KCNC1 antibody

Principal name

KCNC1 antibody

Alternative names for KCNC1 antibody

Potassium voltage-gated channel subfamily C member 1, Voltage-gated potassium channel subunit Kv3.1, Kv4, NGK2

SwissProt ID

P15388 (Mouse), P25122 (Rat), P48547 (Human)

Gene ID

25327 (Kcnc1), 3746 (KCNC1), 16502

Available reactivities

Ms (Mouse), Rt (Rat), Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Rb (Rabbit), Ze (Zebrafish), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), Immunoprecipitation (IP), Neutralisation (NEUT), Enzyme Immunoassay (E)

Background of KCNC1 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Potassium voltage-gated channel, Shaw-related subfamily, member 1, also known as KCNC1 or Kv3.1, is a human gene. The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily (3). The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes.
Kv3.1b has been extensively tested in the auditory regions of mammals, and the decline of Kv3.1b expression appears to correlate with the functional decline in the medial olivocochlear efferent system (4). Other research shows potential for Kv3.1b channels to be oxygen sensors (5).

General readings

1. Blaine JT, Ribera AB (1998) Heteromultimeric potassium channels formed by members of the Kv2 subfamily. J. Neurosci 18:9585-9593.
2. Burger C, Ribera AB (1996) Xenopus spinal neurons express Kv2 potassium channel transcripts during embryonic development. J Neurosci 16:1412-1421.
3. Gan L, Hahn SJ, Kaczmarek LK (1999) Cell type-specific expression of the Kv3.1 gene is mediated by a negative element in the 5' untranslated region of the Kv3.1 promoter. J Neurochem 73:1350-1362.
4. Maletic-Savatic M, Lenn NJ, Trimmer JS (1995) Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro. J Neurosci 15:3840-3851.
5. Pongs O (1999) Voltage-gated potassium channels: from hyperexcitability to excitement. FEBS Lett 452:31-35.
6. von Hehn CA, Bhattacharjee A, Kaczmarek LK. Loss of Kv3.1 tonotopicity and alterations in cAMP response
element-binding protein signaling in central auditory neurons of hearing impaired mice. J Neurosci 2004;24:1936-1940.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNC1 pSer503 antibody

Figure 1. Immunohistochemistry staining of medial nucleus of the trapezoid body (MNTB) cells with the phospho-Ser503  Kv3.1 subunit antibody.
Left: Control cells. 
Right: Cells that have been exposed to the protein kinase C activator PMA. Rabbit IgG Aff - Purified Ms, Rt C, Dot, ICC/IF, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

KCNC1 antibody

Adult rat hippocampus immunohistochemistry Mouse IgG1 N16B/8 Supernatant Hu, Ms, Rt C, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNC1 antibody

Adult rat hippocampus immunohistochemistry Mouse IgG1 N16B/8 Purified Hu, Ms, Rt C, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNC1 antibody

Western blot analysis of KV3.1 in rat brain extract using a 1:1000 dilution of TA309426. Mouse IgG1 S16B-8 Purified Hu, Ms, Rt C, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNC1 antibody

Predicted band size: 58 kDa . Positive control: Mouse skeletal muscle tissue lysate. Recommended dilution: 1/200-1000 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNC1 antibody

Predicted band size: 58 kDa . Positive control: Mouse liver tissue lysate. Recommended dilution: 1/500-2000 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNC1 antibody

Western blot analysis of rat brain membranes: 1. Anti-Kv3.1b antibody , (1:200). 2. Anti-Kv3.1b antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNC1 antibody

Western Blot: Kv3.1 Antibody [TA336758] - Membrane preparations from HEK-293 cells untransfected (lane 1), transfected with Kv3.1 (lanes 2 and 4) and transfected with Kv1.2 (lane 3) were subjected to SDS-PAGE and were Western blotted with Kv3.1 Antibody ( Rabbit Purified Bov, Can, Hu, Ms, Rb, Rt IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNC1 antibody

WB Suggested Anti-KCNC1 Antibody Titration: 2.5 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNC1 antibody

Western blot analysis using Kv3.1b antibody on rat brain lysate. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €360.00
  Acris Antibodies GmbH

KCNC1 pSer503 antibody

Immunohistochemical staining of CHO cells using Kv3.1 (Ser503) antibody. Left panel shows control cells. Right panel shows cells that have been exposed to protein kinase C activator PMA. Rabbit IgG Aff - Purified Rt C
10 Blots / €460.00
  Acris Antibodies GmbH

KCNC1 antibody

KCNC1 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

KCNC1 pSer503 antibody

Immunostaining of medial nucleus of the trapezoid body (MNTB) cells with Kcnc1 (phospho S503) polyclonal antibody ( Cat # PAB9689 ). The left panel shows control cells. The right panel shows cells that have been exposed to the Kcnc1 activator PMA. Rabbit IgG Ms, Rt C, ICC/IF, WB
0.1 ml / €510.00
  Abnova Taiwan Corp.

KCNC1 antibody

Western blot analysis using Kcnc1 polyclonal antibody ( Cat # PAB10105 ) on rat brain lysate. Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

KCNC1 antibody

Human HepG2; WB Suggested Anti-KCNC1 Antibody Titration: 2.5ug/ml. Positive Control: HepG2 cell lysate; KCNC1 antibody - N-terminal region (ARP46558_T100) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rb, Rt, Ze WB
0.1 mg / €310.00
  AVIVA Systems Biology

KCNC1 antibody

Western blot analysis of Kv3.1 expression in HepG2 (A); rat brain (B) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rb, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

KCNC1 antibody

Western blot analysis of Kv3.1 expression in HepG2 (A); rat brain (B) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rb, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

KCNC1 antibody

Western blot analysis of Kv3.1 expression in HepG2 (A); rat brain (B) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rb, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

KCNC1 pSer503 antibody

CHO cells expressing recombinant Voltage Gated Potassium Channel Kv3.1. The images show immunohistochemical staining of medial nucleus of the trapezoid body (MNTB) cells with the antibody specific for phospho Ser503 in Kv3.1, the voltage gated potassium channel. The image in the left panel shows control cells. The image at the right shows cells that had been exposed to the protein kinase C activator PMA. Rabbit IgG Aff - Purified Rt C, ICC/IF, WB
0.1 ml / €380.00
  Neuromics Antibodies

KCNC1 pSer503 antibody

Immunohistochemistry: Potassium Channel, Voltage Gated, Kv3.1-Subunit Phosphospecific Antibody [NB300-279] - IHC staining of medial nucleus of the trapezoid body (MNTB) cells with the phospho-Ser503 Kv3.1 subunit antibody. The left panel shows control cells. The right panel shows cells that have been exposed to the protein kinase C activator PMA. Rabbit Aff - Purified Ms, Rt C, P, WB
0.1 ml / €380.00
  Novus Biologicals Inc.

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