KCNQ2 antibody

Principal name

KCNQ2 antibody

Alternative names for KCNQ2 antibody

Potassium voltage-gated channel subfamily KQT member 2, Voltage-gated potassium channel subunit Kv7.2, KvLQT2, KQT-like 2, Neuroblastoma-specific potassium channel subunit alpha KvLQT2

SwissProt ID

O43526 (Human), O88943 (Rat), Q9Z351 (Mouse)

Gene ID

3785 (KCNQ2), 170848 (Kcnq2)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of KCNQ2 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics.
The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Specifically, Kv7.2 (KvLQT2) is a potassium channel protein coded for by the gene KCNQ2. It is associated with benign familial neonatal convulsions (3).

General readings

1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd
Ed., Sinauer Associated Inc.: Sunderland, MA USA.
2. www.iochannels.org
3. Wuttke T.V., et al. (2008) J Physiol. 586(2): 545-555.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNQ2 antibody

  Mouse monoclonal KCNQ2 Antibody  
IHC analysis of KCNQ2 in human hippocampal tissues using the antibody Mouse IgG1 S26A-23 Purified Hu, Ms, Rt C, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNQ2 antibody

  Rabbit polyclonal Anti-KV7.2 (KCNQ2)  
Western blot analysis of Kv7.2 transfected HEK-293 cells: 1. Anti-Kv7.2 (KCNQ2) antibody , (1:200). 2. Anti-Kv7.2 (KCNQ2) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNQ2 antibody

  Rabbit Polyclonal Anti-KCNQ2 Antibody  
WB Suggested Anti-KCNQ2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:12500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNQ2 antibody

  Rabbit Polyclonal Anti-KCNQ2 Antibody  
WB Suggested Anti-KCNQ2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: NCI-H226 cell lysateThere is BioGPS gene expression data showing that KCNQ2 is expressed in NCIH226 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNQ2 antibody

  Rabbit Polyclonal Anti-KCNQ2 Antibody  
WB Suggested Anti-KCNQ2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNQ2 antibody

  Rabbit Polyclonal Anti-KCNQ2 Antibody  
WB Suggested Anti-KCNQ2 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1:62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNQ2 antibody

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS-1 cells transiently transfected with KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 or Kv2.1 plasmids and probed with pure N26A/23. Mouse IgG1 N26A/23 Supernatant Hu, Ms, Rt WB
5 ml / €460.00
  Antibodies Incorporated

NeuroMab

KCNQ2 antibody

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS-1 cells transiently transfected with KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 or Kv2.1 plasmids and probed with pure N26A/23. Mouse IgG1 N26A/23 Purified Hu, Ms, Rt WB
0.1 ml / €540.00
  Antibodies Incorporated

NeuroMab

KCNQ2 antibody

KCNQ2 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

KCNQ2 pThr246 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Kv7.3/KCNQ3 (Phospho-Thr246) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
50 µg / €230.00
  Assay Biotech

KCNQ2 pThr246 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Kv7.3/KCNQ3 (Phospho-Thr246) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €330.00
  Assay Biotech

KCNQ2 (1-59) antibody

Kv7.2 (dilution 1:100) staining of rat skin sliced into 40μm cryo-sections (red) and counter stained with NF-H (green) doi:10.3389/fnmol.2012.00063. Mouse IgG1 Aff - Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €440.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

KCNQ2 - human gene knockout kit via CRISPR

KCNQ2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

KCNQ2 - human gene knockout kit via CRISPR

KCNQ2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNQ2 - human gene knockout kit via CRISPR

KCNQ2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNQ2 - human gene knockout kit via CRISPR

KCNQ2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

KCNQ2 overexpression lysate

KCNQ2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KCNQ2 (mGFP-tagged)-Human potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNQ2 (mGFP-tagged)-Human potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,810.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNQ2 (mGFP-tagged)-Human potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNQ2 (mGFP-tagged)-Human potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,800.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNQ2 (mGFP-tagged)-Human potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNQ2 (mGFP-tagged)-Human potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €1,800.00
  OriGene Technologies, Inc.

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