KCNIP2 antibody

Principal name

KCNIP2 antibody

Alternative names for KCNIP2 antibody

KCNIP2, KCHIP2, Kv channel-interacting protein 2, A-type potassium channel modulatory protein 2, Potassium channel-interacting protein 2, Cardiac voltage-gated potassium channel modulatory subunit

SwissProt ID

Q8WN03 (Muspf), Q9JJ69 (Mouse), Q9JM59 (Rat), Q9NS61 (Human), Q9NS61-6

Gene ID

30819 (KCNIP2), 56817 (Kcnip2)

Available reactivities

Rb (Rabbit), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP)

Background of KCNIP2 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels.
There are four member of the KChiPs (Kv4 potassium channel interacting protein) family. They are all EF handcontaining proteins required for the traffic of channelforming Kv4 K+ subunits to the plasma membrane. KChiP2 expression has been found to be significantly decreased in hypertrophy and heart failure, and does so thru modulatin of intracellular concentration and calcineurin/NFAT pathways. It has also been found that KChiP2 also functionally modulates the Cav1.2 goverened Ltype calcium channel through a direct interaction between KChiP2 and the amino-terminus of Cav1.2.

General readings

General / background references:Jo DG et al. Pro-apoptotic function of calsenilin/DREAM/KChIP3. FASEB J 15:589-91 (2001). PubMed PMID: 11259376
Rosati B et al. Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. J Physiol 533:119-25 (2001). PubMed PMID: 11351020
An WF et al. Modulation of A-type potassium channels by a family of calcium sensors. Nature 403:553-6 (2000). PubMed PMID: 10676964

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNIP2 antibody

Lanes: ; Lane 1: 20ug HEK-293 cell lysate; Lane 2: 20ug mkchIP2-YFP transfected HEK-293 lysate; Lane 3: 20ug mkchIP3-YFP transfected HEK-293 lysate; Lane 4: 20ug mkchIP4-YFP transfected HEK-293 lysate; Primary Antibody Dilution: ; 1:1000; Secondary Antibo Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNIP2 antibody

Human Jurkat; Host:Rabbit. Target Name:KCNIP2. Sample Tissue:Human Jurkat. Antibody Dilution: 1.0ug/ml. KCNIP2 is supported by BioGPS gene expression data to be expressed in Jurkat.; KCNIP2 antibody - N-terminal region (ARP35491_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

KCNIP2 antibody

Western blot analysis on rat brain membrane tissues using a 1:1000 dilution of the antibody Mouse IgG1 S60-73 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNIP2 antibody

WB Suggested Anti-KCNIP2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Hela cell lysate Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNIP2 antibody

WB Suggested Anti-KCNIP2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Jurkat cell lysate KCNIP2 is supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNIP2 antibody

WB Suggested Anti-KCNIP2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Stomach Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNIP2 antibody

WB Suggested Anti-KCNIP2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: 721_B cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNIP2 antibody

WB Suggested Anti-KCNIP2 Antibody Titration: 0.06 ug/ml; ELISA Titer: 1:62500; Positive Control: Jurkat cell lysate KCNIP2 is supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNIP2 antibody

WB Suggested Anti-KCNIP2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Liver Rabbit IgG Purified Can, Hu, Rb WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNIP2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KCNIP2 (RC203823, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-KCNIP2. Mouse IgG1 OTI3C4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

KCNIP2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KCNIP2 (RC203823, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-KCNIP2. Mouse IgG1 OTI2D2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

KCNIP2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KCNIP2 (RC203823, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-KCNIP2. Mouse IgG1 OTI2G8 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

KCNIP2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KCNIP2 (RC203823, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-KCNIP2. Mouse IgG1 OTI3D8 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

KCNIP2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KCNIP2 (RC203823, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-KCNIP2. Mouse IgG1 OTI10H1 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

KCNIP2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KCNIP2 (RC203823, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-KCNIP2. Mouse IgG2b OTI14A7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

KCNIP2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KCNIP2 (RC203823, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-KCNIP2. Mouse IgG1 OTI10F10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

KCNIP2 antibody

Adult rat brain membrane immunoblot Mouse IgG1 K60/73 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNIP2 antibody

Adult rat brain membrane immunoblot Mouse IgG1 K60/73 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNIP2 (1-252) antibody

KCNIP2 Mouse IgG1 S60-73 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

KCNIP2 antibody

KCNIP2 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

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