KCNB2 antibody

Principal name

KCNB2 antibody

Alternative names for KCNB2 antibody

Voltage-gated potassium channel subunit Kv2.2, Potassium voltage-gated channel subfamily B member 2

SwissProt ID

A6H8H5 (Mouse), Q4ZHA6 (Bovin), Q63099 (Rat), Q92953 (Human), Q95167 (Canfa), Q95L11 (Rabit)

Gene ID

9312 (KCNB2)

Available reactivities

Ms (Mouse), Rt (Rat), Xen (Xenopus), Hu (Human)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP)

Background of KCNB2 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, twopore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotidegated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Voltage gated channels are tetrameters composed of four alpha-subunits arranged around a central pore. Each alpha- subunit consists of six transmembrane segments with cytoplasmic NH2 and COOH-termini. Members of the KV1-KV4 subfamilies generate functional K+ channels in a homotetrameric configuration. The KV2 subfamily consists of KV2.1 and KV2.2, and both have very similar properties. Members of the KV2 subfamily are widely expressed in neuronal tissues. They have also been reported in neurons in the dorsal root ganglia (3-5).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNB2 antibody

Western blot of rat brain homogenate showing specific immunolabeling of the ~125k voltage-gated potassium channel, Kv2.2 (Control). The immunolabeling is blocked by preadsorption with the peptide used as antigen (Peptide Block). Rabbit IgG Aff - Purified Rt, Xen C, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNB2 antibody

immunoblot against adult rat brain membranes (RBM) and membranes from Kv2.2 wild-type (WT) and knockout (KO) mice probed with K37/89 (left) or K89/34 TC supe. Mouse brains courtesy of Amy Huntley and Jeanne Nerbonne (Washington University). Mouse IgG2a K37/89 Supernatant Hu, Ms, Rt C, ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNB2 antibody

immunoblot against adult rat brain membranes (RBM) and membranes from Kv2.2 wild-type (WT) and knockout (KO) mice probed with K37/89 (left) or K89/34 TC supe. Mouse brains courtesy of Amy Huntley and Jeanne Nerbonne (Washington University). Mouse IgG2a K37/89 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNB2 antibody

IHC analysis of Kv2.2 in frozen sections of mouse brain extract using the antibody Mouse IgG2a S37-89 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNB2 antibody

Western blot analysis of rat brain lysate: 1. Anti-Kv2.2 antibody , (1:2000). 2. Anti-Kv2.2 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNB2 antibody

Adult rat brain immunohistochemistry Mouse IgG1 N372C/51 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNB2 antibody

Immunofluorescence staining of adult wild-type (WT) and Kv2.2 knockout (KO) mouse magnocellular preoptic nucleus (MCPO) with N372B/60 (red) and Hoechst nuclear stain (blue). Mouse IgG2b N372B/60 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNB2 antibody

Immunoblot against extracts of COS cells transiently transfected with GFP-tagged Kv2.2long, Myc-tagged Kv2.2short or untagged Kv2.1 plasmid; and adult brain membranes from rat (RBM), Kv2.2 wild-type (WT) and knockout (KO) mice probed with N372B/1 (left) or N52A/42 (right) TC supe. Mouse IgG1 N372B/1 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNB2 antibody

Immunoblot against extracts of COS cells transiently transfected with GFP-tagged Kv2.2long, Myc-tagged Kv2.2short or untagged Kv2.1 plasmid; and adult brain membranes from rat (RBM), Kv2.2 wild-type (WT) and knockout (KO) mice probed with N372B/1 (left) or N52A/42 (right) TC supe. Mouse IgG1 N372B/1 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNB2 antibody

Western blot analysis using Kv2.2 antibody on rat brain lysate in the absence and presence of antigen peptide. Rabbit IgG Aff - Purified Ms, Rt, Xen C, WB
10 Blots / €460.00
  Acris Antibodies GmbH

KCNB2 antibody

Western Blot: Potassium voltage-gated channel subfamily B member 2 Antibody (S40B-18) [NBP1-44507] - Lysate of COS cells transiently-transfected with BK Beta3a plasmid and probed with NBP1-44507. Mouse IgG1 S40B-18 Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €530.00
  Novus Biologicals Inc.

KCNB2 antibody

KCNB2 Mouse IgG2 S37-89 Purified Hu, Ms, Rt C, IP, P, WB
0.1 mg / €450.00
  Novus Biologicals Inc.

12 Item(s)

per page
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