KCNK9 antibody

Principal name

KCNK9 antibody

Alternative names for KCNK9 antibody

KCNK9, TASK3, Potassium channel subfamily K member 9, Two pore potassium channel KT3.2, Acid-sensitive potassium channel protein TASK-3, TWIK-related acid-sensitive K(+) channel 3

SwissProt ID

Q3LS21 (Mouse), Q9ES08 (Rat), Q9NPC2 (Human)

Gene ID

51305 (KCNK9), 84429 (Kcnk9)

Available reactivities

Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), African clawed frog, Bov (Bovine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts


Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of KCNK9 antibody

K2P9.1 (also med TASK3 or KCNK9) is a member of the 2-pore (2P) domain K+ channels family that probably assemble as dimers to constitute a functiol channel. These channels show little time or voltage dependence and are considered to be â??leakâ? or â??backgroundâ? K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation. The channels are regulated by diverse physical and chemical stimuli including temperature, pH, mechanical stretch, inhalation anesthetics, etc. The physiological role of the K2P channels is not yet clear, though they were proposed to participate in breathing, aldosterone secretion and anesthetic-mediated neurol activity. In human, expression of K2P9.1 is restricted in brain and its expression overlaps with the structurally related K2P3.1 (TASK1, KCNK3) channel. In rat, it is more widely expressed in other tissues as well as in brain. Unexpectedly, K2P9.1 was found to be over-expressed between 5 to 100-fold in 44% of breast cancer tumors tested. Transfection and over-expression of K2P9.1 in cell lines promotes tumor growth and confers resistance to hypoxia and serum deprivation. Recently, K2P9.1 was found to play an important role in K+-dependent apoptosis of cerebellar granules.

General readings

Rusznak,Z., (2008) Virchows Arch. 452 (4), 415-426

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNK9 antibody

WB Suggested Anti-KCNK9 Antibody Titration: 1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Rb, Rt ICC/IF, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNK9 antibody

Human Prostate; Immunohistochemistry with prostate cell lysate tissue at an antibody concentration of 5.0ug/ml using anti-KCNK9 antibody (ARP35260_P050); KCNK9 antibody - N-terminal region (ARP35260_P050) in Human Prostate cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Chk, Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

KCNK9 antibody

WB analysis of K2P9.1 in rat cerebellum (lanes 1, 4), human mammary gland MCF-10A (lanes 2, 5) and MCF-7 (lanes 3, 6) cell lysates (upper panel): 1-3. Anti-K2P9.1 (TASK-3) antibody . 4-6. Anti-K2P9.1 (TASK-3) antibody, preincubated with the control peptide antigen. Lower panel: anti-beta-actin to ensure equal loading. Note that the expected 50 kD MW band is present in cerebellum and in the tumorigenic breast cancer cell line (MCF-7) but not in the non-tumorigenic breast cell line (MCF-10A). Rabbit Purified Hu, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

3 Item(s)

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