KCNJ6 antibody

Principal name

KCNJ6 antibody

Alternative names for KCNJ6 antibody

KCNJ6, GIRK2, KATP2, KCNJ7, GIRK2, Inward rectifier K(+) channel Kir3.2, KATP-2, BIR1, G protein-activated inward rectifier potassium channel 2, Potassium channel, inwardly rectifying subfamily J member 6

SwissProt ID

P48051 (Human), P48542 (Mouse), P48550 (Rat), P49658 (Mesau), Q5NVJ6 (Ponab)

Gene ID

3763 (KCNJ6), 16522 (Kcnj6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Hst (Hamster), Mky (Monkey), Por (Porcine), Rb (Rabbit), Gorilla

Available hosts

Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of KCNJ6 antibody

Kir3.2 (or G-protein regulated Inward-Rectifier K+ channel, GIRK2) is a member of the family of inward rectifying K+ channels. The family includes 15 members that are structurally and functiolly different from the voltage-dependent K+ channels. The family’s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functiol unit for the Kir channels is composed of four subunit that can assembly as either homo or heterotetramers. Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis. Kir3.2 is a member of the Kir3.x subfamily that includes four members (Kir3.1- Kir3.4). The Kir3 family is characterized by the fact that the channels can be activated by neurotransmitters and other factors acting via the activation of G-protein coupled receptors. Binding of the corresponding ligand to the G-protein receptor induces the dissociation of Gα-GTP from the Gbg dimer. The latter directly binds to Kir3 and activates the channel. Kir3.2 is mainly expressed in the brain, were it co-assembles with Kir3.1 or Kir3.3 and mediates the inhibitory effects of many neurotransmitters including opioid, adrenergic, muscarinic, dopaminergic and γ-aminobutyric acid (GABA). Point mutations in the mouse Kir3.2 channel cause the weaver (wv) phenotype, a neurological abnormality characterized by the abnormal ‘weaving’ of the mice when they walk, hence the me weaver which is due to a substantial loss of cerebellar granule neurons. These mice also display mild local motor hyperactivity, presumably caused by the degeneration of dopaminergic neurons in the substantia nigra, spontaneous seizures and male sterility. A peptide toxin origiting from the Apis mellifera bee venom, Tertiapin (#STT-250) was shown to be a potent blocker of Kir3.2 containing channels (7 nM for Kir3.2 alone and 5.4 nM for the Kir3.1/3.2 combition).

General readings

Lu M, Lin SC, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H.
XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization.
Mol Cell. 2007 Jun 8;26(5):689-702.
PMID: 17560374

12 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNJ6 antibody

TA303283 (1µg/ml) staining of Human Brain (Substantia Nigra) lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNJ6 antibody

Anti-KCNJ6 / GIRK2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Bov, Can, Eq, Gorilla, GP, Hst, Hu, Mky, Ms, Por, Rb, Rt
50 µg / €345.00
  OriGene Technologies, Inc.

KCNJ6 antibody

Anti-KCNJ6 / GIRK2 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Bov, Can, Eq, Gorilla, Hst, Hu, Mky, Ms, Por, Rt
50 µg / €345.00
  OriGene Technologies, Inc.

KCNJ6 antibody

Western blot analysis of rat brain membranes: 1. Anti-Kir3.2 (GIRK2) antibody , (1:200). 2. Anti-Kir3.2 (GIRK2) antibody, preincubated with the control antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNJ6 antibody

KCNJ6 Rabbit Purified Hu, Ms C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

KCNJ6 antibody

KCNJ6 polyclonal antibody ( Cat # PAB7366 ) ( 1 µg/ml ) staining of human brain ( substantia nigra ) lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

KCNJ6 antibody

NB100-74575 (1ug/ml) staining of Human Brain (Substantia Nigra) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

KCNJ6 antibody

KCNJ6 Rabbit Serum Hu, Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KCNJ6

KCNJ6 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

KCNJ6

KCNJ6 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

KCNJ6

KCNJ6 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

KCNJ6 overexpression lysate

KCNJ6 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

12 Item(s)

per page
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