KCNMB3 antibody

Principal name

KCNMB3 antibody

Alternative names for KCNMB3 antibody

KCNMBL, Maxi K channel subunit beta-3, BK channel subunit beta-3, K(VCA)beta-3, Slo-beta-3, Charybdotoxin receptor subunit beta-3, Calcium-activated potassium channel subunit beta-3, Calcium-activated potassium channel, subfamily M subunit beta-3

SwissProt ID

A7VL23 (Rat), Q9NPA1 (Human)

Gene ID

27094 (KCNMB3), 310303 (Kcnmb3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Can (Canine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of KCNMB3 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release (3). A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological diseases. Findings suggest that the distribution of the beta subunits in the brain can modulate the BK channels to contribute to the pathophysiology of epilepsy and dyskinesia (4). This has major implications on other physiological processes in tissues other than the brain.

General readings

Lee,U.S, et al. (2009) J. Physiol. (Lond.) 587 (PT 7), 1481-1498Zeng,X., et al. (2008) J. Gen. Physiol. 132 (1), 115-129

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNMB3 antibody

Anti-KCNMB3 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Hu
50 µg / €345.00
  OriGene Technologies, Inc.

KCNMB3 antibody

Anti-KCNMB3 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

KCNMB3 (1-49) antibody

Western blot analysis of BKBeta3a in rat brain membrane lysates using a 1:1000 dilution of the antibody Mouse IgG1 S40B-18 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNMB3 antibody

Western blot analysis of mouse brain lysates (lanes 1 and 3) and rat pancreas membranes (lanes 2 and 4): 1-2. Anti-sloβ3 (KCNMB3) (extracellular) antibody , (1:1000). 3-4. Anti-sloβ3 (KCNMB3) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNMB3 antibody

WB Suggested Anti-KCNMB3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Can, Hu, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNMB3 (BKBeta3a) antibody

Adult rat hippocampus immunohistochemistry Mouse IgG1 N40B/18 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNMB3 (BKBeta3a) antibody

Adult rat hippocampus immunohistochemistry Mouse IgG1 N40B/18 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNMB3 antibody

KCNMB3 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

KCNMB3 antibody

Detection limit for recombinant GST tagged KCNMB3 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 5H1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

KCNMB3 antibody

KCNMB3 Mouse IgG1 2C12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

KCNMB3 antibody

KCNMB3 Mouse IgG1 1F1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

KCNMB3 antibody

KCNMB3 Mouse IgG1 3E5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

KCNMB3 antibody

Human HepG2; WB Suggested Anti-KCNMB3 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: HepG2 cell lysate; KCNMB3 antibody - middle region (ARP35444_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

KCNMB3 antibody

Immunohistochemistry-Paraffin: KCNMB3 Antibody [NBP1-83065] - Immunohistochemical staining of human rectum shows strong cytoplasmic positivity in granular pattern in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

KCNMB3 antibody

Immunohistochemistry-Paraffin: KCNMB3 Antibody [NBP1-83066] - Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KCNMB3 (82-207, His-tag)

KCNMB3 Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

KCNMB3 (82-207, His-tag)

KCNMB3 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

KCNMB3

KCNMB3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

KCNMB3

KCNMB3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

KCNMB3 overexpression lysate

KCNMB3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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