KCNH4 antibody

Principal name

KCNH4 antibody

Alternative names for KCNH4 antibody

KCNH4, ELK channel 1, ELK1, Brain-specific eag-like channel 2, BEC2, Voltage-gated potassium channel subunit Kv12.3, Ether-a-go-go-like potassium channel 1, Potassium voltage-gated channel subfamily H member 4

SwissProt ID

Q9R1T9 (Rat), Q9UQ05 (Human)

Gene ID

23415 (KCNH4), 114032 (Kcnh4)

Available reactivities

Hu (Human), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Flow Cytometry (F), Western blot / Immunoblot (WB)

Background of KCNH4 antibody

Kv12.3 (also known as elk3 and KCNH4) is a voltage-gated K+ channel that belongs to the ether-a-go-go (EAG) family. The EAG family of voltage-gated K+ channels can be subdivided into three distinct groups based on sequence homology. These are the eag (Kv10) with two members, the eag-related channels (erg or Kv11) and the eag-like K+ channels (elk or Kv12) with three members each.As all members of the family, Kv12.3 possesses the sigture structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. As with all voltage-dependent K+ channels the functiol channel is a tetramer composed of four subunits. It has been suggested that the Kv12 subfamily members can form functiol heteromultimers within the subfamily.Kv12.3 channel distribution appears to be mainly confined to the central nervous system with some expression in peripheral organs such as testis and lung. The physiological function of the Kv12.3 channel hasnâ??t been established, although a role in the modulation of overall excitability of neurons has been suggested. At the moment there isnâ??t much pharmacological data concerning the modulation of the Kv12.3 channel except for blocking of the channel by Ba2+.

General readings

Bailey, S.D., et al. Diabetes Care (2010) In press
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)
Zou, A., et al. Am. J. Physiol., Cell Physiol. 285 (6), C1356-C1366 (2003)
Miyake, A., et al. J. Biol. Chem. 274(35):25018-25025(1999)

4 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNH4 antibody

Western blot analysis of rat brain (lanes 1 and 3) and cerebellum (lanes 2 and 4) lysates: 1, 2. Anti-KV12.3 (Elk3) antibody , (1:200). 3, 4. Anti-KV12.3 (Elk3) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNH4 (N-term) antibody

Western blot analysis of KCNH4 Antibody (N-term) Cat.-No AP52304PU-N in K562 cell line lysates (35ug/lane). This demonstrates the KCNH4 antibody detected the KCNH4 protein (arrow). Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

KCNH4 antibody

KCNH4 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.


Catalog No.    

KCNH4 overexpression lysate

KCNH4 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

4 Item(s)

per page
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