KCND2 antibody

Principal name

KCND2 antibody

Alternative names for KCND2 antibody

Potassium voltage-gated channel subfamily D member 2, Voltage-gated potassium channel subunit Kv4.2, KIAA1044

SwissProt ID

P59995 (Rabit), Q63881 (Rat), Q9NZV8 (Human), Q9Z0V2 (Mouse)

Gene ID

3751 (KCND2), 65180 (Kcnd2), 3751337 (IPR003180), 16508

Available reactivities

Ft (Ferret), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Chk (Chicken), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E)

Background of KCND2 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels. The Kv4.2 potassium channel is a voltage-gated channel protein which belongs to the delayed rectifier class and to the ShaI potassium channel subfamily. All of the KV channels can product delayed-rectifier and transient “A-type” currents, all members of the KV4 subfamily mediate IA. Kv4 channels in the central nervous system localize to the soma and dendrites, and therefore are responsible for the somato-dendritic A-type K+ current (ISA).

General readings

Foeger, N.C., et al. J. Biol. Chem. 285(43):33413-33422(2010)
Levy, D.I., et al. J. Physiol. (Lond.) 588 (PT 14), 2657-2668 (2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010)
Aronica, E., et al. Neurobiol. Dis. 36(1):81-95(2009)
Tayo, B.O., et al. Circ Cardiovasc Genet 2(1):38-45(2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCND2 antibody

adult rat brain immunohistochemistry Mouse IgG1 K57/1 Supernatant Ms, Rt C, ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCND2 antibody

adult rat brain immunohistochemistry Mouse IgG1 K57/1 Purified Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCND2 antibody

Western blot analysis on rat brain membrane tissues using a 1:1000 dilution of the antibody Mouse IgG1 S57-1 Purified Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCND2 antibody

Western blot analysis of rat brain membranes: 1. Anti-KV4.2 antibody , (1:200). 2. Anti-KV4.2 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCND2 antibody

WB Suggested Anti-KCND2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human heart Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCND2 antibody

Immunoblot against crude brain membranes from adult rat (RBM) and wild-type (WT) and Kv4.2 knockout (KO) mice probed with L28/4 (left) or N52A/42 (right) TC supe. Mouse IgG1 L28/4 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCND2 antibody

Immunoblot against crude brain membranes from adult rat (RBM) and wild-type (WT) and Kv4.2 knockout (KO) mice probed with L28/4 (left) or N52A/42 (right) TC supe. Mouse IgG1 L28/4 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCND2 (209-225) antibody

Immunohistochemistry analysis of Kv4.2 using KCND2 antibody Cat.-No AM20100PU, mouse cerebellum. Strong membrane positivity of neurons and fibers of cerebellum. White matter clearly negative. Mouse IgG1 S57-1 Purified Ms, Rt C, ICC/IF, IP, P, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

KCND2 antibody

KCND2 Rabbit IgG Purified Rt WB
0.1 mg / €360.00
  Acris Antibodies GmbH

KCND2 antibody

Western blot analysis using Kv4.2 antibody on rat brain lysate. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €360.00
  Acris Antibodies GmbH

KCND2 (N-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue reacted with  KCND2 Antibody (N-term) Cat.-No AP52303PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

KCND2 antibody

KCND2 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

KCND2 antibody

KCND2 Rabbit Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

KCND2 antibody

Western blot analysis using Kcnd2 polyclonal antibody ( Cat # PAB10107 ) on rat brain lysate. Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

KCND2 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Kv4.2/KCND2 (Ab-616) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
50 µg / €205.00
  Assay Biotech

KCND2 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Kv4.2/KCND2 (Ab-616) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €310.00
  Assay Biotech

KCND2 antibody

Human Heart; WB Suggested Anti-KCND2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Human heart; KCND2 antibody - middle region (ARP35211_P050) in Human Heart cells using Western Blot Rabbit Aff - Purified Chk, Hu, Ms, Rb, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

KCND2 antibody

KCND2 Rabbit IgG Aff - Purified Ms
0.1 mg / €680.00
  Funakoshi Co., Ltd.

KCND2 antibody

KCND2 Rabbit IgG Aff - Purified Ms WB
50 µg / €680.00
  Funakoshi Co., Ltd.

KCND2 (209-225) antibody

Adult WT and Kv4.2-/- mouse double immunofluorescence staining anti-Kv4.2 (red) and rabbit polyclonal anti-Kv2.1 (green). Mouse IgG1 K57/1 Aff - Purified Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €440.00
  Neuromics Antibodies

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