KCNE2 antibody

Principal name

KCNE2 antibody

Alternative names for KCNE2 antibody

KCNE2, Potassium channel subunit beta MiRP1, MinK-related peptide 1, Potassium voltage-gated channel subfamily E member 2, Minimum potassium ion channel-related peptide 1

SwissProt ID

P63161 (Rat), Q9BDR0 (Rabit), Q9D808 (Mouse), Q9Y6J6 (Human)

Gene ID

9992 (KCNE2), 171138 (Kcne2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of KCNE2 antibody

KCNE2 (or MiRP1) is a member of a family of proteins that regulate the activity of voltage-dependent K+ channels. The other members of the family are KCNE1 (IsK, MiNK), KCNE3 (MiRP2), KCNE4 (MiRP3) and KCNE5 (MiRP4). KCNE1 is the founding member of the family and KCNE2 was discovered based on its homology with KCNE1. The KCNE regulatory subunits are small proteins (14- 20 kD) with a type-1 integral membrane topology. It is believed that both the cytoplasmic C-terminus tail and the transmembrane domain are necessary for the interaction with the a subunits. The stoichiometry of the KCNE subunits with their partner a subunits in the tive channels is not clear and ratios ranging from 2 to 14 KCNE subunits per 4 a subunits have been proposed. KCNE2 is broadly distributed with prominent expression in brain and heart, but also in other tissues such as skeletal muscle, pancreas and kidney. The best described functiol association of KCNE2 is with the voltage-gated K+ channel Kv11.1 (HERG). In the heart, complexes of the two proteins constitute the molecular underlay of the cardiac IKr current and mutations in the KCNE2 subunit are associated with cardiac arrhythmias.KCNE2 can form complexes with other channels including the K+ channels Kv7.1 (KCNQ1) and Kv4.3 and the hyperpolarization-activated cation channels HCN1 and HCN2. In the stomach Kv7.1/KCNE2 complexes were found to be crucial for acid secretion as well as for the maintence of structural integrity, and for parietal cell survival.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNE2 antibody

Western blot analysis of rat heart membranes: 1. Anti-KCNE2 (MiRP1) antibody , (1:200). 2. Anti-KCNE2 (MiRP1) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNE2 antibody

KCNE2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

KCNE2 antibody

KCNE2 Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

KCNE2 antibody

KCNE2 Rabbit Hu C, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KCNE2

KCNE2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

KCNE2

KCNE2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

KCNE2

KCNE2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

KCNE2

KCNE2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

KCNE2

KCNE2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

KCNE2 overexpression lysate

KCNE2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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