KCNE3 antibody

Principal name

KCNE3 antibody

Alternative names for KCNE3 antibody

KCNE3, Potassium channel subunit beta MiRP2, MinK-related peptide 2, Potassium voltage-gated channel subfamily E member 3, Minimum potassium ion channel-related peptide 2

SwissProt ID

Q9JJV7 (Rat), Q9WTW2 (Mouse), Q9Y6H6 (Human)

Gene ID

10008 (KCNE3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Hst (Hamster), Mky (Monkey), Gorilla, Chk (Chicken), Eq (Equine), Rb (Rabbit), Xen (Xenopus)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of KCNE3 antibody

KCNE3 (or MiRP2) is a member of a family of proteins that regulate the activity of voltage-dependent K+ channels. The other members of the family are KCNE1 (IsK, MiNK), KCNE2 (MiRP1), KCNE4 (MiRP3) and KCNE5 (MiRP4). KCNE1 is the founding member of the family and was initially believed to form a K+ channel itself, but was latter recognized that it worked as a regulatory b subunit associated with the Kv7.1 (KCNQ1) a protein. KCNE3 was discovered based on its homology with KCNE1. The KCNE regulatory subunits are small proteins (14- 20 kD) with a type-1 integral membrane topology. It is believed that both the cytoplasmic C-terminus tail and the transmembrane domain are necessary for the interaction with the a subunits. The stoichiometry of the KCNE subunits with their partner a subunits in the tive channels is not clear and ratios ranging from 2 to 14 KCNE subunits per 4 a subunits have been proposed. KCNE3 is relatively widely expressed in several tissues with prominent expression in the kidney and skeletal muscle. KCNE3 is quite promiscuous and associations with Kv7.1, Kv3.4, Kv7.4 (KCNQ4), Kv11.1 (HERG), Kv2.1 and Kv3.1b have been demonstrated. The best characterized interactions are with the former two proteins. KCNE3 interacts with Kv7.1 in epithelial cells of the gastrointestil tract where it appears to be important for + absorption. In skeletal muscle KCNE3 couples to Kv3.4 to regulate muscle function. Indeed, a mutation in KCNE3 (R83H) has been associated with an inherited form of periodic paralysis (Thyrotoxic hypokalemic periodic paralysis).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNE3 antibody

Anti-KCNE3 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Gorilla, Hst, Hu, Mky
50 µg / €345.00
  OriGene Technologies, Inc.

KCNE3 antibody

Anti-KCNE3 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Bov, Can, Chk, Eq, Gorilla, Hst, Hu, Mky, Ms, Por, Rb, Rt, Xen
50 µg / €345.00
  OriGene Technologies, Inc.

KCNE3 antibody

Western blot analysis of rat kidney (lanes 1 and 3) and rat heart (lanes 2 and 4) membranes: 1, 2. Anti-KCNE3 (MiRP2) antibody, (1:200). 3, 4. Anti-KCNE3 (MiRP2) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNE3 antibody

KCNE3 Rabbit Hu, Ms, Rt C, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

KCNE3 antibody

Immunohistochemistry-Paraffin: KCNE3 Antibody [NBP1-83238] - Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in granular pattern in tubular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

5 Item(s)

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