KCNC4 antibody

Principal name

KCNC4 antibody

Alternative names for KCNC4 antibody

Potassium voltage-gated channel subfamily C member 4, Voltage-gated potassium channel subunit Kv3.4, KSHIIIC

SwissProt ID

Q03721 (Human), Q63734 (Rat), Q8R1C0 (Mouse)

Gene ID

3749 (KCNC4), 684516 (Kcnc4), 99738

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Can (Canine), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP)

Background of KCNC4 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Kv3.4, a member of the Shaw subfamily, may play important roles in maintaining normal function of the corneal epithelium (3). Kv3.4 is also over-expressed in the early stages of Alzheimer’s disease, and therefore represents a novel therapeutic target for this disease (4).

General readings

Mosing, M.A., et al. Twin Res Hum Genet 13(4):398-403(2010)
Menendez, S.T., et al. J. Pathol. 221(4):402-410(2010)
Leblanc, N. Cardiovasc. Res. 86(3):351-352(2010)
Miguel-Velado, E., et al. Cardiovasc. Res. 86(3):383-391(2010)
Abbott, G.W., et al. FASEB J. 20(2):293-301(2006)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNC4 (175-192) antibody

  Mouse Monoclonal Anti-Kv3.4 Antibody  
Western blot analysis of Kv3.4 in rat brain membrane lysates using a 1:1000 dilution of the antibody Mouse IgG1 S72-16 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNC4 antibody

  Rabbit polyclonal Anti-KV3.4  
Western blot analysis of rat brain membranes: 1. Anti-Kv3.4 antibody , (1:200). 2. Anti-Kv3.4 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNC4 antibody

  Rabbit Polyclonal Anti-KCNC4 Antibody  
WB Suggested Anti-KCNC4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNC4 antibody

Immunoblot against crude C. elegans worm extracts and brain membranes from adult rat (RBM) probed with N72/16 TC supe. Mouse IgG1 N72/16 Supernatant Hu, Ms, Rt C, ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNC4 antibody

Immunoblot against crude C. elegans worm extracts and brain membranes from adult rat (RBM) probed with N72/16 TC supe. Mouse IgG1 N72/16 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNC4 antibody

Immunohistochemistry (IHC) analyzes of Kv3.4 antibody (Cat.-No.: AP21098PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

KCNC4 (C-term) antibody

Western blot analysis of KCNC4 Antibody (C-term) Cat.-No AP52301PU-N in 293 cell line lysates (35ug/lane). This demonstrates the KCNC4 antibody detected the KCNC4 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

KCNC4 antibody

KCNC4 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

KCNC4 - human gene knockout kit via CRISPR

KCNC4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

KCNC4 - human gene knockout kit via CRISPR

KCNC4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNC4 - human gene knockout kit via CRISPR

KCNC4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNC4 - human gene knockout kit via CRISPR

KCNC4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnc4 - mouse gene knockout kit via CRISPR

Kcnc4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Kcnc4 - mouse gene knockout kit via CRISPR

Kcnc4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnc4 - mouse gene knockout kit via CRISPR

Kcnc4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnc4 - mouse gene knockout kit via CRISPR

Kcnc4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

KCNC4 overexpression lysate

KCNC4 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

KCNC4 overexpression lysate

KCNC4 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KCNC4 (mGFP-tagged) - Human potassium voltage-gated channel, Shaw-related subfamily, member 4 (KCNC4), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNC4 (mGFP-tagged) - Human potassium voltage-gated channel, Shaw-related subfamily, member 4 (KCNC4), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,290.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNC4 (mGFP-tagged)-Human potassium voltage-gated channel, Shaw-related subfamily, member 4 (KCNC4), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNC4 (mGFP-tagged)-Human potassium voltage-gated channel, Shaw-related subfamily, member 4 (KCNC4), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,280.00
  OriGene Technologies, Inc.

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