KCNJ1 antibody

Principal name

KCNJ1 antibody

Alternative names for KCNJ1 antibody

KCNJ1, ROMK1, ATP-regulated potassium channel ROM-K, Kir1.1, ATP-sensitive inward rectifier potassium channel 1, Potassium channel, inwardly rectifying subfamily J member 1

SwissProt ID

O88335 (Mouse), P35560 (Rat), P48048 (Human), P52192 (Caeel)

Gene ID

3758 (KCNJ1), 24521 (Kcnj1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Ze (Zebrafish), African clawed frog, Bov (Bovine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of KCNJ1 antibody

Kir1.1 (ROMK1) was the first member of the family of inward rectifying K+ channels to be cloned. The family includes 15 members that are structurally and functiolly different from the voltage-dependent K+ channels.The familyâ??s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functiol unit for the Kir channels is composed of four subunits that can assembly as either homo or heterotetramers.Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis.As its origil me indicates (ROMK1 stands for Rel Outer Medullary K+ channel) Kir1.1 is strongly expressed in the kidney in the apical membrane of several kidney segments such as the thick ascending loop of Henle (TAL) and the cortical collecting duct (CCD). In addition, the channel is also expressed in the brain mainly in the cortex and hippocampus.Kir1.1 plays a key role in K+ recycling in the loop of Henle. Indeed, loss of function mutations in the Kir1.1 gene cause Bartterâ??s syndrome type II, a recessive autosomal disease characterized by the impairment of K+ efflux and the subsequent ibility of the NKCC2 transporter to continue Cl uptake. This leads to a high salt concentration in the urine that induces osmotic diuresis and low plasma volume.Pharmacologically, the Kir1.1 channel can be inhibited by several general K+ channel blockers such as Tertiapin (#STT-250), however the scorpion toxin Lq2 (#RTL-550) specifically and potently inhibits Kir1.1 channels.

General readings

Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon DB, Newton-Cheh C, State MW, Levy D, Lifton RP.
Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat. Genet. 2008 May 40 (5): 592-9. PMID: 18391953

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNJ1 antibody

TA305615 (1ug/ml) staining of Human Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNJ1 antibody

Western blot analysis of rat kidney membranes: 1. Anti-Kir1.1 (ROMK1) antibody , (1:200). 2. Anti-Kir1.1 (ROMK1) antibody, preincubated with the control antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNJ1 antibody

Lanes: ; Lane 1: 30ug mouse renal epithelial lysate; Lane 2: 30ug mouse renal epithelial lysate; Lane 3: 30ug mouse renal epithelial lysate; Primary Antibody Dilution: ; 1:500; Secondary Antibody: ; Anti-rabbit-HRP; Secondary Antibody Dilution: ; 1:2500; Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNJ1 antibody

KCNJ1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

KCNJ1 pSer44/25 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using ROMK/Kir1.1 (Phospho-Ser44/25) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

KCNJ1 pSer44/25 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using ROMK/Kir1.1 (Phospho-Ser44/25) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €310.00
  Assay Biotech

KCNJ1 antibody

Immunofluorescence analysis of A549 cells, using ROMK/Kir1.1 (Ab-44/25) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
50 µg / €205.00
  Assay Biotech

KCNJ1 antibody

Immunofluorescence analysis of A549 cells, using ROMK/Kir1.1 (Ab-44/25) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
0.1 mg / €310.00
  Assay Biotech

KCNJ1 antibody

Mouse renal epithelial; . Lanes: Lane 1: 30ug mouse renal epithelial lysate. Lane 2: 30ug mouse renal epithelial lysate. Lane 3: 30ug mouse renal epithelial lysate. Primary Antibody Dilution: 1:500. Secondary Antibody: Anti-rabbit-HRP. Secondary Antibody Dilution: 1:2500. Gene Name: KCNJ1. Submitted by: Dr. JUNMING FAN,ECU.; KCNJ1 antibody - middle region (ARP35432_P050) in Mouse renal epithelial cells using Western Blot Rabbit Aff - Purified African clawed frog, Can, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

KCNJ1 antibody

KCNJ1 Rabbit Serum Hu C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

KCNJ1 antibody

KCNJ1 Rabbit IgG Hu C, P, WB
0.5 mg / €400.00
  Novus Biologicals Inc.

KCNJ1 antibody

KCNJ1 Goat IgG Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

KCNJ1 antibody

KCNJ1 Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF
0.1 mg / €360.00
  Novus Biologicals Inc.

KCNJ1 antibody

KCNJ1 Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF
50 µg / €290.00
  Novus Biologicals Inc.

KCNJ1 antibody

Immunohistochemistry-Paraffin: KCNJ1 Antibody [NBP1-82874] - Immunohistochemical staining of human kidney shows distinct membranous positivity in distal renal tubules. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KCNJ1

KCNJ1 Human
2 µg / €300.00
  Abnova Taiwan Corp.

KCNJ1

KCNJ1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

KCNJ1

KCNJ1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

KCNJ1

KCNJ1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

KCNJ1

KCNJ1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

20 Item(s)

per page
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