KCNAB2 antibody

Principal name

KCNAB2 antibody

Alternative names for KCNAB2 antibody

Voltage-gated potassium channel subunit beta-2, Kv-beta-2, HKvbeta2, KCNA2B, KCNK2

SwissProt ID

P62482 (Mouse), P62483 (Rat), Q13303 (Human), Q27955 (Bovin), Q9PTM5 (Xenla)

Gene ID

8514 (KCNAB2), 16498 (Kcnab2), 29738

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Ye (Yeast)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of KCNAB2 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Depolarization-activated postassium channels (Kv) play a major role in shaping the electrical signals in the nervous system (3). KvBeta2, otherwise known as potassium voltagegated channel, shaker-related subfamily beta member 2, is encoded by the KCNAB2 gene in humans. The KvBeta channels are also members of the aldo-keto reductase (AKR) subfamily. These proteins regulated inactivation and membrane localization of Kv1 and Kv4 channels (4, 5). Specifically Kv2beta2 contributes to regulation of excitability in vivo, although not directly through either chaperone-like or typical AKR catalytic activity (5).

General readings

Gu,C., et al., (2003) Science 301 (5633), 646-649

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNAB2 antibody

  Rabbit polyclonal Anti-KCNAB2 Antibody  
WB Suggested Anti-KCNAB2 Antibody; Titration: 1.25ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ye, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNAB2 antibody

  Rabbit polyclonal Anti-KCNAB2 Antibody  
WB Suggested Anti-KCNAB2 Antibody Titration: 1.25ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ye, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNAB2 antibody

  Mouse Monoclonal anti-KCNA2B Antibody  
KCNAB2 Mouse IgG1 S17-70 Purified Hu, Ms, Rt, Ze C, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNAB2 antibody

  Rabbit polyclonal Anti-KVbeta2  
Western blot analysis of rat brain lysate (lanes 1 and 3) and membranes (lanes 2 and 4): 1, 2. Anti-Kvβ2 antibody , (1:200). 3, 4. Anti-Kvβ2 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNAB2 antibody

  Rabbit Polyclonal Anti-KCNAB2 Antibody  
WB Suggested Anti-KCNAB2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:2500; Positive Control: Jurkat cell lysate KCNAB2 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNAB2 antibody

  Rabbit Polyclonal Anti-KCNAB2 Antibody  
WB Suggested Anti-KCNAB2 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1:1562500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNAB2 antibody

Adult rat brain membrane immunoblot Mouse IgG1 K17/70 Supernatant Hu, Ms, Rt, Ze C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNAB2 antibody

Adult rat brain membrane immunoblot Mouse IgG1 K17/70 Purified Hu, Ms, Rt, Ze C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

CRISPR

Catalog No. Species Donor Vector  

KCNAB2 - human gene knockout kit via CRISPR

KCNAB2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

KCNAB2 - human gene knockout kit via CRISPR

KCNAB2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNAB2 - human gene knockout kit via CRISPR

KCNAB2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNAB2 - human gene knockout kit via CRISPR

KCNAB2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KCNAB2 (transcript variant 1)

  Recombinant protein of human potassium voltage-gated channel, shaker-related subfamily, beta member 2 (KCNAB2), transcript variant 1  
KCNAB2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

KCNAB2 (transcript variant 2)

  Recombinant protein of human potassium voltage-gated channel, shaker-related subfamily, beta member 2 (KCNAB2), transcript variant 2  
KCNAB2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KCNAB2 (mGFP-tagged) - Human potassium voltage-gated channel, shaker-related subfamily, beta member 2 (KCNAB2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNAB2 (mGFP-tagged) - Human potassium voltage-gated channel, shaker-related subfamily, beta member 2 (KCNAB2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNAB2 (mGFP-tagged) - Human potassium voltage-gated channel, shaker-related subfamily, beta member 2 (KCNAB2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNAB2 (mGFP-tagged) - Human potassium voltage-gated channel, shaker-related subfamily, beta member 2 (KCNAB2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €920.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNAB2 (Myc-DDK tagged) - Human potassium voltage-gated channel, shaker-related subfamily, beta member 2 (KCNAB2), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNAB2 (Myc-DDK tagged) - Human potassium voltage-gated channel, shaker-related subfamily, beta member 2 (KCNAB2), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNAB2 (Myc-DDK tagged) - Human potassium voltage-gated channel, shaker-related subfamily, beta member 2 (KCNAB2), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNAB2 (Myc-DDK tagged) - Human potassium voltage-gated channel, shaker-related subfamily, beta member 2 (KCNAB2), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €820.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Kcnab2 (GFP-tagged) - Mouse potassium voltage-gated channel, shaker-related subfamily, beta member 2 (Kcnab2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnab2 (GFP-tagged) - Mouse potassium voltage-gated channel, shaker-related subfamily, beta member 2 (Kcnab2), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Kcnab2 (Myc-DDK-tagged) - Mouse potassium voltage-gated channel, shaker-related subfamily, beta member 2 (Kcnab2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnab2 (Myc-DDK-tagged) - Mouse potassium voltage-gated channel, shaker-related subfamily, beta member 2 (Kcnab2), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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