KCNE4 antibody

Principal name

KCNE4 antibody

Alternative names for KCNE4 antibody

KCNE4, Potassium channel subunit beta MiRP3, MinK-related peptide 3, Potassium voltage-gated channel subfamily E member 4, Minimum potassium ion channel-related peptide 3

SwissProt ID

Q8WWG9 (Human), Q9WTW3 (Mouse)

Gene ID

23704 (KCNE4), 57814 (Kcne4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of KCNE4 antibody

The K+ voltage-gated channel subfamily E member (KCNE) family is a group of small, non-conducting, single transmembrane domain proteins that associate with pore-forming potassium channel subunits to form mixed complexes with unique characteristics.Five different KCNE proteins have been described (KCNE1-5)2. The KCNE regulatory subunits are small proteins (14-20 kD) with a type-1 integral membrane topology. It is believed that both the cytoplasmic C-terminus tail and the transmembrane domain are necessary for the interaction with the a subunits. MinK-related peptides (MiRPs) MiRP3, protein encoded by KCNE43. The importance of these proteins to normal physiology of the heart and nervous system is exposed by their association with clinical disorders such as congenital long QT syndrome, drug-induced cardiac arrhythmias, sensorineural deafness, and periodic paralysis. In addition, MiRPs influence the normal physiology of endocrine and exocrine glands, intestil secretion, and rel excretion. MiRP3 is found to co-localize with KV4.2 subunits that contribute to cardiac transient outward K+ currents. Levels of the KCNE4 transcript in human cardiac ventricle are robust and increase in patients with congestive failure suggesting a regulatory function for MiRP3 in the heart6. In addition to regulating KV4.2, MiRP3 also regulates KCNQ1 and BK channels.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNE4 antibody

Western blot analysis of rat pancreas membranes (lanes 1 and 3) and rat heart lysate (lanes 2 and 4): 1-2. Anti-KCNE4 (MiRP3) antibody , (1:600). 3-4. Anti-KCNE4 (MiRP3) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNE4 antibody

KCNE4 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

KCNE4 antibody

Detection limit for recombinant GST tagged KCNE4 is approximately 0.1ng/ml as a capture antibody. Mouse IgG1 1D7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

KCNE4 antibody

Immunohistochemistry-Paraffin: KCNE4 Antibody [NBP1-81049] Immunohistochemical staining of human kidney shows moderate cytoplasmic positivity in cells in tubules. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KCNE4

KCNE4 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

KCNE4

KCNE4 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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