KCNJ8 antibody

Principal name

KCNJ8 antibody

Alternative names for KCNJ8 antibody

Kir6.1, uKATP-1, ATP-sensitive inward rectifier potassium channel 8, Potassium channel inwardly rectifying subfamily J member 8

SwissProt ID

P97794 (Mouse), Q15842 (Human), Q63664 (Rat)

Gene ID

3764 (KCNJ8), 25472 (Kcnj8)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Goat, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of KCNJ8 antibody

Kir 6.1 is a member of the inward rectifier K+ channels (Kir channels), a large family of voltage-independent K+ channels largely involved in stabilization of the membrane resting potential and in K+ transport across membranes. Kir 6.1 like its close relative Kir 6.2 is highly sensitive to inhibition by intracellular ATP. Closure of the channel leads to membrane depolarization hence coupling intracellular metabolism to cellular excitability. Kir 6.1 presents the common topology of the inward-rectifier superfamily: two transmembrane domains flanking a highly conserved pore region with the N and C-terminus located intracellularly. The functiol ATP sensitive channel (KATP) is composed of octamers of four Kir 6.x subunits and four members of the sulfonylurea receptor family SUR1, SUR2A and SUR2B. Kir 6.1 tissue distribution is relatively broad with expression detected in heart, brain, and smooth muscle. We are pleased to introduce an antibody against a highly specific region in the C-termil intracellular domain of the rat Kir 6.1 subunit. Anti-Kir 6.1 antibody (#APC-105) should also recognize Kir 6.1 from human, mouse, pig and rabbit origin.

General readings

Medeiros-Domingo, A., et al. Heart Rhythm 7(10):1466-1471(2010)
Ellis, J.A., et al. Physiol. Genomics 40(3):184-188(2010)
Shi, W., et al. J. Biol. Chem. 285(5):3021-3029(2010)
Winkler, M., et al. J. Biol. Chem. 284(11):6752-6762(2009)
Ploug, K.B., et al. Eur. J. Pharmacol. 601 (1-3), 43-49 (2008)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNJ8 antibody

Western blot analysis of rat heart membranes: 1. Anti-Kir6.1 antibody , (1:200). 2. Anti-Kir6.1 antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNJ8 antibody

WB Suggested Anti-KCNJ8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Hela cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNJ8 antibody

Left: immunoblot against extracts of COS cells transiently transfected with Myc-tagged Kir6.1, HAtagged Kir6.2 or untagged Kv2.1 plasmid probed with N366/60 (left) or N52A/42 (right) TC supe. Right: adult rat brain membrane immunoblot Mouse IgG2a N366/60 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

KCNJ8 antibody

Left: immunoblot against extracts of COS cells transiently transfected with Myc-tagged Kir6.1, HAtagged Kir6.2 or untagged Kv2.1 plasmid probed with N366/60 (left) or N52A/42 (right) TC supe. Right: adult rat brain membrane immunoblot Mouse IgG2a N366/60 Purified Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

KCNJ8 (N-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue reacted with KCNJ8 Antibody (N-term) Cat.-No AP52312PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

KCNJ8 antibody

Human HeLa; WB Suggested Anti-KCNJ8 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Hela cell lysate; KCNJ8 antibody - middle region (ARP35169_P050) in Human HeLa cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

KCNJ8 antibody

KCNJ8 Rabbit Serum Hu, Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

KCNJ8 antibody

KCNJ8 Goat Purified Hu, Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

KCNJ8 antibody

Immunohistochemistry-Paraffin: Kir6.1 Antibody [NBP1-87710] - Immunohistochemical staining of human skin shows strong cytoplasmic positivity. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

9 Item(s)

per page
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