KCNMB2 antibody

Principal name

KCNMB2 antibody

Alternative names for KCNMB2 antibody

BKbeta2, Hbeta2, Hbeta3, K(VCA)beta-2, Slo-beta-2, Calcium-activated potassium channel subunit beta-2, BK channel subunit beta-2, Calcium-activated potassium channel subfamily M subunit beta-2, Charybdotoxin receptor subunit beta-2, Maxi K channel subunit beta-2

SwissProt ID

Q811Q0 (Rat), Q9CZM9 (Mouse), Q9Y691 (Human)

Gene ID

10242 (KCNMB2), 72413 (Kcnmb2), 294961

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Paraffin Sections (P)

Background of KCNMB2 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release (3). A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological diseases. Findings suggest that the distribution of the beta subunits in the brain can modulate the BK channels to contribute to the pathophysiology of epilepsy and dyskinesia (4). This has major implications on other physiological processes in tissues other than the brain.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNMB2 (1-41, 218-235) antibody

  Mouse Monoclonal Anti-BK Beta2 Antibody  
Western blot analysis of BK Beta2 in a human cell line mix using a 1:1000 dilution of the antibody Mouse IgG1 S53-32 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €410.00
  OriGene Technologies, Inc.

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