KCNH2 antibody

Principal name

KCNH2 antibody

Alternative names for KCNH2 antibody

KCNH2, ERG, ERG1, HERG, HERG1, H-ERG, Ether-a-go-go-related protein 1, Eag-related protein 1, eag homolog, Potassium voltage-gated channel subfamily H member 2, Voltage-gated potassium channel subunit Kv11.1, Ether-a-go-go-related gene potassium channel 1

SwissProt ID

O08703, O08962, O35219, Q12809 (Human), Q8WNY2, Q9PT84, Q9TSZ3

Gene ID

3757 (KCNH2), 16511 (Kcnh2), 117018

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Rb (Rabbit), Rt (Rat), Eq (Equine), GP (Guinea Pig), Mky (Monkey), Gorilla, Bov (Bovine), Hst (Hamster), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E)

Background of KCNH2 antibody

The KV11.1 (HERG) channel is a member of the ether-a-go-go (EAG) subfamily of voltage-dependent K+ channels that includes the related proteins KV11.2 and KV11.3 (erg2 and erg3). KV11.1 possess the sigture structure of the voltage-dependent K+ channels: six membrane-spanning domains and intracellular N and C termini. The KV11.1 current is characterized by strong inward rectification with slow activation and very rapid ictivation kinetics. The channel is expressed in the brain and heart (where it underlies the IKr current) and has a central role in mediating repolarization of action potentials. Mutations in the KV11.1 channel cause inherited long QT syndrome (LQTS) or abnormalities in the repolarization of the heart that are associated with life-threatening arrhythmias and sudden death. All the identified KV11.1 mutations produce loss of function of the channel via several cellular mechanisms ranging from alterations of gating properties, alterations of channel permeability/selectivity and alterations in intracellular channel trafficking that decreases the number of channels that reach the cell membrane. Lately drug-induced forms of LQTS have been reported for a wide range of non-cardiac drugs including antIHCistamines, psychoactive agents and antimicrobials. All these drugs potently block the KV11.1 channel as an unintended side effect, prompting regulatory drug agencies to issue recommendations for the testing of new drugs for their potential KV11.1 blocking effect. In addition, KV11.1 expression was found to be upregulated in several tumor cell lines of different histogenesis suggesting that it confers the cells some advantage in cell proliferation. Indeed, in several studies it has been shown that inhibition of the KV11.1 current leads to a decrease in tumor cell proliferation. Several toxins from scorpion venoms are potent blockers (affecting the channels in the nomolar range) of KV11.1channels. Among these the most potent and selective are Ergtoxin-1, (16 nM) and BeKM-1 , (3 nM). In addition, the methanesulfonilide class III antiarrhythmic agent E-4031, also blocks KV11.1 channel in the nomolar range (7.7 nM).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNH2 antibody

  Rabbit Polyclonal Anti-KV11.1 (HERG) (extracellular)  
Western blot analysis of Kv11.1 transfected HEK-293 cells: 1. Anti-Kv11.1 (HERG) (extracellular) antibody, (1:200). 2. Anti-Kv11.1 (HERG) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNH2 antibody

  KCNH2 / HERG Rabbit Polyclonal (Internal) Antibody  
Anti-KCNH2 / Kv11.1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Eq, Gorilla, GP, Hu, Mky, Ms, Rb, Rt
50 µg / €400.00
  OriGene Technologies, Inc.

KCNH2 antibody

  KCNH2 / HERG Rabbit Polyclonal (Internal) Antibody  
Anti-KCNH2 / Kv11.1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Bov, Can, Eq, GP, Hst, Hu, Mky, Ms, Por, Rb, Rt
50 µg / €400.00
  OriGene Technologies, Inc.

KCNH2 antibody

  Anti-KCNH2 Rabbit Polyclonal Antibody  
Predicted band size: 90 kDa . Positive control: Mouse brain tissue lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 30 ug Primary antibody: 1/100 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 5 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNH2 antibody

  Rabbit anti-KCNH2 Polyclonal Antibody  
Western blot analysis of extracts of Mouse brain tissue lysate, using KCNH2 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNH2 antibody

  Rabbit Polyclonal Anti-hKV11.1 (HERG)  
Western blot analysis of Kv11.1 expressing HEK-293 cells: 1. Anti-hKv11.1 (HERG) antibody, (1:400). 2. Anti-hKv11.1 (HERG) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNH2 antibody

  Rabbit polyclonal Anti-KV11.1 (erg1)  
Western blot analysis of HEK 293 cell lysate, stably expressing HERG channels: 1. Anti-Kv11.1 (erg1) antibody (1:200). 2. Anti-Kv11.1 (erg1) antibody, preincubated with the control antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNH2 antibody

  Rabbit Polyclonal Anti-KCNH2 Antibody  
WB Suggested Anti-KCNH2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: OVCAR-3 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNH2 antibody

KCNH2 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

KCNH2 antibody

KCNH2 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

KCNH2 antibody

Western blot analysis of KCNH2 Antibody (Center) (AP18083PU-N) in CEM cell line lysates (35ug/lane).KCNH2 (arrow) was detected using the purified Pab. Rabbit Hu WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

KCNH2 - human gene knockout kit via CRISPR

KCNH2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNH2 - human gene knockout kit via CRISPR

KCNH2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KCNH2 (mGFP-tagged) - Human potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNH2 (mGFP-tagged) - Human potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,290.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNH2 (mGFP-tagged)-Human potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNH2 (mGFP-tagged)-Human potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,870.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNH2 (mGFP-tagged)-Human potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNH2 (mGFP-tagged)-Human potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,760.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNH2 (Myc-DDK tagged) - Human potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNH2 (Myc-DDK tagged) - Human potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €2,070.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNH2 (Myc-DDK-tagged)-Human potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNH2 (Myc-DDK-tagged)-Human potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,680.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNH2 (Myc-DDK-tagged)-Human potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNH2 (Myc-DDK-tagged)-Human potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,580.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Kcnh2 (GFP-tagged) - Mouse potassium voltage-gated channel, subfamily H (eag-related), member 2 (Kcnh2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnh2 (GFP-tagged) - Mouse potassium voltage-gated channel, subfamily H (eag-related), member 2 (Kcnh2), 200 uL, >10^7 TU/mL  
200 µl / €2,000.00
  OriGene Technologies, Inc.

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