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KCNJ8 antibody

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Principal name

KCNJ8 antibody

Alternative names for KCNJ8 antibody

Kir6.1, uKATP-1, ATP-sensitive inward rectifier potassium channel 8, Potassium channel inwardly rectifying subfamily J member 8

SwissProt ID

P97794 (Mouse), Q15842 (Human), Q63664 (Rat)

Gene ID

3764 (KCNJ8), 25472 (Kcnj8), 16523

Ncbi ID

NP_004973, NP_058795.3, NP_004973.1, NM_008428, NM_017099, NM_004982

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of KCNJ8 antibody

Kir 6.1 is a member of the inward rectifier K+ channels (Kir channels), a large family of voltage-independent K+ channels largely involved in stabilization of the membrane resting potential and in K+ transport across membranes. Kir 6.1 like its close relative Kir 6.2 is highly sensitive to inhibition by intracellular ATP. Closure of the channel leads to membrane depolarization hence coupling intracellular metabolism to cellular excitability. Kir 6.1 presents the common topology of the inward-rectifier superfamily: two transmembrane domains flanking a highly conserved pore region with the N and C-terminus located intracellularly. The functiol ATP sensitive channel (KATP) is composed of octamers of four Kir 6.x subunits and four members of the sulfonylurea receptor family SUR1, SUR2A and SUR2B. Kir 6.1 tissue distribution is relatively broad with expression detected in heart, brain, and smooth muscle. We are pleased to introduce an antibody against a highly specific region in the C-termil intracellular domain of the rat Kir 6.1 subunit. Anti-Kir 6.1 antibody (#APC-105) should also recognize Kir 6.1 from human, mouse, pig and rabbit origin.

General readings

Medeiros-Domingo, A., et al. Heart Rhythm 7(10):1466-1471(2010)
Ellis, J.A., et al. Physiol. Genomics 40(3):184-188(2010)
Shi, W., et al. J. Biol. Chem. 285(5):3021-3029(2010)
Winkler, M., et al. J. Biol. Chem. 284(11):6752-6762(2009)
Ploug, K.B., et al. Eur. J. Pharmacol. 601 (1-3), 43-49 (2008)

ARP35169_P050 - KCNJ8
Human HeLa; WB Suggested Anti-KCNJ8 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Hela cell lysate; KCNJ8 antibody - middle region (ARP35169_P050) in Human HeLa cells using Western Blot
AP52312PU-N - KCNJ8
Immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue reacted with KCNJ8 Antibody (N-term) Cat.-No AP52312PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining.
AP52312PU-N - KCNJ8
Western blot analysis of KCNJ8 Antibody (N-term) Cat.-No AP52312PU-N in CEM cell line lysates (35ug/lane). This demonstrates the KCNJ8 antibody detected the KCNJ8 protein (arrow).
TA328967 - KCNJ8
Western blot analysis of rat heart membranes: 1. Anti-Kir6.1 antibody , (1:200). 2. Anti-Kir6.1 antibody, preincubated with the control peptide antigen.
TA328967 - KCNJ8
Western blot analysis of rat cortex lysate: 1. Anti-Kir6.1 antibody , (1:200). 2. Anti-Kir6.1 antibody, preincubated with the control peptide antigen.
TA328967 - KCNJ8
Expression of Kir6.1 in rat uterus. Immunohistochemical stain of pregnant rat longitudinal section of the myometrium using Anti-Kir6.1 antibody , (1:50). Strong and specific staining is evident in smooth muscles cells both in the myometrium (blue arrow) and muscular layers of blood vessels (green arrow). Peroxidase reaction with DAB were used for the color reaction. Hematoxilin is used as the counterstain.
TA338551 - KCNJ8
WB Suggested Anti-KCNJ8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Hela cell lysate
73-394 - KCNJ8
Left: immunoblot against extracts of COS cells transiently transfected with Myc-tagged Kir6.1, HAtagged Kir6.2 or untagged Kv2.1 plasmid probed with N366/60 (left) or N52A/42 (right) TC supe.
Right: adult rat brain membrane immunoblot

11 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNJ8 antibody
  Rabbit polyclonal Anti-Kir6.1  
Western blot analysis of rat heart membranes: 1. Anti-Kir6.1 antibody , (1:200). 2. Anti-Kir6.1 antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €622.00
  OriGene Technologies, Inc.
+2 additional images

KCNJ8 antibody
  Rabbit Polyclonal Anti-KCNJ8 Antibody  
WB Suggested Anti-KCNJ8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Hela cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €360.00
  OriGene Technologies, Inc.

KCNJ8 antibody
Left: immunoblot against extracts of COS cells transiently transfected with Myc-tagged Kir6.1, HAtagged Kir6.2 or untagged Kv2.1 plasmid probed with N366/60 (left) or N52A/42 (right) TC supe. Right: adult rat brain membrane immunoblot Mouse IgG2a N366/60 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €460.00
  Antibodies Incorporated

KCNJ8 antibody
Left: immunoblot against extracts of COS cells transiently transfected with Myc-tagged Kir6.1, HAtagged Kir6.2 or untagged Kv2.1 plasmid probed with N366/60 (left) or N52A/42 (right) TC supe. Right: adult rat brain membrane immunoblot Mouse IgG2a N366/60 Purified Ms, Rt C, ICC/IF, WB
0.1 ml / €540.00
  Antibodies Incorporated

KCNJ8 (N-term) antibody
Immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue reacted with KCNJ8 Antibody (N-term) Cat.-No AP52312PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  OriGene Technologies GmbH
+1 additional image

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KCNJ8 (mGFP-tagged) - Human potassium inwardly-rectifying channel, subfamily J, member 8 (KCNJ8), 200 uL, >10^7 TU/mL
Lenti ORF particles, KCNJ8 (mGFP-tagged) - Human potassium inwardly-rectifying channel, subfamily J, member 8 (KCNJ8), 200 uL, >10^7 TU/mL  
200 µl / €1,082.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, KCNJ8 (Myc-DDK tagged) - Human potassium inwardly-rectifying channel, subfamily J, member 8 (KCNJ8) , 200 uL, >10^7 TU/mL
Lenti ORF particles, KCNJ8 (Myc-DDK tagged) - Human potassium inwardly-rectifying channel, subfamily J, member 8 (KCNJ8) , 200 uL, >10^7 TU/mL  
200 µl / €969.00
  OriGene Technologies, Inc.
 

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Kcnj8 (GFP-tagged) - Mouse potassium inwardly-rectifying channel, subfamily J, member 8 (Kcnj8), 200 uL, >10^7 TU/mL
Lenti ORF particles, Kcnj8 (GFP-tagged) - Mouse potassium inwardly-rectifying channel, subfamily J, member 8 (Kcnj8), 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Kcnj8 (Myc-DDK-tagged) - Mouse potassium inwardly-rectifying channel, subfamily J, member 8 (Kcnj8), 200 uL, >10^7 TU/mL
Lenti ORF particles, Kcnj8 (Myc-DDK-tagged) - Mouse potassium inwardly-rectifying channel, subfamily J, member 8 (Kcnj8), 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.
 

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Kcnj8 (GFP-tagged ORF) - Rat potassium inwardly-rectifying channel, subfamily J, member 8 (Kcnj8), 200 uL, >10^7 TU/mL
Lenti ORF particles, Kcnj8 (GFP-tagged ORF) - Rat potassium inwardly-rectifying channel, subfamily J, member 8 (Kcnj8), 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Kcnj8 (Myc-DDK-tagged ORF) - Rat potassium inwardly-rectifying channel, subfamily J, member 8 (Kcnj8), 200 uL, >10^7 TU/mL
Lenti ORF particles, Kcnj8 (Myc-DDK-tagged ORF) - Rat potassium inwardly-rectifying channel, subfamily J, member 8 (Kcnj8), 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.
 

11 Item(s)

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11 products - FILTER YOUR RESULTS!

Available Filters

Product Type
  1. Human Lenti ORF Particle (2)
  2. Mouse Lenti ORF Particle (2)
  3. Primary Antibody (5)
  4. Rat Lenti ORF Particle (2)
Clonality
  1. Polyclonal (3)
  2. Monoclonal (2)
Target
  1. KCNJ8 (5)
Property
  1. N-term (1)
Reactivity
  1. Rat (Rt) (4)
  2. Mouse (Ms) (3)
  3. Human (Hu) (2)
  4. Bovine (Bov) (1)
  5. Canine (Can) (1)
  6. Equine (Eq) (1)
  7. Guinea Pig (GP) (1)
  8. Porcine (Por) (1)
  9. Rabbit (Rb) (1)
  10. Zebrafish (Ze) (1)
Applications
  1. Western blot / Immunoblot (WB) (5)
  2. Frozen sections (C) (2)
  3. Immunocytochemistry/​Immunofluorescence (ICC/IF) (2)
  4. Paraffin Sections (P) (1)
Presentation
  1. Purified (3)
  2. Aff - Purified (1)
  3. Supernatant (1)
Host
  1. Rabbit (3)
  2. Mouse (2)
Images
  1. 1 image (5)
  2. 3+ images (1)
Images: Applications
  1. Western blot / Immunoblot (WB) (5)
  2. IHC (1)
  3. Paraffin Sections (P) (1)
Manufacturer
  1. Acris - OriGene (9)
  2. Antibodies Incorporated (2)
Service
  • OriGene Technologies GmbH
  • Schillerstraße 5
  • D-32052 Herford
  • Germany
  • phone: +49-5221-34606-0
  • free call: 0800-227 47 46 (Germany only)
  • fax: +49-5221-34606-11
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  • orders: ordering-de@origene.com
 
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