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KCNJ8 antibody

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Principal name

KCNJ8 antibody

Alternative names for KCNJ8 antibody

Kir6.1, uKATP-1, ATP-sensitive inward rectifier potassium channel 8, Potassium channel inwardly rectifying subfamily J member 8

SwissProt ID

P97794 (Mouse), Q15842 (Human), Q63664 (Rat)

Gene ID

3764 (KCNJ8), 25472 (Kcnj8)

Ncbi ID

9606, NP_004973, NP_004973.1, NP_058795.3

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Goat, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of KCNJ8 antibody

Kir 6.1 is a member of the inward rectifier K+ channels (Kir channels), a large family of voltage-independent K+ channels largely involved in stabilization of the membrane resting potential and in K+ transport across membranes. Kir 6.1 like its close relative Kir 6.2 is highly sensitive to inhibition by intracellular ATP. Closure of the channel leads to membrane depolarization hence coupling intracellular metabolism to cellular excitability. Kir 6.1 presents the common topology of the inward-rectifier superfamily: two transmembrane domains flanking a highly conserved pore region with the N and C-terminus located intracellularly. The functiol ATP sensitive channel (KATP) is composed of octamers of four Kir 6.x subunits and four members of the sulfonylurea receptor family SUR1, SUR2A and SUR2B. Kir 6.1 tissue distribution is relatively broad with expression detected in heart, brain, and smooth muscle. We are pleased to introduce an antibody against a highly specific region in the C-termil intracellular domain of the rat Kir 6.1 subunit. Anti-Kir 6.1 antibody (#APC-105) should also recognize Kir 6.1 from human, mouse, pig and rabbit origin.

General readings

Medeiros-Domingo, A., et al. Heart Rhythm 7(10):1466-1471(2010)
Ellis, J.A., et al. Physiol. Genomics 40(3):184-188(2010)
Shi, W., et al. J. Biol. Chem. 285(5):3021-3029(2010)
Winkler, M., et al. J. Biol. Chem. 284(11):6752-6762(2009)
Ploug, K.B., et al. Eur. J. Pharmacol. 601 (1-3), 43-49 (2008)

ARP35169_P050 - KCNJ8
Human HeLa; WB Suggested Anti-KCNJ8 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Hela cell lysate; KCNJ8 antibody - middle region (ARP35169_P050) in Human HeLa cells using Western Blot
AP52312PU-N - KCNJ8
Immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue reacted with KCNJ8 Antibody (N-term) Cat.-No AP52312PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining.
AP52312PU-N - KCNJ8
Western blot analysis of KCNJ8 Antibody (N-term) Cat.-No AP52312PU-N in CEM cell line lysates (35ug/lane). This demonstrates the KCNJ8 antibody detected the KCNJ8 protein (arrow).
NBP1-87710 - KCNJ8
Immunohistochemistry-Paraffin: Kir6.1 Antibody [NBP1-87710] - Immunohistochemical staining of human skin shows strong cytoplasmic positivity.
NBP1-87710 - KCNJ8
Western Blot: Kir6.1 Antibody [NBP1-87710] Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11 | Lane 2: RT-4 | Lane 3: U-251 MG | Lane 4: Human Plasma | Lane 5: Liver | Lane 6: Tonsil
GTX47687 - KCNJ8
Detection of KCNJ8 in Hela using anti-KCNJ8 antibody (GTX47687) at 1 µg/mL.
bs-6468R - KCNJ8
Lane 1: mouse brain lysates Lane 2: mouse heart lysates probed with Anti kir 6.1/IRK8 Polyclonal Antibody, Unconjugated (bs-6468R) at 1:200 in 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 90min in 37˚C. Predicted band 47kD. Observed band size: 47kD.
bs-6468R - KCNJ8
Formalin-fixed and paraffin embedded mouse heart tissue labeled with Anti-kir 6.1/IRK8 Polyclonal Antibody, Unconjugated (bs-6468R) at 1:200 followed by conjugation to the secondary antibody
TA328967 - KCNJ8
Western blot analysis of rat heart membranes: 1. Anti-Kir6.1 antibody , (1:200). 2. Anti-Kir6.1 antibody, preincubated with the control peptide antigen.
TA328967 - KCNJ8
Western blot analysis of rat cortex lysate: 1. Anti-Kir6.1 antibody , (1:200). 2. Anti-Kir6.1 antibody, preincubated with the control peptide antigen.
TA328967 - KCNJ8
Expression of Kir6.1 in rat uterus. Immunohistochemical stain of pregnant rat longitudinal section of the myometrium using Anti-Kir6.1 antibody , (1:50). Strong and specific staining is evident in smooth muscles cells both in the myometrium (blue arrow) and muscular layers of blood vessels (green arrow). Peroxidase reaction with DAB were used for the color reaction. Hematoxilin is used as the counterstain.
TA338551 - KCNJ8
WB Suggested Anti-KCNJ8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Hela cell lysate

9 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNJ8 antibody
Western blot analysis of rat heart membranes: 1. Anti-Kir6.1 antibody , (1:200). 2. Anti-Kir6.1 antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.
+2 additional images

KCNJ8 antibody
WB Suggested Anti-KCNJ8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Hela cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNJ8 antibody
Left: immunoblot against extracts of COS cells transiently transfected with Myc-tagged Kir6.1, HAtagged Kir6.2 or untagged Kv2.1 plasmid probed with N366/60 (left) or N52A/42 (right) TC supe. Right: adult rat brain membrane immunoblot Mouse IgG2a N366/60 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

KCNJ8 antibody
Left: immunoblot against extracts of COS cells transiently transfected with Myc-tagged Kir6.1, HAtagged Kir6.2 or untagged Kv2.1 plasmid probed with N366/60 (left) or N52A/42 (right) TC supe. Right: adult rat brain membrane immunoblot Mouse IgG2a N366/60 Purified Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

KCNJ8 (N-term) antibody
Immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue reacted with KCNJ8 Antibody (N-term) Cat.-No AP52312PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH
+1 additional image

KCNJ8 antibody
Human HeLa; WB Suggested Anti-KCNJ8 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Hela cell lysate; KCNJ8 antibody - middle region (ARP35169_P050) in Human HeLa cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

KCNJ8 antibody
KCNJ8 Rabbit Serum Hu, Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

KCNJ8 antibody
KCNJ8 Goat Purified Hu, Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

KCNJ8 antibody
Immunohistochemistry-Paraffin: Kir6.1 Antibody [NBP1-87710] - Immunohistochemical staining of human skin shows strong cytoplasmic positivity. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.
+1 additional image

9 Item(s)

per page

Available Filters

Product Type
  1. Primary Antibody (9)
Clonality
  1. Polyclonal (7)
  2. Monoclonal (2)
Target
  1. KCNJ8 (9)
Property
  1. N-term (1)
Reactivity
  1. Rat (Rt) (7)
  2. Human (Hu) (6)
  3. Mouse (Ms) (6)
  4. Bovine (Bov) (2)
  5. Canine (Can) (2)
  6. Porcine (Por) (2)
  7. Rabbit (Rb) (2)
  8. Zebrafish (Ze) (2)
  9. African clawed frog (1)
  10. Equine (Eq) (1)
  11. Guinea Pig (GP) (1)
Applications
  1. Western blot / Immunoblot (WB) (9)
  2. Paraffin Sections (P) (4)
  3. Frozen sections (C) (3)
  4. Immunocytochemistry/​Immunofluorescence (ICC/IF) (2)
Presentation
  1. Purified (4)
  2. Aff - Purified (3)
  3. Serum (1)
  4. Supernatant (1)
Host
  1. Rabbit (6)
  2. Mouse (2)
  3. Goat (1)
Images
  1. 1 image (7)
  2. 3+ images (1)
Images: Applications
  1. Western blot / Immunoblot (WB) (7)
  2. Paraffin Sections (P) (2)
  3. IHC (1)
Manufacturer
  1. Acris - OriGene (3)
  2. Novus Biologicals Inc. (3)
  3. Antibodies Incorporated (2)
  4. AVIVA Systems Biology (1)
Service
  • OriGene EU
  • Acris Antibodies GmbH
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