KCNMB1 antibody

Principal name

KCNMB1 antibody

Alternative names for KCNMB1 antibody

subfamily M beta-1, Maxi K channel beta-1, BK channel beta-1, K VCAbeta-1, Slo-beta-1, Charybdotoxin receptor subunit beta-1, Calcium-activated potassium channel subunit beta-1

SwissProt ID

P97678 (Rat), Q16558 (Human), Q8CAE3 (Mouse)

Gene ID

3779 (KCNMB1), 29747 (Kcnmb1)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of KCNMB1 antibody

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits.


Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open. Maxi K+ beta is the target for possible therapeutics because of its role in blood flow and blood pressure regulation.

General readings

General / background references:Jiang Z et al. Human and rodent MaxiK channel beta-subunit genes: cloning and characterization. Genomics 55:57-67 (1999). PubMed PMID: 9888999
Valverde MA et al. Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit. Science 285:1929-31 (1999). PubMed PMID: 10489376

8 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNMB1 antibody

Western blot analysis of rat smooth muscle lysate: 1. Anti-sloβ1 (KCNMB1) antibody , (1:200). 2. Anti-sloβ1 (KCNMB1) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNMB1 antibody

Immunohistochemistry (IHC) analyzes of MaxiKbeta antibody (Cat.-No.: AP20667PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

KCNMB1 (Center) antibody

Western blot analysis of KCNMB1 Antibody (Center) Cat.-No AP52315PU-N in A549 cell line lysates (35ug/lane). This demonstrates the KCNMB1 antibody detected the KCNMB1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

KCNMB1 control peptide

KCNMB1 ICC/IF, WB
50 µl / €420.00
  Novus Biologicals Inc.

KCNMB1 antibody

Immunohistochemistry: MaxiKbeta Antibody [NBP1-19811] -  MaxiKbeta Antibody [NBP1-19811] - paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

KCNMB1 antibody

Western  Blot:  Maxi Potassium channel beta Antibody [NBP1-33484] – Western blot analysis of Maxi Potassium channel beta on A431 (Lane A) and H1299 (Lane B) lysates using NBP1-33484 at a dilution of 1:1000. Rabbit IgG Hu WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KCNMB1

KCNMB1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

KCNMB1

KCNMB1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

8 Item(s)

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