KCNQ1 antibody

Principal name

KCNQ1 antibody

Alternative names for KCNQ1 antibody

KCNA8, KCNA9, KVLQT1, KQT-like 1, Potassium voltage-gated channel subfamily KQT member 1, Voltage-gated potassium channel subunit Kv7.1, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1

SwissProt ID

O97531 (Felca), P51787 (Human), P70057 (Xenla), P97414 (Mouse), Q9MYS6 (Rabit), Q9TTJ7 (Pig), Q9Z0N7 (Rat)

Gene ID

3784 (KCNQ1)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Eq (Equine), GP (Guinea Pig), Ze (Zebrafish)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of KCNQ1 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics.
The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gate channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Specifically, Kv7.1 (KvLQT1) is a potassium channel protein coded for by the gene KCNQ1. Kv7.1 is present in the cell membranes of cardiac muscle tissue and in inner ear neurons (3) among other tissues. In the cardiac cells, Kv7.1 mediates the IKs (or slow delayed rectifying K+) current that contributes to the repolarization of the cell, terminating the cardiac action potential and thereby the heart's contraction (4, 5).

General readings

1. Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, Yamagata K, Hinokio Y, Wang HY, Tanahashi T, Nakamura N, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Takeda J, Maeda E, Shin HD, Cho YM, Park KS, Lee HK, Ng MC, Ma RC, So WY, Chan JC, Lyssenko V, Tuomi T, Nilsson P, Groop L, Kamatani N, Sekine A, Nakamura Y, Yamamoto K, Yoshida T, Tokunaga K, Itakura M, Makino H, Nanjo K, Kadowaki T, Kasuga M.
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.
Nat Genet. 2008 Aug 17.
PMID: 18711367

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNQ1 antibody

Western blot analysis using KCNQ1 mAb against human KCNQ1 (AA: 229-347) recombinant protein. (Expected MW is 74.7 kDa) Mouse IgG2b 5E12 Ascites Hu E, F, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

KCNQ1 (C-term) antibody

TA305704 (1ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNQ1 antibody

Western blot analysis of KCNQ1 in T-Cho cells using a 1:1000 dilution of the antibody Mouse IgG1 S37A-10 Purified Hu, Ms, Rt C, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNQ1 antibody

Western blot analysis of extracts of l various cell lines, using KCNQ1 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNQ1 antibody

Western blot analysis of rat heart membranes: 1. Anti-Kv7.1 (KCNQ1) antibody, (1:200). 2. Anti-Kv7.1 (KCNQ1) antibody, preincubated with the control peptide antigen Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNQ1 antibody

WB Suggested Anti-KCNQ1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNQ1 antibody

WB Suggested Anti-KCNQ1 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1:62500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNQ1 antibody

Transfected cell immunofluorescence: COS-1 cells expressing KCNQ1. Red = N37A/10, Blue = Hoechst nuclear stain. Mouse IgG1 N37A/10 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNQ1 antibody

Transfected cell immunofluorescence: COS-1 cells expressing KCNQ1. Red = N37A/10, Blue = Hoechst nuclear stain. Mouse IgG1 N37A/10 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNQ1 (N-term) antibody

Western blot analysis of KCNQ1 Antibody (N-term) Cat.-No AP52316PU-N in MDA-MB435 cell line lysates (35ug/lane). This demonstrates the KCNQ1 antibody detected the KCNQ1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

KCNQ1 antibody

KCNQ1 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

KCNQ1 (N-term) antibody

Human Kidney; Kidney; KCNQ1 antibody - N-terminal region (ARP34924_P050) in Human Kidney cells using Immunohistochemistry Rabbit Aff - Purified Bov, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

KCNQ1 antibody

Hamster; . Lanes: 100 ug CHO cell lysate. Primary Antibody Dilution: 1:1000. Secondary Antibody: Goat anti-rabbit HRP. Secondary Antibody Dilution: 1:25000. Gene Name: KCNQ1. Submitted by: Anonymous.; KCNQ1 antibody - N-terminal region (ARP35529_T100) in Hamster cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rb, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

KCNQ1 antibody

Western blot analysis of Kv7.1 expression in MCF7 (A); A431 (B); mouse brain (C); rat brain (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

KCNQ1 antibody

Western blot analysis of Kv7.1 expression in MCF7 (A); A431 (B); mouse brain (C); rat brain (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

KCNQ1 antibody

Western blot analysis of Kv7.1 expression in MCF7 (A); A431 (B); mouse brain (C); rat brain (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

KCNQ1 (2-101) antibody

Kv7.1 staining of COS-1 cells expressing KCNQ1 (red) and nuclei counter- stained with Hoechst (blue). Mouse IgG1 N37A/10 Aff - Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €440.00
  Neuromics Antibodies

KCNQ1 antibody

Western Blot: KCNQ1 Antibody [NBP1-30119] - KCNQ1 Antibody (1 ug/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

KCNQ1 antibody

KCNQ1 Rabbit Purified Hu, Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

KCNQ1 overexpression lysate

KCNQ1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

20 Item(s)

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