KCNN2 antibody

Principal name

KCNN2 antibody

Alternative names for KCNN2 antibody

KCNN2, SK2, Small conductance calcium-activated potassium channel protein 2

SwissProt ID

P58390 (Mouse), P70604 (Rat), Q9H2S1 (Human)

Gene ID

3781 (KCNN2), 54262 (Kcnn2), 140492

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Ze (Zebrafish), Eq (Equine), GP (Guinea Pig), Hst (Hamster), Mky (Monkey), Gorilla, Rb (Rabbit), Ye (Yeast)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of KCNN2 antibody

KCa2.2 is a member of the Ca2+-activated K+ channels family with small conductance that includes KCa2.1 (SK1) and KCa2.3 (SK3). The channel is voltage insensitive and is activated by intracellular Ca2+ in the submicromolar range. It has, though, a similar topology to that of voltage-dependent K+ channels (KV channels), that is six transmembrane domains and intracellular N- and C-termini. The functiol channel of all the KCa2 family members is a multimeric protein composed of four pore-forming subunits.KCa2 channels are extremely sensitive to the levels of intracellular Ca2+ and concentrations as low as 300-700 nM can open the channels very rapidly (5-15 ms). Hence, the KCa2 channels are highly sensitive and fast Ca2+ sensors resembling other known Ca2+-binding proteins. This type of Ca2+-dependent activation is achieved by the constitutive binding of the KCa2 channels to calmodulin, a highly expressed Ca2+-binding protein via a calmodulin-binding domain situated at the cytoplasmic C-terminus.Pharmacologically, the KCa2 channels are the only known targets of the bee venom toxin Apamin, with KCa2.1 being the less sensitive, KCa2.2 the most sensitive and KCa2.3 showing intermediate sensitivity. KCa2.2 is predomintly expressed in the nervous system although expression in endothelial cells, heart and liver has been described. KCa2.2 is known to be involved in the regulation of neurol excitability. They do so mainly via a phenomenon known as after hyperpolarization in which KCa2 channels open in response to increased intracellular Ca2+ concentrations that result from the entry of extracellular Ca2+ through voltage-dependent Ca2+ channels during action potentials. In this way, KCa2 channels effectively form a Ca2+-mediated feedback loop.

General readings

Feranchak,A.P., et al., (2004) Gastroenterology 127 (3), 903-913

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16 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNN2 antibody

WB Suggested Anti-KCNN2 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1:62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ye, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNN2 antibody

WB Suggested Anti-KCNN2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze ICC/IF, WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNN2 antibody

Rhesus macaque spinal cord; . Sample Type :. Rhesus macaque spinal cord. Primary Antibody Dilution :. 1:300. Secondary Antibody :. Donkey anti Rabbit 488. Secondary Antibody Dilution :. 1:500. Color/Signal Descriptions :. Green: KCNN2. Gene Name :. KCNN2. Submitted by :. Timur Mavlyutov, Ph. D., Department of Pharmacology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706; KCNN2 antibody - C-terminal region (ARP35094_T100) in Rhesus macaque spinal cord cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Por, Rt, Ze WB
0.1 mg / €310.00
  AVIVA Systems Biology

KCNN2 antibody

Rhesus macaque spinal cord; . Sample Type :. Rhesus macaque spinal cord. Primary Antibody Dilution :. 1:300. Secondary Antibody :. Donkey anti Rabbit 488. Secondary Antibody Dilution :. 1:500. Color/Signal Descriptions :. Green: KCNN2. Gene Name :. KCNN2. Submitted by :. Timur Mavlyutov, Ph. D., Department of Pharmacology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706; KCNN2 antibody - middle region (ARP35439_P050) in Rhesus macaque spinal cord cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Por, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

KCNN2 antibody

AP10032PU-N KCNN2 antibody staining of Paraffin Embedded Human Thyroid Gland at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

KCNN2 antibody

Anti-KCNN2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Eq, Gorilla, GP, Hst, Hu, Mky
50 µg / €345.00
  OriGene Technologies, Inc.

KCNN2 antibody

Western blot analysis of rat brain membranes: 1. Anti-KCa2.2 (SK2) antibody, (1:200). 2. Anti-KCa2.2 (SK2) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Western Blot/IP/ChiP Kits

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNN2 Western Blot Kit

KCNN2 Western Blot Kit Hu
25 Western Blots / kit / €640.00
  AVIVA Systems Biology

KCNN2 Western Blot kit

KCNN2 Western Blot kit
1 kit / €640.00
  AVIVA Systems Biology

CRISPR

Catalog No. Species Donor Vector  

Kcnn2 - mouse gene knockout kit via CRISPR

Kcnn2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Kcnn2 - mouse gene knockout kit via CRISPR

Kcnn2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

KCNN2 overexpression lysate

KCNN2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

KCNN2 overexpression lysate

KCNN2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KCNN2 (mGFP-tagged) - Human potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (KCNN2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNN2 (mGFP-tagged) - Human potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (KCNN2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Kcnn2 (GFP-tagged ORF) - Rat potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (Kcnn2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnn2 (GFP-tagged ORF) - Rat potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (Kcnn2), 200 uL, >10^7 TU/mL  
200 µl / €1,220.00
  OriGene Technologies, Inc.

Lenti ORF particles, Kcnn2 (Myc-DDK-tagged ORF) - Rat potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (Kcnn2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnn2 (Myc-DDK-tagged ORF) - Rat potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (Kcnn2), 200 uL, >10^7 TU/mL  
200 µl / €1,097.00
  OriGene Technologies, Inc.

16 Item(s)

per page
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