KCNMA1 antibody

Principal name

KCNMA1 antibody

Alternative names for KCNMA1 antibody

Maxi K, BK, K VCA, BKCA channel, Slowpoke homolog, Slo-alpha, Slo1, hSlo, Calcium-activated potassium channel subunit alpha-1

SwissProt ID

O18866 (Pig), Q08460 (Mouse), Q12791 (Human), Q28204 (Bovin), Q28265 (Canfa), Q62976 (Rat), Q7TQ57 (Rat), Q8AYS8 (Chick), Q90ZC7 (Xenla), Q96LG8 (Human), Q9BG98 (Rabit)

Gene ID

3778 (KCNMA1), 16531 (Kcnma1), 83731

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), African clawed frog, Hst (Hamster), Mky (Monkey), Xen (Xenopus), Eq (Equine), GP (Guinea Pig), Sh (Sheep)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of KCNMA1 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels. The Slo1 channel is a novel potassium channel that is regulated by both Ca2+ and voltage. It is a homolog to the pH and voltage-regulated Slo3 channel. Four distinct subunits composing the KCNMB family are known to regulate the function and expression of Slo1 channels. Slo1 has been shown to be involved in neurotransmitter release and etheanol response. It has been reported that SLO1 also has a critical role is muscles- the inactivation of the slo-1 gene in muscles leased to phenotypes similar to those cause by mutations of the dystrophin homologue dys-1.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNMA1 antibody

  Rabbit Polyclonal Anti-KCNMA1 Antibody  
WB Suggested Anti-KCNMA1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNMA1 antibody

  Mouse Monoclonal anti-slo1 Antibody  
IHC analysis of Slo using anti-slo1, tested on mouse cerebellum tissues.? Nuclear staining of oligodendrocytes and microglial cells of the white matter. Neurons are negative. Mouse IgG2a S6-60 Purified Hu, Ms, Rt, Ze C, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNMA1 antibody

  KCNMA1 / BK Rabbit Polyclonal (Internal) Antibody  
Anti-KCNMA1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Can, Chk, Hst, Hu, Mky, Ms, Por, Rb, Rt, Xen, Ze
50 µg / €400.00
  OriGene Technologies, Inc.

KCNMA1 antibody

  KCNMA1 / BK Rabbit Polyclonal (Internal) Antibody  
Anti-KCNMA1 antibody IHC of human breast, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Chk, Eq, Hst, Hu, Mky, Ms, Por, Rb, Rt, Xen, Ze
50 µg / €400.00
  OriGene Technologies, Inc.

KCNMA1 antibody

  Rabbit polyclonal Anti-KCa1.1 (1098-1196)  
Western blot analysis of rat brain membranes: 1. Anti-KCa1.1 (1097-1196) antibody , (1:200). 2. Anti-KCa1.1 (1097-1196) antibody, preincubated with the control antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNMA1 antibody

  Rabbit polyclonal Anti-KCa1.1 (1184-1200)  
Western blot analysis of rat brain membranes: 1. Anti-KCa1.1 (1184-1200) antibody , (1:500). 2. Anti-KCa1.1 (1184-1200) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNMA1 antibody

  Rabbit polyclonal Anti-KCa1.1 (BKCa) (extracellular)  
Western blot analysis of rat (lanes 1 and 3) and mouse brain membranes (lanes 2 and 4): 1, 2. Anti-KCa1.1 (BKCa) (extracellular) antibody , (1:200). 3, 4. Anti-KCa1.1 (BKCa) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNMA1 antibody

  Rabbit polyclonal Anti-KCNMA1 Antibody  
WB Suggested Anti-KCNMA1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Hela cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNMA1 antibody

  Rabbit Polyclonal Anti-KCNMA1 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using (KCNMA1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNMA1 antibody

Top: adult rat hippocampus immunohistochemistry. 
Bottom: immunofluorescence staining of hippocampal CA3 of adult WT and Slo1 KO mice with L6/60 (red) and Kv2.1 rabbit polyclonal (green). Mouse IgG2a L6/60 Supernatant Hu, Ms, Rt, Ze C, ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNMA1 antibody

Top: adult rat hippocampus immunohistochemistry. 
Bottom: immunofluorescence staining of hippocampal CA3 of adult WT and Slo1 KO mice with L6/60 (red) and Kv2.1 rabbit polyclonal (green). Mouse IgG2a L6/60 Purified Hu, Ms, Rt, Ze C, ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNMA1 antibody

Immunohistochemistry analyzes of MaxiKα antibody (Cat.-No.: AP20653PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

KCNMA1 - human gene knockout kit via CRISPR

KCNMA1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

KCNMA1 - human gene knockout kit via CRISPR

KCNMA1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNMA1 - human gene knockout kit via CRISPR

KCNMA1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNMA1 - human gene knockout kit via CRISPR

KCNMA1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnma1 - mouse gene knockout kit via CRISPR

Kcnma1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Kcnma1 - mouse gene knockout kit via CRISPR

Kcnma1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnma1 - mouse gene knockout kit via CRISPR

Kcnma1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnma1 - mouse gene knockout kit via CRISPR

Kcnma1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

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