KCNN3 antibody

Principal name

KCNN3 antibody

Alternative names for KCNN3 antibody

KCNN3, K3, SKCa3, SK3, Small conductance calcium-activated potassium channel protein 3

SwissProt ID

P58391 (Mouse), P58392 (Pig), P70605 (Rat), Q7KVW5 (Drome), Q9UGI6 (Human)

Gene ID

3782 (KCNN3), 54263 (Kcnn3)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E), Frozen Sections (C), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of KCNN3 antibody

KCa2.3 is a member of the Ca2+-activated K+ channels family with small conductance that includes KCa2.1 (SK1) and KCa2.2 (SK2). The channel is voltage insensitive and is activated by intracellular Ca2+ in the submicromolar range. It has, though, a similar topology to that of voltage-dependent K+ channels (Kv channels), that is six transmembrane domains and intracellular N- and C-termini. The functiol channel of all the KCa2 family members is a multimeric protein composed of four pore-forming subunits. KCa2 channels are extremely sensitive to the levels of intracellular Ca2+ and concentrations as low as 300-700 nM can open the channels very rapidly (5-15 ms). Hence, the KCa2 channels are highly sensitive and fast Ca2+ sensors resembling other known Ca2+-binding proteins. This type of Ca2+-dependent activation is achieved by the constitutive binding of the KCa2 channels to calmodulin, a highly expressed Ca2+-binding protein via a calmodulin-binding domain situated at the cytoplasmic C-termini. Pharmacologically, the KCa2 channels are the only known targets of the bee venom toxin Apamin, with KCa2.1 being the less sensitive, KCa2.2 the most sensitive and KCa2.3 showing intermediate sensitivity. KCa2.3 is predomintly expressed in the nervous system although expression in endothelial cells, heart and liver have been described. KCa2.3 is known to be involved in the regulation of neurol excitability. They do so mainly via a phenomenon known as afterhyperpolarization in which KCa2 channels open in response to increased intracellular Ca2+ concentrations that result from the entry of extracellular Ca2+ through voltage-dependent Ca2+ channels during action potentials. In this way, KCa2 channels effectively form a Ca2+-mediated feedback loop. KCa2.3 is involved in the control of firing rate and subsequent dopamine secretion from midbrain dopaminergic neurons. Since malfunction of these neurons is involved in several pathological disorders such as Parkinson’s disease and schizophrenia, modulators of the KCa2.3 channels have been proposed to be of therapeutic value in these diseases.

General readings

Kolski-Andreaco,A., et al., (2004) J. Biol. Chem. 279 (8), 6893-6904

15 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNN3 antibody

Western blot analysis of rat brain membranes: 1. Anti-KCa2.3 (SK3) (N-term) antibody, (1:200). 2. Anti-KCa2.3 (SK3) (N-term) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNN3 antibody

Western blot analysis of rat brain membranes: 1. Anti- KCa2.3 (SK3) (C-term) antibody, (1:200). 2. Anti-KCa2.3 (SK3) (C-term) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNN3 antibody

KCNN3 antibody - C-terminal region  validated by WB using Mouse kidney , Whole brain lysate at 2 ug/ml. Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNN3 antibody

KCNN3 polyclonal antibody (A01), Lot # 050921JC01 Western Blot analysis of KCNN3 expression in Y-79 ( Cat # L042V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

KCNN3 antibody

Rhesus macaque spinal cord; . Sample Type :. Rhesus macaque spinal cord. Primary Antibody Dilution :. 1:300. Secondary Antibody :. Donkey anti Rabbit 488. Secondary Antibody Dilution :. 1:500. Color/Signal Descriptions :. Green: KCNN3. Gene Name :. KCNN3. Submitted by :. Timur Mavlyutov, Ph. D., Department of Pharmacology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706; KCNN3 antibody - C-terminal region (ARP35097_P050) in Rhesus macaque spinal cord cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

KCNN3 antibody

KCNN3 Rabbit Hu, Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KCNN3

KCNN3 Human
2 µg / €300.00
  Abnova Taiwan Corp.

KCNN3

KCNN3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

KCNN3

KCNN3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

KCNN3

KCNN3 Human Purified
10 µg / €380.00
  Abnova Taiwan Corp.

KCNN3

KCNN3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

KCNN3

KCNN3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

KCNN3

KCNN3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

KCNN3

KCNN3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

KCNN3 overexpression lysate

KCNN3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

15 Item(s)

per page
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