KCNB2 antibody

Principal name

KCNB2 antibody

Alternative names for KCNB2 antibody

Potassium channel alpha subunit Kv2.2, XShab12

SwissProt ID

Q91592 (Xenla)

Gene ID

378534 (kcnb2-b)

Available reactivities

Rt (Rat)

Available hosts

Rabbit

Available applications

Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of KCNB2 antibody

Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety on non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al., 1993; Yan et al., 2004; Michaelevski et al., 2003). Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells (Blaine and Ribera, 1998; Burger and Ribera, 1996).

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