KCNK5 antibody

Principal name

KCNK5 antibody

Alternative names for KCNK5 antibody

KCNK5, TASK2, Potassium channel subfamily K member 5, Acid-sensitive potassium channel protein TASK-2, TWIK-related acid-sensitive K(+) channel 2

SwissProt ID

O95279 (Human)

Gene ID

8645 (KCNK5)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Rb (Rabbit), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of KCNK5 antibody

K2P5.1 (also med TWIK-Related Acid Sensitive K+ channel 2, TASK-2 or KCNK5) is a member of the 2-pore (2P) domain K+ channels family that includes at least 16 members. These channels show little time or voltage dependence and are considered to be “leak” or “background” K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation. The K2P channels have a sigture topology that includes four transmembrane domains and two pore domains with intracellular N- and C termini. The functiol channel is believed to be a dimer. K2P channels are regulated by diverse physical and chemical stimuli including temperature, changes in intracellular pH, mechanical stretch, inhalation anesthetics, etc. The channels can then be subclassified based in their specific activators. As indicated by its me, K2P5.1 is sensitive to variations in exterl pH. K2P5.1 current is maximal at pH 8.8 but it is only 10% at pH 6.5. The channel is expressed in several epithelial tissues including pancreas, lung, small intestine and specially kidney. In the kidney K2P5.1 has an important function in HCO3 absorption in the proximal tubule as knockout mice for K2P5.1 display metabolic acidosis and hypotension.

General readings

Rusznak,Z., et al., (2004) Cell. Mol. Life Sci. 61 (12), 1532-1542

6 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNK5 antibody

Western blot analysis of rat kidney membranes: 1. Anti-K2P5.1 (TASK-2) antibody, (1:200). 2. Anti-K2P5.1 (TASK-2) antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNK5 antibody

WB Suggested Anti-KCNK5 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNK5 antibody

WB Suggested Anti-Kcnk5 Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse Liver Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNK5 antibody

KCNK5 Mouse IgG1 2B4 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

KCNK5 antibody

Human HepG2; WB Suggested Anti-KCNK5 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: HepG2 cell lysate; KCNK5 antibody - C-terminal region (ARP37679_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Rb WB
50 µg / €350.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KCNK5

KCNK5 Human
2 µg / €300.00
  Abnova Taiwan Corp.

6 Item(s)

per page
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