KCNIP1 / VABP antibody

Principal name

KCNIP1 / VABP antibody

Alternative names for KCNIP1 / VABP antibody

KCHIP1, Kv channel-interacting protein 1, A-type potassium channel modulatory protein 1, Potassium channel-interacting protein 1, Vesicle APC-binding protein

SwissProt ID

Q8R426 (Rat), Q9JJ57 (Mouse), Q9NZI2 (Human)

Gene ID

30820 (KCNIP1), 30819 (KCNIP2), 65023 (Kcnip1), 70357

Available reactivities

Bov (Bovine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), African clawed frog

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Flow Cytometry (F), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of KCNIP1 / VABP antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
There are four member of the KChiPs (Kv4 potassium channel interacting protein) family. They are all EF handcontaining proteins required for the raffic of channelforming Kv4 K+ subunits to the plasma membrane (3). KChiP1 is expressed predominantly in the brain, with relative abundance in Purkinje cells of the cerebellum, the reticular neuclei, the medial habenular nuclei, the hippocampus and the striatum (4). It is expressed in a subpopulation of parvalbumin-positve neurons, suggesting its functional relationship with the GABAergic inhibitory neurons (4).

General readings

1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA.
2. Flowerdew S.E., and Burgoyne R.D. (2009) Biochem J. 418(3): 529-540.
3. Xiong H., Xia K., Li B., Zhao G., and Zhang Z. (2009)
Acta Biochim Biophys Sin. 41(4): 295-300.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNIP1 / VABP antibody

IHC analysis of KChIP1 in frozen sections of mouse brain extract using the antibody Mouse IgG1 S55-7 Purified Hu, Ms, Rt C, ICC/IF
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNIP1 / VABP antibody

Western blot analysis on rat brain membrane tissues using a 1:1000 dilution of the antibody Mouse IgG2a S55-82 Purified Hu, Ms, Rt C, ICC/IF
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNIP1 / VABP antibody

Western blot analysis of rat brain lysate: 1. Anti-KChIP1 antibody , (1:200). 2. Anti-KChIP1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNIP1 / VABP antibody

Western Blot: VABP Antibody (6C239.4) [TA337076] - Analysis of VABP in 1) transfected 293T cells from Abnova and 2) untransfected 293T cells using TA337076 at 2 ug/ml. Mouse IgG1 6C239.4 Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNIP1 / VABP antibody

adult rat hippocampus immunohistochemistry Mouse IgG1 K55/7 Supernatant Hu, Ms, Rt C, ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNIP1 / VABP antibody

adult rat hippocampus immunohistochemistry Mouse IgG1 K55/7 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNIP1 / VABP (1-216) antibody

KCNIP1 / VABP Mouse IgG1 S55-7 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

KCNIP1 / VABP (12-22) antibody

Western blot analysis of extracts from mouse brain using anti-kchip1 rabbit whole antiserum. Rabbit Azide Free Ms E, WB
0.5 mg / €680.00
  Acris Antibodies GmbH

KCNIP1 / VABP (12-22) antibody

Western blot analysis of extracts from mouse brain using anti-kchip1 rabbit whole antiserum. Rabbit Azide Free Ms E, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

KCNIP1 / VABP antibody

Western Blot analysis of KCNIP1 expression in transfected 293T cell line (H00030820-T01) by KCNIP1 MaxPab polyclonal antibody.

Lane 1: KCNIP1 transfected lysate(23.87 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

KCNIP1 / VABP antibody

KCNIP1 / VABP Mouse IgG2a 3D9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

KCNIP1 / VABP antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using KCIP1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

KCNIP1 / VABP antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using KCIP1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €310.00
  Assay Biotech

KCNIP1 / VABP antibody

Human Brain; KCNIP1 antibody - N-terminal region (ARP35246_T100) in Human Brain cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Chk, Hu, Ms, Por, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

KCNIP1 / VABP (1-216) antibody

KChIP1 staining of adult rat hippocampus. Mouse IgG1 Aff - Purified Hu, Ms, Rt C, ICC/IF, IP
0.1 ml / €440.00
  Neuromics Antibodies

KCNIP1 / VABP antibody

KCNIP1 / VABP Mouse IgG1 S55-7 Purified Hu, Ms, Rt C, IP, P
0.1 mg / €450.00
  Novus Biologicals Inc.

KCNIP1 / VABP antibody

KCNIP1 / VABP Mouse IgG2a S55-82 Purified Hu, Ms, Rt IP, P, WB
0.1 mg / €450.00
  Novus Biologicals Inc.

KCNIP1 / VABP antibody

Immunohistochemistry-Paraffin: KCNIP1 Antibody [NBP1-81560] - Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells of tubules. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Pan KChIP / KCNIP antibody

immunoblot versus crude brain membranes from adult mouse (MBM), rat (RBM) and human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)] probed with K55/82 (left) and N52A/42 (right) TC supe. Mouse IgG2a K55/82 Supernatant Hu, Ms, Rt C, ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

Pan KChIP / KCNIP antibody

immunoblot versus crude brain membranes from adult mouse (MBM), rat (RBM) and human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)] probed with K55/82 (left) and N52A/42 (right) TC supe. Mouse IgG2a K55/82 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

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