KCNMB2 antibody

Principal name

KCNMB2 antibody

Alternative names for KCNMB2 antibody

BKbeta2, Hbeta2, Hbeta3, K(VCA)beta-2, Slo-beta-2, Calcium-activated potassium channel subunit beta-2, BK channel subunit beta-2, Calcium-activated potassium channel subfamily M subunit beta-2, Charybdotoxin receptor subunit beta-2, Maxi K channel subunit beta-2

SwissProt ID

Q811Q0 (Rat), Q9CZM9 (Mouse), Q9Y691 (Human)

Gene ID

10242 (KCNMB2), 72413 (Kcnmb2), 294961

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Paraffin Sections (P)

Background of KCNMB2 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release (3). A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological diseases. Findings suggest that the distribution of the beta subunits in the brain can modulate the BK channels to contribute to the pathophysiology of epilepsy and dyskinesia (4). This has major implications on other physiological processes in tissues other than the brain.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNMB2 antibody

  Rabbit polyclonal anti-KCNMB2 antibody  
Western blot analysis of extracts from HepG2 cells, COLO cells and Jurkat cells, using KCNMB2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNMB2 (1-41, 218-235) antibody

  Mouse Monoclonal Anti-BK Beta2 Antibody  
Western blot analysis of BK Beta2 in a human cell line mix using a 1:1000 dilution of the antibody Mouse IgG1 S53-32 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNMB2 antibody

  Rabbit Polyclonal Anti-slobeta2 (KCNMB2)  
Western blot analysis of rat kidney (lanes 1 and 3) and rat heart (lanes 2 and 4) membranes: 1, 2. Anti-sloß2 (KCNMB2) antibody, (1:200). 3, 4. Anti-sloß2(KCNMB2) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNMB2 antibody

  Rabbit Polyclonal Anti-KCNMB2 Antibody  
Host: Rabbit; Target Name: KCNMB2; Sample Tissue: Lung Tumor lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNMB2 antibody

  Rabbit Polyclonal Anti-KCNMB2 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (KCNMB2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNMB2 antibody

Immunoblot against extracts of COS cells transiently transfected with GFP-tagged BKBeta2 or untagged Kv2.1 plasmid and probed with N53/32 (left) or K89/41 (right) TC supe. Mouse IgG1 N53/32 Supernatant Hu, Ms, Rt ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNMB2 antibody

Immunoblot against extracts of COS cells transiently transfected with GFP-tagged BKBeta2 or untagged Kv2.1 plasmid and probed with N53/32 (left) or K89/41 (right) TC supe. Mouse IgG1 N53/32 Purified Hu, Ms, Rt ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNMB2 antibody

Western blot analysis of extracts from Jurkat/COLO/HepG2 cells, using KCNMB2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

KCNMB2 antibody

Western blot analysis of extracts from Jurkat/COLO/HepG2 cells, using KCNMB2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

KCNMB2 - human gene knockout kit via CRISPR

KCNMB2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

KCNMB2 - human gene knockout kit via CRISPR

KCNMB2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNMB2 - human gene knockout kit via CRISPR

KCNMB2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNMB2 - human gene knockout kit via CRISPR

KCNMB2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnmb2 - mouse gene knockout kit via CRISPR

Kcnmb2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Kcnmb2 - mouse gene knockout kit via CRISPR

Kcnmb2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnmb2 - mouse gene knockout kit via CRISPR

Kcnmb2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnmb2 - mouse gene knockout kit via CRISPR

Kcnmb2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KCNMB2 (mGFP-tagged) - Human potassium large conductance calcium-activated channel, subfamily M, beta member 2 (KCNMB2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNMB2 (mGFP-tagged) - Human potassium large conductance calcium-activated channel, subfamily M, beta member 2 (KCNMB2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNMB2 (mGFP-tagged) - Human potassium large conductance calcium-activated channel, subfamily M, beta member 2 (KCNMB2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNMB2 (mGFP-tagged) - Human potassium large conductance calcium-activated channel, subfamily M, beta member 2 (KCNMB2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNMB2 (Myc-DDK tagged) - Human potassium large conductance calcium-activated channel, subfamily M, beta member 2 (KCNMB2), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNMB2 (Myc-DDK tagged) - Human potassium large conductance calcium-activated channel, subfamily M, beta member 2 (KCNMB2), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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