - mouse gene knockout kit via CRISPR

Kcna3 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcna3 - mouse gene knockout kit via CRISPR

Kcna3 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

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