KCNK3 antibody

Principal name

KCNK3 antibody

Alternative names for KCNK3 antibody

KCNK3, TASK, TASK1, Potassium channel subfamily K member 3, Acid-sensitive potassium channel protein TASK-1, TWIK-related acid-sensitive K(+) channel 1, Two pore potassium channel KT3.1

SwissProt ID

O14649 (Human), O35111 (Mouse), O54912 (Rat)

Gene ID

3777 (KCNK3), 29553 (Kcnk3), 16527

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), GP (Guinea Pig), Sh (Sheep)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of KCNK3 antibody

K2P3.1 (also med TWIK-Related Acid Sensitive K+ channel, TASK-1 or KCNK3) is a member of the 2-pore (2P) domain K+ channels family that includes at least 16 members. These channels show little time or voltage dependence and are considered to be â??leakâ? or â??backgroundâ? K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation. The K2P channels have a sigture topology that includes four transmembrane domains and two pore domains with intracellular N- and C termini. The functiol channel is believed to be a dimer. K2P channels are regulated by diverse physical and chemical stimuli including temperature, changes in intracellular pH, mechanical stretch, inhalation anesthetics, etc. The channels can then be subclassified based in their specific activators. K2P3.1 is extremely sensitive to variations in exterl pH, a drop in pH from 7.7 to 6.7 will be enough to close most K2P3.1 channels. K2P3.1 channel distribution is relatively wide with high expression in the brain and heart as well as in the pancreas, kidney and lung. K2P3.1 can exist in the brain either as a homodimer or as a heterodimer with the closely related channel K2P9.1 (TASK-3). During periods of high neurol activity a transient increase in extracellular pH has been recorded. This pH increase may stimulate K2P3.1 channel activity and hence enhance outward K+ currents. This in turn will decrease excitability in these neurons and work as a feedback mechanism.

General readings

Rusznak,Z., et al., (2004) Cell. Mol. Life Sci. 61 (12), 1532-1542

16 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNK3 antibody

  Rabbit Polyclonal Anti-K2P3.1 (TASK-1)  
Western blot analysis of rat brain (1,3) and pancreas (2,4) membranes: 1,2. Anti-K2P3.1 (TASK-1) antibody, (1:200). 3,4. Anti-K2P3.1 (TASK-1) antibody, preincubated with the control peptide Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNK3 antibody

  Rabbit Polyclonal Anti-KCNK3 Antibody  
WB Suggested Anti-KCNK3 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1:1562500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Rb, Rt, Sh WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNK3 antibody

Immunoblot versus crude membranes from adult rat brain (RBM) and wild-type (WT) and TASK1 KO mouse brains probed with N374/48 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Doug Bayliss (University of Virginia). Mouse IgG2b N374/48 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €460.00
  Antibodies Incorporated

NeuroMab

KCNK3 antibody

Immunoblot versus crude membranes from adult rat brain (RBM) and wild-type (WT) and TASK1 KO mouse brains probed with N374/48 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Doug Bayliss (University of Virginia). Mouse IgG2b N374/48 Purified Ms, Rt C, ICC/IF, WB
0.1 ml / €540.00
  Antibodies Incorporated

NeuroMab

KCNK3 (251-411, Cytopl. Dom.) antibody

KCNK3 Mouse IgG2b S374-48 Purified Ms, Rt ICC/IF, P, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

KCNK3 - human gene knockout kit via CRISPR

KCNK3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

KCNK3 - human gene knockout kit via CRISPR

KCNK3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNK3 - human gene knockout kit via CRISPR

KCNK3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNK3 - human gene knockout kit via CRISPR

KCNK3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

KCNK3 overexpression lysate

KCNK3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KCNK3 (mGFP-tagged) - Human potassium channel, subfamily K, member 3 (KCNK3), 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNK3 (mGFP-tagged) - Human potassium channel, subfamily K, member 3 (KCNK3), 200 uL, >10^7 TU/mL  
200 µl / €970.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNK3 (Myc-DDK tagged) - Human potassium channel, subfamily K, member 3 (KCNK3) , 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNK3 (Myc-DDK tagged) - Human potassium channel, subfamily K, member 3 (KCNK3) , 200 uL, >10^7 TU/mL  
200 µl / €870.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Kcnk3 (GFP-tagged) - Mouse potassium channel, subfamily K, member 3 (Kcnk3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnk3 (GFP-tagged) - Mouse potassium channel, subfamily K, member 3 (Kcnk3), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Kcnk3 (Myc-DDK-tagged) - Mouse potassium channel, subfamily K, member 3 (Kcnk3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnk3 (Myc-DDK-tagged) - Mouse potassium channel, subfamily K, member 3 (Kcnk3), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Kcnk3 (GFP-tagged ORF) - Rat potassium channel, subfamily K, member 3 (Kcnk3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnk3 (GFP-tagged ORF) - Rat potassium channel, subfamily K, member 3 (Kcnk3), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Kcnk3 (Myc-DDK-tagged ORF) - Rat potassium channel, subfamily K, member 3 (Kcnk3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnk3 (Myc-DDK-tagged ORF) - Rat potassium channel, subfamily K, member 3 (Kcnk3), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

16 Item(s)

per page
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