KCNJ5 antibody

Principal name

KCNJ5 antibody

Alternative names for KCNJ5 antibody

KCNJ5, GIRK4, GIRK4, Inward rectifier K(+) channel Kir3.4, Heart KATP channel, KATP-1, Cardiac inward rectifier, CIR, G protein-activated inward rectifier potassium channel 4, Potassium channel, inwardly rectifying subfamily J member 5

SwissProt ID

O02670 (Pig), P48544 (Human), P48545 (Mouse), P48548 (Rat)

Gene ID

3762 (KCNJ5), 29713 (Kcnj5)

Available reactivities

Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Bov (Bovine), Eq (Equine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of KCNJ5 antibody

Kir3.4 is a member of the G-protein regulated inward-rectifier K+ (GIRK) channel subfamily which is part of an inward-rectifier K+ channel superfamily. The GIRK subfamily comprises four members in mammals (Kir3.1- Kir3.4) that present the common topology of the inward-rectifier superfamily: two transmembrane domains flanking a highly conserved pore region with the N and C-terminus located intracellularly.Kir3.4 and the other Kir3 family subunits can be activated by neurotransmitters and other factors via the activation of G-protein coupled receptors. Binding of the corresponding ligand to the G-protein receptor induces the dissociation of G a-GTP from the GÃ?? dimer. The latter directly binds to Kir3 and activates the channel. Kir3.4 expression is largely confined to the heart, where it co-assembles with Kir3.1 to form the prototypical muscarinic-gated K+ channel KACh. Indeed, knockout mice for Kir3.4 showed impaired heart rate following vagal nerve stimulatio peptide toxin origiting from the Apis mellifera bee venom, Tertiapin was shown to be a potent blocker of Kir3.4 containing channels (8.6 nM for the Kir3.1/3.4 combition).4

General readings

1. Molina-Navarro MM  et al. Differential gene expression of cardiac ion channels in human dilated cardiomyopathy. PLoS One 8:e79792 (2013). Human . PubMed: 24339868

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNJ5 antibody

  Rabbit polyclonal Anti-Kir3.4 (GIRK4)  
Western blot analysis of rat heart membranes: 1. Anti-Kir3.4 (GIRK4) antibody , (1:200). 2. Anti-Kir3.4 (GIRK4) antibody, preincubated with the control antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNJ5 antibody

  Rabbit Polyclonal Anti-KCNJ5 Antibody  
WB Suggested Anti-KCNJ5 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNJ5 antibody

KCNJ5 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

KCNJ5 antibody

Immunofluorescence analysis of A549 cells, using KCNJ5 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
50 µg / €230.00
  Assay Biotech

KCNJ5 antibody

Immunofluorescence analysis of A549 cells, using KCNJ5 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

KCNJ5 - human gene knockout kit via CRISPR

KCNJ5 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

KCNJ5 - human gene knockout kit via CRISPR

KCNJ5 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNJ5 - human gene knockout kit via CRISPR

KCNJ5 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNJ5 - human gene knockout kit via CRISPR

KCNJ5 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KCNJ5

  Recombinant protein of human potassium inwardly-rectifying channel, subfamily J, member 5 (KCNJ5)  
KCNJ5 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

KCNJ5 overexpression lysate

KCNJ5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KCNJ5 (mGFP-tagged) - Human potassium inwardly-rectifying channel, subfamily J, member 5 (KCNJ5), 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNJ5 (mGFP-tagged) - Human potassium inwardly-rectifying channel, subfamily J, member 5 (KCNJ5), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNJ5 (Myc-DDK tagged) - Human potassium inwardly-rectifying channel, subfamily J, member 5 (KCNJ5) , 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNJ5 (Myc-DDK tagged) - Human potassium inwardly-rectifying channel, subfamily J, member 5 (KCNJ5) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Kcnj5 (GFP-tagged ORF) - Rat potassium inwardly-rectifying channel, subfamily J, member 5 (Kcnj5), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnj5 (GFP-tagged ORF) - Rat potassium inwardly-rectifying channel, subfamily J, member 5 (Kcnj5), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Kcnj5 (Myc-DDK-tagged ORF) - Rat potassium inwardly-rectifying channel, subfamily J, member 5 (Kcnj5), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnj5 (Myc-DDK-tagged ORF) - Rat potassium inwardly-rectifying channel, subfamily J, member 5 (Kcnj5), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

15 Item(s)

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