KCND1 antibody

Principal name

KCND1 antibody

Alternative names for KCND1 antibody

Voltage-gated potassium channel subunit Kv4.1, Potassium voltage-gated channel subfamily D member 1

SwissProt ID

P59994 (Rabit), Q03719 (Mouse), Q52PG9 (Bovin), Q9NSA2 (Human)

Gene ID

3750 (KCND1), 16506 (Kcnd1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of KCND1 antibody

Kv4.1 is a voltage-dependent K+ channel that belongs to the Shal channel subfamily and includes two other members: Kv4.2 and Kv4.3. Kv4.1 possesses the sigture structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. As with other members of the voltage-gated K+ channel superfamily, the functiol channel is a tetramer that can be composed of more than one member of the Shal subfamily, i.e. heterotetramers of Kv4.1 and Kv4.2. The Kv4 channels are characterized by activation at subthreshold membrane potentials, ictivate rapidly and recover from ictivation quickly compared with other voltage-dependent K+ channels. This type of current is known as transient A-type K+ currents. For example, depolarization-activated K+ currents in rat neostriatal cholinergic interneurons are predomintly of the A-type and attributable to coexpression of Kv4.1 and Kv4.2 subunits. The biophysical properties of the Kv4.1 subunit can be modified by its association with auxiliary b subunits such as KChIP1 that increase Kv4.1 current densities and accelerates both the ictivation and the recovery time. Kv4.1 is highly expressed in brain but is also expressed in peripheral tissues such as colon, heart and lung. The pharmacology of Kv4.1 has been less well studied than that of the other Kv4 members. Kv4.1 is sensitive to the classical K+ channel blockers, 4-aminopyridine and tetraethylammonium. Recently HmTx1 a peptide blocker derived from the venom of the African tarantula Heteroscodra maculata has been shown to be a potent inhibitor of Kv4.1.

General readings

Jang, S.H., et al. Biochem. Biophys. Res. Commun. 384(2):180-186(2009)
Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)
Jerng, H.H., et al. Biophys. J. 87(4):2380-2396(2004)
Nakamura, T.Y., et al. FEBS Lett. 499(3):205-209(2001)
Isbrandt, D., et al. Genomics 64(2):144-154(2000)

12 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCND1 antibody

  Rabbit polyclonal anti-KCND1 antibody  
Western blot analysis of extracts from 3T3 cells, using KCND1antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCND1 antibody

  Rabbit Polyclonal Anti-KV4.1  
Western blot analysis of rat brain lysate: 1. Anti-KV4.1 antibody, (1:400). 2. Anti- KV4.1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCND1 antibody

  Rabbit Polyclonal Anti-Kcnd1 Antibody  
WB Suggested Anti-Kcnd1 Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse Spleen Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCND1 antibody

  Rabbit Polyclonal Anti-KCND1 Antibody  
Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane: Human fetal liver tissue, Primary antibody: (KCND1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCND1 (N-term) antibody

Western blot analysis of KCND1 Antibody (N-term) Cat.-No AP52302PU-N in 293 cell line lysates (35ug/lane). This demonstrates the KCND1 antibody detected the KCND1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

KCND1 antibody

Western blot analysis of extracts from NIH-3T3 cells, using KCND1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €230.00
  Assay Biotech

KCND1 antibody

Western blot analysis of extracts from NIH-3T3 cells, using KCND1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

Kcnd1 - mouse gene knockout kit via CRISPR

Kcnd1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Kcnd1 - mouse gene knockout kit via CRISPR

Kcnd1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

KCND1 overexpression lysate

KCND1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KCND1 (mGFP-tagged) - Human potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), 200 uL, >10^7 TU/mL

Lenti ORF particles, KCND1 (mGFP-tagged) - Human potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCND1 (Myc-DDK tagged) - Human potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, KCND1 (Myc-DDK tagged) - Human potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

12 Item(s)

per page
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