KCNK2 antibody

Principal name

KCNK2 antibody

Alternative names for KCNK2 antibody

KCNK2, TREK, TREK1, Potassium channel subfamily K member 2, Two pore potassium channel TPKC1, Outward rectifying potassium channel protein TREK-1, TREK-1 K(+) channel subunit, Two pore domain potassium channel TREK-1

SwissProt ID

O95069 (Human), P97438 (Mouse)

Gene ID

3776 (KCNK2), 16526 (Kcnk2)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of KCNK2 antibody

A potential new target for antidepressants. Nature Neuroscience pp 1134-1141. A potassium channel called TREK1 may represent a new target for antidepressant drugs, according to research published in the September issue of Nature Neuroscience. The channel may exert its effects through a signaling pathway in the brain different to that normally targeted by most conventional antidepressants, which are thought to work by increasing the level of the neurotransmitter serotonin in the brain. Michel Lazdunski and colleagues studied mice lacking the gene for the TREK1 channel, which normally contributes to the background currents that set the resting membrane potential of neurons. In several behavioral tests used to model depression, these mice behaved as if they had been treated with an antidepressant. In addition, they had increased serotonergic activity, and did not release as much of the stress hormone corticosterone as normal mice in response to mild stress. Moreover, the authors report that the TREK1 channel was also directly inhibited by conventional antidepressants. The finding that mice lacking the gene for TREK1 behave as if they have been given an antidepressant suggests that small molecule 'blockers' of the potassium channel might be effective therapeutically. If TREK1 is found to exert its antidepressant effects through a pathway independent of serotonin, it is possible that future therapies targeting TREK1 channels may be faster acting and may have fewer side effects than conventional antidepressants. Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype pp. 1134-1141. Heurteaux C, Lucas G, Guy N, El Yacoubi M, Thummler S, Peng XD, Noble F, Blondeau N, Widmann C, Borsotto M, Gobbi G, Vaugeois JM, Debonnel G, Lazdunski M. Published online: 13 Aug 2006 | doi:10.1038/nn1749 TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.

13 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNK2 antibody

Detection of TREK 1 in human brain membrane lysate Rabbit IgG Purified Bov, Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNK2 antibody

Western blot analysis of Trek-1 in Jurkat cell lysates (Lane 1, 2), 3T3 cell lysate (Lane 3), and rat kidney tissue lysate (Lane 4). Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNK2 antibody

Western blot analysis of rat brain membranes: 1. Anti-K2P2.1 (TREK-1) antibody, (1:200). 2. Anti-K2P2.1 (TREK-1) antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNK2 (4-14) antibody

Western blot analysis of Jurkat cell extract using rabbit anti-trek1. Rabbit Azide Free Hu E, WB
0.5 mg / €680.00
  Acris Antibodies GmbH

KCNK2 (4-14) antibody

Western blot analysis of Jurkat cell extract using rabbit anti-trek1. Rabbit Azide Free Hu E, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

KCNK2 antibody

KCNK2 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

KCNK2 antibody

KCNK2 Rabbit Ms E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

KCNK2 antibody

Western blot analysis of Kcnk2 experssion in Jurkat cell lysates ( Lane 1 ) , NIH/3T3 cell lysate ( Lane 2 ) , and rat kidney tissue lysate ( Lane 3 ) . Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

KCNK2 (N-term) antibody

Detection of TREK 1 in human brain membrane lysate. Rabbit IgG Aff - Purified Bov, Hu, Ms WB
0.1 ml / €330.00
  Neuromics Antibodies

KCNK2 antibody

KCNK2 Rabbit Biotin Hu WB
0.1 ml / €360.00
  Novus Biologicals Inc.

KCNK2 antibody

KCNK2 Rabbit DyLight488 Hu WB
0.1 ml / €390.00
  Novus Biologicals Inc.

KCNK2 antibody

KCNK2 Rabbit HRP Hu WB
0.1 ml / €390.00
  Novus Biologicals Inc.

KCNK2 antibody

KCNK2 Rabbit Aff - Purified Bov, Hu, Ms WB
25 µl / €160.00
  Novus Biologicals Inc.

13 Item(s)

per page
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