KCNB2 antibody

Principal name

KCNB2 antibody

Alternative names for KCNB2 antibody

Voltage-gated potassium channel subunit Kv2.2, Potassium voltage-gated channel subfamily B member 2

SwissProt ID

A6H8H5 (Mouse), Q4ZHA6 (Bovin), Q63099 (Rat), Q92953 (Human), Q95167 (Canfa), Q95L11 (Rabit)

Gene ID

9312 (KCNB2), 117105 (Kcnb2), 98741

Available reactivities

Ms (Mouse), Rt (Rat), Xen (Xenopus), Hu (Human)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of KCNB2 antibody

KV2.2 is a member of the voltage-gated K+ channel superfamily. Together with the closely related KV2.1 protein they form the KV2 subfamily also known as Shab. As with all KV channels, KV2.2 possesses the sigture structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. The functiol KV channel is a tetramer that can either be a homotetramer or a heteromer of KV2.2 and KV2.1 subunits.Both KV2.2 and KV2.1 channels are known as delayed rectifiers that is, channels that are activated by changes in membrane potential (depolarization) but ictivate very slowly. The current they form is known as IK or IDR. Accessory subunits such as KChaP and the electrically silent a subunits KV8 and KV9 can modulate biochemical and biophysical properties of KV2.2. KV2.2 is expressed in the brain and in peripheral tissues such as gastrointestil and vascular smooth muscle. Physiologically, KV2.2 has a role in maintaining membrane potential and in modulating electrical excitability in neurons. In smooth muscle cells, KV2.2 is probably involved in maintaining the contractile capacity of the cells.The pharmacology of the KV2.2 channel is somewhat limited. The channel is blocked by the classical K+ channel blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP). More recently, the small peptide toxin Stromatoxin-1 has been found to be a potent and more specific inhibitor of the KV2 subfamily.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNB2 antibody

  Rabbit Anti-Potassium Channel, Voltage Gated, Kv2.2 Subunit Antibody  
Western blot of rat brain homogenate showing specific immunolabeling of the ~125k voltage-gated potassium channel, Kv2.2 (Control). The immunolabeling is blocked by preadsorption with the peptide used as antigen (Peptide Block). Rabbit IgG Aff - Purified Rt, Xen C, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNB2 antibody

immunoblot against adult rat brain membranes (RBM) and membranes from Kv2.2 wild-type (WT) and knockout (KO) mice probed with K37/89 (left) or K89/34 TC supe. Mouse brains courtesy of Amy Huntley and Jeanne Nerbonne (Washington University). Mouse IgG2a K37/89 Supernatant Hu, Ms, Rt C, ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNB2 antibody

immunoblot against adult rat brain membranes (RBM) and membranes from Kv2.2 wild-type (WT) and knockout (KO) mice probed with K37/89 (left) or K89/34 TC supe. Mouse brains courtesy of Amy Huntley and Jeanne Nerbonne (Washington University). Mouse IgG2a K37/89 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNB2 antibody

  Mouse Monoclonal Anti-Kv2.2 Antibody  
IHC analysis of Kv2.2 in frozen sections of mouse brain extract using the antibody Mouse IgG2a S37-89 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNB2 antibody

  Rabbit polyclonal Anti-KV2.2  
Western blot analysis of rat brain lysate: 1. Anti-Kv2.2 antibody , (1:2000). 2. Anti-Kv2.2 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNB2 antibody

Adult rat brain immunohistochemistry Mouse IgG1 N372C/51 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNB2 antibody

Immunofluorescence staining of adult wild-type (WT) and Kv2.2 knockout (KO) mouse magnocellular preoptic nucleus (MCPO) with N372B/60 (red) and Hoechst nuclear stain (blue). Mouse IgG2b N372B/60 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNB2 antibody

Immunoblot against extracts of COS cells transiently transfected with GFP-tagged Kv2.2long, Myc-tagged Kv2.2short or untagged Kv2.1 plasmid; and adult brain membranes from rat (RBM), Kv2.2 wild-type (WT) and knockout (KO) mice probed with N372B/1 (left) or N52A/42 (right) TC supe. Mouse IgG1 N372B/1 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNB2 antibody

Immunoblot against extracts of COS cells transiently transfected with GFP-tagged Kv2.2long, Myc-tagged Kv2.2short or untagged Kv2.1 plasmid; and adult brain membranes from rat (RBM), Kv2.2 wild-type (WT) and knockout (KO) mice probed with N372B/1 (left) or N52A/42 (right) TC supe. Mouse IgG1 N372B/1 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNB2 antibody

Western blot analysis using Kv2.2 antibody on rat brain lysate in the absence and presence of antigen peptide. Rabbit IgG Aff - Purified Ms, Rt, Xen C, WB
10 Blots / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Kcnb2 - mouse gene knockout kit via CRISPR

Kcnb2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Kcnb2 - mouse gene knockout kit via CRISPR

Kcnb2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnb2 - mouse gene knockout kit via CRISPR

Kcnb2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnb2 - mouse gene knockout kit via CRISPR

Kcnb2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KCNB2 (mGFP-tagged)-Human potassium voltage-gated channel, Shab-related subfamily, member 2 (KCNB2), 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNB2 (mGFP-tagged)-Human potassium voltage-gated channel, Shab-related subfamily, member 2 (KCNB2), 200 uL, >10^7 TU/mL  
200 µl / €1,900.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNB2 (Myc-DDK-tagged)-Human potassium voltage-gated channel, Shab-related subfamily, member 2 (KCNB2), 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNB2 (Myc-DDK-tagged)-Human potassium voltage-gated channel, Shab-related subfamily, member 2 (KCNB2), 200 uL, >10^7 TU/mL  
200 µl / €1,710.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Kcnb2 (GFP-tagged) - Mouse potassium voltage gated channel, Shab-related subfamily, member 2 (Kcnb2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnb2 (GFP-tagged) - Mouse potassium voltage gated channel, Shab-related subfamily, member 2 (Kcnb2), 200 uL, >10^7 TU/mL  
200 µl / €1,660.00
  OriGene Technologies, Inc.

Lenti ORF particles, Kcnb2 (Myc-DDK-tagged) - Mouse potassium voltage gated channel, Shab-related subfamily, member 2 (Kcnb2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnb2 (Myc-DDK-tagged) - Mouse potassium voltage gated channel, Shab-related subfamily, member 2 (Kcnb2), 200 uL, >10^7 TU/mL  
200 µl / €1,490.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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