KCNK18 antibody

Principal name

KCNK18 antibody

Alternative names for KCNK18 antibody

KCNK18, TRESK, TRIK, Potassium channel subfamily K member 18, TWIK-related individual potassium channel, TWIK-related spinal cord potassium channel

SwissProt ID

Q6Q1P3 (Rat), Q6VV64 (Mouse), Q7Z418 (Human)

Gene ID

338567 (KCNK18), 332396 (Kcnk18)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C)

Background of KCNK18 antibody

K2P18.1 (also med TWIK-related spil cord K+ channel, TRESK or KCNK18) is a member of the 2-pore (2P) domain K+ channels family that in mammals includes 15 members. These channels show little time or voltage dependence and are considered to be â??leakâ? or â??backgroundâ? K+ channels, thereby generating background currents which help set the membrane resting potential and control cell excitation. The K2P channels have a sigture topology that includes four transmembrane domains and two pore domains with intracellular N- and C termini. It has been proposed that the functiol channel unit is a dimer. Different K2P family members are regulated by diverse physical and chemical stimuli including temperature, pH, mechanical stretch, inhalation anesthetics, sigling pathways (PKC and PKA), arachidonic acid, etc. K2P18.1 is the only K2P channel so far, whose current is activated following Gaq-receptor coupled activation. The enhancement of K2P18.1 current involves activation of calcineurin (calciumâ??calmodulin-dependent phosphatase 2B) following the rise in intracellular calcium that occurs subsequent to Gaq activation. In addition, K2P18.1 is potently activated by clinical concentrations of volatile anesthetics. K2P18.1 expression in humans is largely restricted to the spil cord although in rodents it has a broader expression pattern that includes brain, testis and spleen. K2P18.1 represents the most important background K+ channel in dorsal root ganglion neurons and hence it has been postulated that it has an important role in acute and chronic pain as well as general anesthesia.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNK18 antibody

Western blot analysis of rat brain (lanes 1 and 3) and dorsal root ganglion (lanes 2 and 4) membranes: 1, 2. Anti-K2P18.1 (TRESK) (extracellular) antibody , (1:200). 3, 4. Anti-K2P18.1 (TRESK) (extracellular), preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNK18 antibody

Western blot analysis of TRESK in rat brain tissue lysate with TRESK antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNK18 antibody

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

KCNK18 Control Peptide

KCNK18
50 µg / €160.00
  Acris Antibodies GmbH

KCNK18 antibody

KCNK18 Rabbit Purified Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

KCNK18 antibody

Immunohistochemistry-Paraffin: KCNK18 Antibody [NBP1-77097] - Rat brain tissue with TRESK antibody at 5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

KCNK18 antibody

Immunohistochemistry-Paraffin: KCNK18 Antibody [NBP1-81570] Immunohistochemical staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KCNK18

KCNK18 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

KCNK18

KCNK18 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

KCNK18 overexpression lysate

KCNK18 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

10 Item(s)

per page
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