KCNMB4 antibody

Principal name

KCNMB4 antibody

Alternative names for KCNMB4 antibody

Maxi K channel subunit beta-4, BK channel subunit beta-4, K(VCA)beta-4, Slo-beta-4, Charybdotoxin receptor subunit beta-4, Calcium-activated potassium channel subunit beta-4, Calcium-activated potassium channel, subfamily M subunit beta-4

SwissProt ID

Q86W47 (Human), Q9ESK8 (Rat), Q9JIN6 (Mouse)

Gene ID

27345 (KCNMB4), 58802 (Kcnmb4), 66016

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Por (Porcine), Rt (Rat), Sh (Sheep)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP)

Background of KCNMB4 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release (3). A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological diseases. Findings suggest that the distribution of the beta subunits in the brain can modulate the BK channels to contribute to the pathophysiology of epilepsy and dyskinesia (4). This has major implications on other physiological processes in tissues other than the brain.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNMB4 antibody

IHC of BK Beta4 in brain tissues using a dilution of the antibody Mouse IgG2a S18A-3 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNMB4 antibody

Western blot analysis of rat brain membranes: 1. Anti-sloβ4 (KCNMB4) antibody , (1:200). 2. Anti- sloβ4 (KCNMB4) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNMB4 antibody

Adult rat hippocampus immunohistochemistry Mouse IgG2a L18A/3 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNMB4 antibody

Adult rat hippocampus immunohistochemistry Mouse IgG2a L18A/3 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNMB4 antibody

Western Blot analysis of KCNMB4 expression in transfected 293T cell line (H00027345-T01) by KCNMB4 MaxPab polyclonal antibody.

Lane 1: KCNMB4 transfected lysate(23.1 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

KCNMB4 antibody

Western Blot analysis of KCNMB4 expression in transfected 293T cell line (H00027345-T02) by KCNMB4 MaxPab polyclonal antibody.

Lane 1: KCNMB4 transfected lysate(23.90 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

KCNMB4 antibody

Detection limit for recombinant GST tagged KCNMB4 is approximately 0.3ng/ml as a capture antibody. Mouse IgG1 1G7 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

KCNMB4 antibody

Human THP-1; WB Suggested Anti-KCNMB4 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: THP-1 cell lysate; KCNMB4 antibody - middle region (ARP35241_P050) in Human THP-1 cells using Western Blot Rabbit Aff - Purified Bov, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

KCNMB4 antibody

Western blot analysis of KCNMB4 expression in THP1 (A) whole cell lysates. Rabbit Aff - Purified Hu, Por, Sh WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

KCNMB4 antibody

Western blot analysis of KCNMB4 expression in THP1 (A) whole cell lysates. Rabbit Aff - Purified Hu, Por, Sh WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

KCNMB4 antibody

Western blot analysis of KCNMB4 expression in THP1 (A) whole cell lysates. Rabbit Aff - Purified Hu, Por, Sh WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

KCNMB4 antibody

KCNMB4 Rabbit Purified Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

KCNMB4 antibody

KCNMB4 Mouse IgG2 S18A-3 Purified Hu, Ms, Rt IP, P, WB
0.1 mg / €450.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KCNMB4

KCNMB4 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

KCNMB4

KCNMB4 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

KCNMB4 Lysate(Denatured)

KCNMB4 Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

KCNMB4 overexpression lysate

KCNMB4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

17 Item(s)

per page
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