KCNK18 antibody

Principal name

KCNK18 antibody

Alternative names for KCNK18 antibody

KCNK18, TRESK, TRIK, Potassium channel subfamily K member 18, TWIK-related individual potassium channel, TWIK-related spinal cord potassium channel

SwissProt ID

Q6Q1P3 (Rat), Q6VV64 (Mouse), Q7Z418 (Human)

Gene ID

338567 (KCNK18), 332396 (Kcnk18), 445371

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of KCNK18 antibody

K2P18.1 (also med TWIK-related spil cord K+ channel, TRESK or KCNK18) is a member of the 2-pore (2P) domain K+ channels family that in mammals includes 15 members. These channels show little time or voltage dependence and are considered to be â??leakâ? or â??backgroundâ? K+ channels, thereby generating background currents which help set the membrane resting potential and control cell excitation. The K2P channels have a sigture topology that includes four transmembrane domains and two pore domains with intracellular N- and C termini. It has been proposed that the functiol channel unit is a dimer. Different K2P family members are regulated by diverse physical and chemical stimuli including temperature, pH, mechanical stretch, inhalation anesthetics, sigling pathways (PKC and PKA), arachidonic acid, etc. K2P18.1 is the only K2P channel so far, whose current is activated following Gaq-receptor coupled activation. The enhancement of K2P18.1 current involves activation of calcineurin (calciumâ??calmodulin-dependent phosphatase 2B) following the rise in intracellular calcium that occurs subsequent to Gaq activation. In addition, K2P18.1 is potently activated by clinical concentrations of volatile anesthetics. K2P18.1 expression in humans is largely restricted to the spil cord although in rodents it has a broader expression pattern that includes brain, testis and spleen. K2P18.1 represents the most important background K+ channel in dorsal root ganglion neurons and hence it has been postulated that it has an important role in acute and chronic pain as well as general anesthesia.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNK18 antibody

  Rabbit polyclonal Anti-K2P18.1 (TRESK) (extracellular)  
Western blot analysis of rat brain (lanes 1 and 3) and dorsal root ganglion (lanes 2 and 4) membranes: 1, 2. Anti-K2P18.1 (TRESK) (extracellular) antibody , (1:200). 3, 4. Anti-K2P18.1 (TRESK) (extracellular), preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNK18 antibody

  Rabbit Polyclonal TRESK Antibody  
Western blot analysis of TRESK in rat brain tissue lysate with TRESK antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNK18 antibody

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

KCNK18 - human gene knockout kit via CRISPR

KCNK18 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

KCNK18 - human gene knockout kit via CRISPR

KCNK18 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNK18 - human gene knockout kit via CRISPR

KCNK18 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNK18 - human gene knockout kit via CRISPR

KCNK18 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnk18 - mouse gene knockout kit via CRISPR

Kcnk18 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Kcnk18 - mouse gene knockout kit via CRISPR

Kcnk18 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnk18 - mouse gene knockout kit via CRISPR

Kcnk18 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnk18 - mouse gene knockout kit via CRISPR

Kcnk18 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

KCNK18 overexpression lysate

KCNK18 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KCNK18 (mGFP-tagged) - Human potassium channel, subfamily K, member 18 (KCNK18), 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNK18 (mGFP-tagged) - Human potassium channel, subfamily K, member 18 (KCNK18), 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNK18 (Myc-DDK tagged) - Human potassium channel, subfamily K, member 18 (KCNK18) , 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNK18 (Myc-DDK tagged) - Human potassium channel, subfamily K, member 18 (KCNK18) , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Kcnk18 (GFP-tagged) - Mouse potassium channel, subfamily K, member 18 (Kcnk18), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnk18 (GFP-tagged) - Mouse potassium channel, subfamily K, member 18 (Kcnk18), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Kcnk18 (Myc-DDK-tagged) - Mouse potassium channel, subfamily K, member 18 (Kcnk18), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnk18 (Myc-DDK-tagged) - Mouse potassium channel, subfamily K, member 18 (Kcnk18), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Kcnk18 (GFP-tagged ORF) - Rat potassium channel, subfamily K, member 18 (Kcnk18), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnk18 (GFP-tagged ORF) - Rat potassium channel, subfamily K, member 18 (Kcnk18), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Kcnk18 (GFP-tagged ORF) - Rat potassium channel, subfamily K, member 18 (Kcnk18), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnk18 (GFP-tagged ORF) - Rat potassium channel, subfamily K, member 18 (Kcnk18), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Kcnk18 (Myc-DDK-tagged ORF) - Rat potassium channel, subfamily K, member 18 (Kcnk18), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnk18 (Myc-DDK-tagged ORF) - Rat potassium channel, subfamily K, member 18 (Kcnk18), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Lenti ORF particles, Kcnk18 (Myc-DDK-tagged ORF) - Rat potassium channel, subfamily K, member 18 (Kcnk18), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnk18 (Myc-DDK-tagged ORF) - Rat potassium channel, subfamily K, member 18 (Kcnk18), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

20 Item(s)

per page
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