KCNB1 antibody

Principal name

KCNB1 antibody

Alternative names for KCNB1 antibody

Potassium voltage-gated channel subfamily B member 1, Voltage-gated potassium channel subunit Kv2.1, mShab

SwissProt ID

O18868 (Pig), P15387 (Rat), Q03717 (Mouse), Q14721 (Human), Q9MZ19 (Rabit)

Gene ID

3745 (KCNB1), 25736 (Kcnb1), 2745 (GLRX)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Mky (Monkey), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P)

Background of KCNB1 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Voltage gated channels are tetrameters composed of four alpha-subunits arranged around a central pore. Each alpha- subunit consists of six transmembrane segments with cytoplasmic NH2 and COOH-termini. Members of the KV1-KV4 subfamilies generate functional K+ channels in a homotetrameric configuration. The KV2 subfaily consists of KV2.1 and KV2.2, and both have very similar properties. Members of the KV2 subfamily are widely expressed in neuronal tissues. They have also been reported in neurons in the dorsal root ganglia (3-5).

General readings

Adair,B., (2008) Biophys. J. 94 (6), 2106-2114

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNB1 antibody

immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)]. Mouse IgG1 K89/34 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNB1 antibody

immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)]. Mouse IgG1 K89/34 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNB1 antibody

IHC analysis of Kv2.1 tested on mouse brain hippocampus showing strong membrane staining of neurons, using a dilution of the antibody Mouse IgG1 S4-11 Purified Hu, Mky, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNB1 antibody

IHC analysis of kv2.1 using the antibody Mouse IgG2a S39-25 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNB1 antibody

Western blot analysis of Kv2.1 on rat brain membrane tissues using a 1:1000 dilution of the antibody Mouse IgG1 S89-34 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNB1 antibody

Western blot analysis of rat brain membranes: 1. Anti-Kv2.1 antibody , (1:500). 2. Anti-Kv2.1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNB1 antibody

WB Suggested Anti-KCNB1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNB1 antibody

Adult rat brain membrane immunoblot Mouse IgG2a K39/25 Supernatant Hu, Ms, Rt ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNB1 antibody

Adult rat brain membrane immunoblot Mouse IgG3 L80/21 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNB1 antibody

Transfected cell immunoblot: extracts of COS cells transiently transfected with untagged Boymaw or Kv2.1 plasmid and probed with L83/11 (left) or N52A/42 (right) TC supe. Mouse IgG2a L83/11 Supernatant Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNB1 antibody

Adult rat brain membrane immunoblot Mouse IgG2a K39/25 Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNB1 antibody

Adult rat brain membrane immunoblot Mouse IgG3 L80/21 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNB1 (11-229) antibody

KCNB1 Mouse IgG2a S39-25 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

KCNB1 antibody

KCNB1 Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €360.00
  Acris Antibodies GmbH

KCNB1 antibody

KCNB1 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

KCNB1 pSer805 antibody

Western blot analysis of extracts from K562 cells treated with TNF using Phospho-Kv2.1 (Ser805) antibody AP55879PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €340.00
  Acris Antibodies GmbH

KCNB1 pSer805 antibody

Western blot analysis of extracts from K562 cells treated with TNF using Phospho-Kv2.1 (Ser805) antibody AP55879PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €270.00
  Acris Antibodies GmbH

KCNB1 antibody

KCNB1 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

KCNB1 antibody

KCNB1 Goat Bov, Hu, Ms E
0.1 mg / €390.00
  Abnova Taiwan Corp.

KCNB1 pSer567 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Kv2.1/KCNB1 (Phospho-Ser567) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

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