KCNMA1 antibody

Principal name

KCNMA1 antibody

Alternative names for KCNMA1 antibody

Maxi K, BK, K VCA, BKCA channel, Slowpoke homolog, Slo-alpha, Slo1, hSlo, Calcium-activated potassium channel subunit alpha-1

SwissProt ID

O18866 (Pig), Q08460 (Mouse), Q12791 (Human), Q28204 (Bovin), Q28265 (Canfa), Q62976 (Rat), Q7TQ57 (Rat), Q8AYS8 (Chick), Q90ZC7 (Xenla), Q96LG8 (Human), Q9BG98 (Rabit)

Gene ID

3778 (KCNMA1), 16531 (Kcnma1), 83731

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), African clawed frog, Hst (Hamster), Mky (Monkey), Xen (Xenopus), Eq (Equine), GP (Guinea Pig), Sh (Sheep)

Available hosts

Rabbit, Goat, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Immunoprecipitation (IP), Enzyme Immunoassay (E)

Background of KCNMA1 antibody

Function: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel also contains binding sites for Ca(2+) and Mg(2+).; Defects in KCNMA1 are the cause of generalized epilepsy and paroxysmal dyskinesia (GEPD). Epilepsy is one of the most common and debilitating neurological disorders. Paroxysmal dyskinesias are neurological disorders characterized by sudden, unpredictable, disabling attacks of involuntary movement often requiring life-long treatment. The coexistence of epilepsy and paroxysmal dyskinesia in the same individual or family is an increasingly recognized phenomenon. Patients manifest absence seizures, generalized tonic-clonic seizures, paroxysmal nonkinesigenic dyskinesia, involuntary dystonic or choreiform movements. Onset is usually in childhood and patients may have seizures only, dyskinesia only, or both.; Enzyme regulation: Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation.; Subcellular location: Membrane, Multi-pass membrane protein.; Tissue specificity: Widely expressed. Except in myocytes, it is almost ubiquitously expressed.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNMA1 antibody

WB Suggested Anti-KCNMA1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNMA1 antibody

Human Prostate; Prostate; KCNMA1 antibody - C-terminal (ARP35092_P050) in Human Prostate cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

KCNMA1 antibody

IHC analysis of Slo using anti-slo1, tested on mouse cerebellum tissues.? Nuclear staining of oligodendrocytes and microglial cells of the white matter. Neurons are negative. Mouse IgG2a S6-60 Purified Hu, Ms, Rt, Ze C, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNMA1 antibody

Anti-KCNMA1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Can, Chk, Hst, Hu, Mky, Ms, Por, Rb, Rt, Xen, Ze
50 µg / €345.00
  OriGene Technologies, Inc.

KCNMA1 antibody

Anti-KCNMA1 antibody IHC of human breast, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Chk, Eq, Hst, Hu, Mky, Ms, Por, Rb, Rt, Xen, Ze
50 µg / €345.00
  OriGene Technologies, Inc.

KCNMA1 antibody

Western blot analysis of rat brain membranes: 1. Anti-KCa1.1 (1097-1196) antibody , (1:200). 2. Anti-KCa1.1 (1097-1196) antibody, preincubated with the control antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNMA1 antibody

Western blot analysis of rat brain membranes: 1. Anti-KCa1.1 (1184-1200) antibody , (1:500). 2. Anti-KCa1.1 (1184-1200) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNMA1 antibody

Western blot analysis of rat (lanes 1 and 3) and mouse brain membranes (lanes 2 and 4): 1, 2. Anti-KCa1.1 (BKCa) (extracellular) antibody , (1:200). 3, 4. Anti-KCa1.1 (BKCa) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNMA1 antibody

WB Suggested Anti-KCNMA1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Hela cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNMA1 antibody

Top: adult rat hippocampus immunohistochemistry. 
Bottom: immunofluorescence staining of hippocampal CA3 of adult WT and Slo1 KO mice with L6/60 (red) and Kv2.1 rabbit polyclonal (green). Mouse IgG2a L6/60 Supernatant Hu, Ms, Rt, Ze C, ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNMA1 antibody

Top: adult rat hippocampus immunohistochemistry. 
Bottom: immunofluorescence staining of hippocampal CA3 of adult WT and Slo1 KO mice with L6/60 (red) and Kv2.1 rabbit polyclonal (green). Mouse IgG2a L6/60 Purified Hu, Ms, Rt, Ze C, ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNMA1 (690-1196) antibody

Immunohistochemistry analysis of Slo using AM20106PU-N tested on Mouse cerebellum tissues. Nuclear staining of oligodendrocytes and microglial cells of the white matter. Neurons are negative. Mouse IgG2a S6-60 Purified Hu, Ms, Rt, Ze C, ICC/IF, IP, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

KCNMA1 antibody

Immunohistochemistry analyzes of MaxiKα antibody (Cat.-No.: AP20653PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

KCNMA1 antibody

Human HeLa; WB Suggested Anti-KCNMA1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Hela cell lysate; KCNMA1 antibody - middle region (ARP37677_P050) in Human HeLa cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

KCNMA1 antibody

Western blot analysis of KCNMA1 expression in Caski (A); rat brain (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

KCNMA1 antibody

Western blot analysis of KCNMA1 expression in Caski (A); rat brain (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

KCNMA1 antibody

Western blot analysis of KCNMA1 expression in Caski (A); rat brain (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

KCNMA1 antibody

KCNMA1 Rabbit Serum Hu C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

KCNMA1 antibody

KCNMA1 Rabbit Purified Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

KCNMA1 antibody

KCNMA1 Mouse IgG2a S6-60 Purified Hu, Ms, Rt, Ze ICC/IF, IP, P, WB
0.1 mg / €450.00
  Novus Biologicals Inc.

20 Item(s)

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